Abstract
A case-control study was carried out between May 1988 and May 1989 to assess the effectiveness of three doses of trivalent oral poliomyelitis vaccine (TOPV3) in children aged 6-35 months in Madras city. All the cases were patients with acute paralytic poliomyelitis who were residing in Madras city and were hospitalized in the Institute of Child Health; they represented 95% of such cases in the city. The diagnosis was based on clinical grounds and confirmed by stool culture which was positive in 60%. Age- and sex-matched controls, all residing in the city of Madras, were recruited concurrently from the Institute's outpatient department. There were 78 cases and 315 controls. Vaccine efficacy observed for TOPV3 was 81% (95% CI, 58-91%) for the 6-35-month age group and 86% (95% CI, 67-94%) for the 6-23-month age group. Vaccine efficacy, after controlling for age using the Mantel-Haenszel method, was 83% (95% CI, 67-91%). An unimmunized child was at 5 times greater risk of developing acute paralytic poliomyelitis than a fully immunized child.
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- Deivanayagam N., Nedunchelian K. Acute poliomyelitis in children: comparison of epidemiological and clinical features among immunized, partially immunized and unimmunized. Indian Pediatr. 1991 Jun;28(6):609–613. [PubMed] [Google Scholar]
- John T. J. Antibody response of infants in tropics to five doses of oral polio vaccine. Br Med J. 1976 Apr 3;1(6013):812–812. doi: 10.1136/bmj.1.6013.812. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim-Farley R. J., Dave K. H., Sokhey J., Mandke V. B. Poliomyelitis surveillance and vaccine efficacy in Bombay, 1982-87. Bull World Health Organ. 1989;67(6):663–667. [PMC free article] [PubMed] [Google Scholar]
- Kim-Farley R. J., Rutherford G., Lichfield P., Hsu S. T., Orenstein W. A., Schonberger L. B., Bart K. J., Lui K. J., Lin C. C. Outbreak of paralytic poliomyelitis, Taiwan. Lancet. 1984 Dec 8;2(8415):1322–1324. doi: 10.1016/s0140-6736(84)90831-6. [DOI] [PubMed] [Google Scholar]
- Lasch E. E., Abed Y., Abdulla K., El Tibbi A. G., Marcus O., El Massri M., Handscher R., Gerichter C. B., Melnick J. L. Successful results of a program combining live and inactivated poliovirus vaccines to control poliomyelitis in Gaza. Rev Infect Dis. 1984 May-Jun;6 (Suppl 2):S467–S470. doi: 10.1093/clinids/6.supplement_2.s467. [DOI] [PubMed] [Google Scholar]
- Orenstein W. A., Bernier R. H., Hinman A. R. Assessing vaccine efficacy in the field. Further observations. Epidemiol Rev. 1988;10:212–241. doi: 10.1093/oxfordjournals.epirev.a036023. [DOI] [PubMed] [Google Scholar]
- Santhanakrishnan B. R., Deivanayagam N., Appachi E., Parthasarathy A. Poliomyelitis in children. Indian J Pediatr. 1987 Sep-Oct;54(5):755–758. doi: 10.1007/BF02751297. [DOI] [PubMed] [Google Scholar]
- Sen S., Sharma D., Singh S., Malik P., Khare S., Kumari S. Poliomyelitis in vaccinated children. Indian Pediatr. 1989 May;26(5):423–429. [PubMed] [Google Scholar]
- Singh J., Kumar K., Bora D., Chawla U., Bilochi N. C., Sharma R. S., Kapur M. L., Kumar S., Aggarwal B. K., Dhaon J. K. Epidemiological evaluation of oral polio vaccine efficacy in Delhi. Indian J Pediatr. 1992 May-Jun;59(3):321–323. doi: 10.1007/BF02821797. [DOI] [PubMed] [Google Scholar]
- Sokhey J., Kim-Farley R. J., Bhargava I. Case definitions in the surveillance of vaccine preventable diseases. Indian Pediatr. 1988 Jul;25(7):599–604. [PubMed] [Google Scholar]
- Sutter R. W., Patriarca P. A., Brogan S., Malankar P. G., Pallansch M. A., Kew O. M., Bass A. G., Cochi S. L., Alexander J. P., Hall D. B. Outbreak of paralytic poliomyelitis in Oman: evidence for widespread transmission among fully vaccinated children. Lancet. 1991 Sep 21;338(8769):715–720. doi: 10.1016/0140-6736(91)91442-w. [DOI] [PubMed] [Google Scholar]