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. 1995 Dec;59(4):646–672. doi: 10.1128/mr.59.4.646-672.1995

Production and function of cytokines in natural and acquired immunity to Candida albicans infection.

R B Ashman 1, J M Papadimitriou 1
PMCID: PMC239393  PMID: 8531890

Abstract

Host resistance against infections caused by the yeast Candida albicans is mediated predominantly by polymorphonuclear leukocytes and macrophages. Antigens of Candida stimulate lymphocyte proliferation and cytokine synthesis, and in both humans and mice, these cytokines enhance the candidacidal functions of the phagocytic cells. In systemic candidiasis in mice, cytokine production has been found to be a function of the CD4+ T helper (Th) cells. The Th1 subset of these cells, characterized by the production of gamma interferon and interleukin-2, is associated with macrophage activation and enhanced resistance against reinfection, whereas the Th2 subset, which produces interleukins-4, -6, and -10, is linked to the development of chronic disease. However, other models have generated divergent data. Mucosal infection generally elicits Th1-type cytokine responses and protection from systemic challenge, and identification of cytokine mRNA present in infected tissues of mice that develop mild or severe lesions does not show pure Th1- or Th2-type responses. Furthermore, antigens of C. albicans, mannan in particular, can induce suppressor cells that modulate both specific and nonspecific cellular and humoral immune responses, and there is an emerging body of evidence that molecular mimicry may affect the efficiency of anti-Candida responses within defined genetic contexts.

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Selected References

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  1. Akagawa G., Abe S., Yamaguchi H. Mortality of Candida albicans-infected mice is facilitated by superinfection of Escherichia coli or administration of its lipopolysaccharide. J Infect Dis. 1995 Jun;171(6):1539–1544. doi: 10.1093/infdis/171.6.1539. [DOI] [PubMed] [Google Scholar]
  2. Alaei S., Larcher C., Ebenbichler C., Prodinger W. M., Janatova J., Dierich M. P. Isolation and biochemical characterization of the iC3b receptor of Candida albicans. Infect Immun. 1993 Apr;61(4):1395–1399. doi: 10.1128/iai.61.4.1395-1399.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Allendoerfer R., Magee D. M., Smith J. G., Bonewald L., Graybill J. R. Induction of tumor necrosis factor-alpha in murine Candida albicans infection. J Infect Dis. 1993 May;167(5):1168–1172. doi: 10.1093/infdis/167.5.1168. [DOI] [PubMed] [Google Scholar]
  4. Arai K. I., Lee F., Miyajima A., Miyatake S., Arai N., Yokota T. Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem. 1990;59:783–836. doi: 10.1146/annurev.bi.59.070190.004031. [DOI] [PubMed] [Google Scholar]
  5. Arancia G., Molinari A., Crateri P., Stringaro A., Ramoni C., Dupuis M. L., Gomez M. J., Torosantucci A., Cassone A. Noninhibitory binding of human interleukin-2-activated natural killer cells to the germ tube forms of Candida albicans. Infect Immun. 1995 Jan;63(1):280–288. doi: 10.1128/iai.63.1.280-288.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ashman R. B., Bolitho E. M., Fulurija A. Cytokine mRNA in brain tissue from mice that show strain-dependent differences in the severity of lesions induced by systemic infection with Candida albicans yeast. J Infect Dis. 1995 Sep;172(3):823–830. doi: 10.1093/infdis/172.3.823. [DOI] [PubMed] [Google Scholar]
  7. Ashman R. B., Bolitho E. M., Papadimitriou J. M. Patterns of resistance to Candida albicans in inbred mouse strains. Immunol Cell Biol. 1993 Jun;71(Pt 3):221–225. doi: 10.1038/icb.1993.25. [DOI] [PubMed] [Google Scholar]
  8. Ashman R. B., Bolitho E. M. Strain differences in the severity of lesions in murine systemic candidiasis correlate with the production of functional gamma interferon by Candida-activated lymphocytes in vitro. Lymphokine Cytokine Res. 1993 Dec;12(6):471–476. [PubMed] [Google Scholar]
  9. Ashman R. B. Enhancement of MHC class II antigen expression by exposure to Candida albicans. Immunol Lett. 1991 Oct;30(2):255–260. doi: 10.1016/0165-2478(91)90034-8. [DOI] [PubMed] [Google Scholar]
  10. Ashman R. B., Kay P. H., Lynch D. M., Ott K. Association of a complement allotype (C3F) with acute inflammatory responses to Candida albicans infection. Med J Aust. 1994 Jun 6;160(11):732–733. [PubMed] [Google Scholar]
  11. Ashman R. B., Kay P. H., Lynch D. M., Papadimitriou J. M. Murine candidiasis: sex differences in the severity of tissue lesions are not associated with levels of serum C3 and C5. Immunol Cell Biol. 1991 Feb;69(Pt 1):7–10. doi: 10.1038/icb.1991.2. [DOI] [PubMed] [Google Scholar]
  12. Ashman R. B. Mouse candidiasis. II. Host responses are T-cell dependent and regulated by genes in the major histocompatibility complex. Immunogenetics. 1987;25(3):200–203. doi: 10.1007/BF00344035. [DOI] [PubMed] [Google Scholar]
  13. Ashman R. B. Murine candidiasis. III. Host inflammatory responses are regulated in part by class I MHC genes. J Immunogenet. 1987 Dec;14(6):317–321. doi: 10.1111/j.1744-313x.1987.tb00397.x. [DOI] [PubMed] [Google Scholar]
  14. Ashman R. B. Murine candidiasis: cell-mediated immune responses correlate directly with susceptibility and resistance to infection. Immunol Cell Biol. 1990 Feb;68(Pt 1):15–20. doi: 10.1038/icb.1990.2. [DOI] [PubMed] [Google Scholar]
  15. Ashman R. B. Murine candidiasis: susceptibility is associated with the induction of T cell-mediated, strain-specific autoreactivity. Immunol Cell Biol. 1990 Jun;68(Pt 3):179–185. doi: 10.1038/icb.1990.25. [DOI] [PubMed] [Google Scholar]
  16. Ashman R. B., Ott A. K. Autoimmunity as a factor in recurrent vaginal candidosis and the minor vestibular gland syndrome. J Reprod Med. 1989 Apr;34(4):264–266. [PubMed] [Google Scholar]
  17. Ashman R. B., Papadimitriou J. M. Chronic osteomyelitis as a consequence of systemic Candida albicans infection. Immunol Cell Biol. 1991 Dec;69(Pt 6):427–429. doi: 10.1038/icb.1991.60. [DOI] [PubMed] [Google Scholar]
  18. Ashman R. B., Papadimitriou J. M. Genetic regulation of pathogenesis and host responses in fungal infection. Immunol Ser. 1989;47:347–371. [PubMed] [Google Scholar]
  19. Ashman R. B., Papadimitriou J. M. Genetic resistance to Candida albicans infection is conferred by cells derived from the bone marrow. J Infect Dis. 1992 Oct;166(4):947–948. doi: 10.1093/infdis/166.4.947. [DOI] [PubMed] [Google Scholar]
  20. Ashman R. B., Papadimitriou J. M. Murine candidiasis. Pathogenesis and host responses in genetically distinct inbred mice. Immunol Cell Biol. 1987 Apr;65(Pt 2):163–171. doi: 10.1038/icb.1987.18. [DOI] [PubMed] [Google Scholar]
  21. Ashman R. B., Papadimitriou J. M. Murine candidiasis: strain dependence of host responses after immunization. Immunol Cell Biol. 1988 Jan;66(Pt 3):231–237. doi: 10.1038/icb.1988.29. [DOI] [PubMed] [Google Scholar]
  22. Ashman R. B., Papadimitriou J. M., Ott A. K., Warmington J. R. Antigens and immune responses in Candida albicans infection. Immunol Cell Biol. 1990 Feb;68(Pt 1):1–13. doi: 10.1038/icb.1990.1. [DOI] [PubMed] [Google Scholar]
  23. Ashman R. B., Papadimitriou J. M. Strain dependence of antibody-mediated protection in murine systemic candidiasis. J Infect Dis. 1993 Aug;168(2):511–513. doi: 10.1093/infdis/168.2.511-a. [DOI] [PubMed] [Google Scholar]
  24. Ashman R. B., Papadimitriou J. M. Susceptibility of beige mutant mice to candidiasis may be linked to a defect in granulocyte production by bone marrow stem cells. Infect Immun. 1991 Jun;59(6):2140–2146. doi: 10.1128/iai.59.6.2140-2146.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Ashman R. B., Papadimitriou J. M. What's new in the mechanisms of host resistance to Candida albicans infection? Pathol Res Pract. 1990 Aug;186(4):527–534. doi: 10.1016/S0344-0338(11)80477-2. [DOI] [PubMed] [Google Scholar]
  26. Ashman R. B. The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2k strains of mice. Immunogenetics. 1985;22(6):585–591. doi: 10.1007/BF00430306. [DOI] [PubMed] [Google Scholar]
  27. Attia W. Y., Badamchian M., Goldstein A. L., Spangelo B. L. Thymosin stimulates interleukin-6 production from rat spleen cells in vitro. Immunopharmacology. 1993 Sep-Oct;26(2):171–179. doi: 10.1016/0162-3109(93)90009-f. [DOI] [PubMed] [Google Scholar]
  28. Ausiello C. M., Spagnoli G. C., Antonelli G., Malavasi F., Dianzani F., Casciani C. U., Cassone A. Generation and characterization of cytotoxic activity against tumor cell lines in human peripheral blood mononuclear cells stimulated "in vitro" by a glucomannan-protein preparation of Candida albicans. J Biol Regul Homeost Agents. 1987 Apr-Jun;1(2):59–68. [PubMed] [Google Scholar]
  29. Ausiello C. M., Spagnoli G. C., Boccanera M., Casalinuovo I., Malavasi F., Casciani C. U., Cassone A. Proliferation of human peripheral blood mononuclear cells induced by Candida albicans and its cell wall fractions. J Med Microbiol. 1986 Nov;22(3):195–202. doi: 10.1099/00222615-22-3-195. [DOI] [PubMed] [Google Scholar]
  30. Ausiello C. M., Urbani F., Gessani S., Spagnoli G. C., Gomez M. J., Cassone A. Cytokine gene expression in human peripheral blood mononuclear cells stimulated by mannoprotein constituents from Candida albicans. Infect Immun. 1993 Oct;61(10):4105–4111. doi: 10.1128/iai.61.10.4105-4111.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Baccarini M., Bistoni F., Lohmann-Matthes M. L. In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells. J Immunol. 1985 Apr;134(4):2658–2665. [PubMed] [Google Scholar]
  32. Baghian A., Lee K. W. Elimination of Candida albicans from kidneys of mice during short-term systemic infections. Kidney Int. 1991 Sep;40(3):400–405. doi: 10.1038/ki.1991.225. [DOI] [PubMed] [Google Scholar]
  33. Baghian A., Lee K. W. Systemic candidosis in beige mice. J Med Vet Mycol. 1989;27(1):51–55. doi: 10.1080/02681218980000071. [DOI] [PubMed] [Google Scholar]
  34. Balish E., Filutowicz H., Oberley T. D. Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice. Infect Immun. 1990 Jan;58(1):107–113. doi: 10.1128/iai.58.1.107-113.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Balish E., Jensen J., Warner T., Brekke J., Leonard B. Mucosal and disseminated candidiasis in gnotobiotic SCID mice. J Med Vet Mycol. 1993;31(2):143–154. doi: 10.1080/02681219380000161. [DOI] [PubMed] [Google Scholar]
  36. Baschieri S., Lees R. K., Lussow A. R., MacDonald H. R. Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. Eur J Immunol. 1993 Oct;23(10):2661–2666. doi: 10.1002/eji.1830231041. [DOI] [PubMed] [Google Scholar]
  37. Beno D. W., Mathews H. L. Growth inhibition of Candida albicans by interleukin-2-activated splenocytes. Infect Immun. 1992 Mar;60(3):853–863. doi: 10.1128/iai.60.3.853-863.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Beno D. W., Mathews H. L. Growth inhibition of Candida albicans by interleukin-2-induced lymph node cells. Cell Immunol. 1990 Jun;128(1):89–100. doi: 10.1016/0008-8749(90)90009-g. [DOI] [PubMed] [Google Scholar]
  39. Beno D. W., Stöver A. G., Mathews H. L. Growth inhibition of Candida albicans hyphae by CD8+ lymphocytes. J Immunol. 1995 May 15;154(10):5273–5281. [PubMed] [Google Scholar]
  40. Bistoni F., Baccarini M., Blasi E., Riccardi C., Marconi P., Garaci E. Modulation of polymorphonucleate-mediated cytotoxicity against Candida albicans by thymosin alpha 1. Thymus. 1985;7(2):69–84. [PubMed] [Google Scholar]
  41. Bistoni F., Cenci E., Mencacci A., Schiaffella E., Mosci P., Puccetti P., Romani L. Mucosal and systemic T helper cell function after intragastric colonization of adult mice with Candida albicans. J Infect Dis. 1993 Dec;168(6):1449–1457. doi: 10.1093/infdis/168.6.1449. [DOI] [PubMed] [Google Scholar]
  42. Bistoni F., Marconi P., Frati L., Bonmassar E., Garaci E. Increase of mouse resistance to Candida albicans infection by thymosin alpha 1. Infect Immun. 1982 May;36(2):609–614. doi: 10.1128/iai.36.2.609-614.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Bistoni F., Vecchiarelli A., Cenci E., Puccetti P., Marconi P., Cassone A. Evidence for macrophage-mediated protection against lethal Candida albicans infection. Infect Immun. 1986 Feb;51(2):668–674. doi: 10.1128/iai.51.2.668-674.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Bistoni F., Verducci G., Perito S., Vecchiarelli A., Puccetti P., Marconi P., Cassone A. Immunomodulation by a low-virulence, agerminative variant of Candida albicans. Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection. J Med Vet Mycol. 1988;26(5):285–299. doi: 10.1080/02681218880000401. [DOI] [PubMed] [Google Scholar]
  45. Blanchard D. K., Michelini-Norris M. B., Djeu J. Y. Production of granulocyte-macrophage colony-stimulating factor by large granular lymphocytes stimulated with Candida albicans: role in activation of human neutrophil function. Blood. 1991 May 15;77(10):2259–2265. [PubMed] [Google Scholar]
  46. Blanden R. V., Ashman R. B., O'Neill H. C., Woodhams C. E., Kees U. R., Andrew M. E. Incomplete tolerance to MHC antigens in irradiation chimeras: implications for MHC restriction and self tolerance. Immunol Rev. 1981;58:25–36. doi: 10.1111/j.1600-065x.1981.tb00348.x. [DOI] [PubMed] [Google Scholar]
  47. Blanden R. V., Hodgkin P. D., Hill A., Sinickas V. G., Müllbacher A. Quantitative considerations of T-cell activation and self tolerance. Immunol Rev. 1987 Aug;98:75–93. doi: 10.1111/j.1600-065x.1987.tb00520.x. [DOI] [PubMed] [Google Scholar]
  48. Blasi E., Pitzurra L., Bartoli A., Puliti M., Bistoni F. Tumor necrosis factor as an autocrine and paracrine signal controlling the macrophage secretory response to Candida albicans. Infect Immun. 1994 Apr;62(4):1199–1206. doi: 10.1128/iai.62.4.1199-1206.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Blasi E., Pitzurra L., Chimienti A. R., Mazzolla R., Puliti M., Barluzzi R., Bistoni F. Differential susceptibility of yeast and hyphal forms of Candida albicans to proteolytic activity of macrophages. Infect Immun. 1995 Apr;63(4):1253–1257. doi: 10.1128/iai.63.4.1253-1257.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Blasi E., Pitzurra L., Puliti M., Chimienti A. R., Mazzolla R., Barluzzi R., Bistoni F. Differential susceptibility of yeast and hyphal forms of Candida albicans to macrophage-derived nitrogen-containing compounds. Infect Immun. 1995 May;63(5):1806–1809. doi: 10.1128/iai.63.5.1806-1809.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Blasi E., Pitzurra L., Puliti M., Lanfrancone L., Bistoni F. Early differential molecular response of a macrophage cell line to yeast and hyphal forms of Candida albicans. Infect Immun. 1992 Mar;60(3):832–837. doi: 10.1128/iai.60.3.832-837.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Blasi E., Puliti M., Pitzurra L., Barluzzi R., Mazzolla R., Adami C., Cox G. W., Bistoni F. Comparative studies on functional and secretory properties of macrophage cell lines derived from different anatomical sites. FEMS Immunol Med Microbiol. 1994 Sep;9(3):207–215. doi: 10.1111/j.1574-695X.1994.tb00495.x. [DOI] [PubMed] [Google Scholar]
  53. Blasi E., Puliti M., Pitzurra L., Bartoli A., Bistoni F. Heterogeneous secretory response of phagocytes from different anatomical districts to the dimorphic fungus Candida albicans. Cell Immunol. 1994 Jan;153(1):239–247. doi: 10.1006/cimm.1994.1021. [DOI] [PubMed] [Google Scholar]
  54. Bodey G. P. Fungal infections complicating acute leukemia. J Chronic Dis. 1966 Jun;19(6):667–687. doi: 10.1016/0021-9681(66)90066-x. [DOI] [PubMed] [Google Scholar]
  55. Brummer E., McEwen J. G., Stevens D. A. Fungicidal activity of murine inflammatory polymorphonuclear neutrophils: comparison with murine peripheral blood PMN. Clin Exp Immunol. 1986 Dec;66(3):681–690. [PMC free article] [PubMed] [Google Scholar]
  56. Brummer E., Morrison C. J., Stevens D. A. Recombinant and natural gamma-interferon activation of macrophages in vitro: different dose requirements for induction of killing activity against phagocytizable and nonphagocytizable fungi. Infect Immun. 1985 Sep;49(3):724–730. doi: 10.1128/iai.49.3.724-730.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Brummer E., Stevens D. A. Candidacidal mechanisms of peritoneal macrophages activated with lymphokines or gamma-interferon. J Med Microbiol. 1989 Mar;28(3):173–181. doi: 10.1099/00222615-28-3-173. [DOI] [PubMed] [Google Scholar]
  58. Brummer E., Sugar A. M., Stevens D. A. Enhanced oxidative burst in immunologically activated but not elicited polymorphonuclear leukocytes correlates with fungicidal activity. Infect Immun. 1985 Aug;49(2):396–401. doi: 10.1128/iai.49.2.396-401.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Budtz-Jörgensen E. Etiology, pathogenesis, therapy, and prophylaxis of oral yeast infections. Acta Odontol Scand. 1990 Feb;48(1):61–69. doi: 10.3109/00016359009012735. [DOI] [PubMed] [Google Scholar]
  60. Cantorna M. T., Balish E. Acquired immunity to systemic candidiasis in immunodeficient mice. J Infect Dis. 1991 Nov;164(5):936–943. doi: 10.1093/infdis/164.5.936. [DOI] [PubMed] [Google Scholar]
  61. Cantorna M. T., Balish E. Mucosal and systemic candidiasis in congenitally immunodeficient mice. Infect Immun. 1990 Apr;58(4):1093–1100. doi: 10.1128/iai.58.4.1093-1100.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Cantorna M. T., Balish E. Role of CD4+ lymphocytes in resistance to mucosal candidiasis. Infect Immun. 1991 Jul;59(7):2447–2455. doi: 10.1128/iai.59.7.2447-2455.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Cantorna M., Mook D., Balish E. Resistance of congenitally immunodeficient gnotobiotic mice to vaginal candidiasis. Infect Immun. 1990 Nov;58(11):3813–3815. doi: 10.1128/iai.58.11.3813-3815.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Cardell S., Sander B., Möller G. Helper interleukins are produced by both CD4 and CD8 splenic T cells after mitogen stimulation. Eur J Immunol. 1991 Oct;21(10):2495–2500. doi: 10.1002/eji.1830211028. [DOI] [PubMed] [Google Scholar]
  65. Carlson E. Effect of strain of Staphylococcus aureus on synergism with Candida albicans resulting in mouse mortality and morbidity. Infect Immun. 1983 Oct;42(1):285–292. doi: 10.1128/iai.42.1.285-292.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Carlson E. Enhancement by Candida albicans of Staphylococcus aureus, Serratia marcescens, and Streptococcus faecalis in the establishment of infection in mice. Infect Immun. 1983 Jan;39(1):193–197. doi: 10.1128/iai.39.1.193-197.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Carlson E. Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality. Infect Immun. 1982 Dec;38(3):921–924. doi: 10.1128/iai.38.3.921-924.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Carrow E. W., Domer J. E. Immunoregulation in experimental murine candidiasis: specific suppression induced by Candida albicans cell wall glycoprotein. Infect Immun. 1985 Jul;49(1):172–181. doi: 10.1128/iai.49.1.172-181.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Cech P., Lehrer R. I. Heterogeneity of human neutrophil phagolysosomes: functional consequences for candidacidal activity. Blood. 1984 Jul;64(1):147–151. [PubMed] [Google Scholar]
  70. Cenci E., Bartocci A., Puccetti P., Mocci S., Stanley E. R., Bistoni F. Macrophage colony-stimulating factor in murine candidiasis: serum and tissue levels during infection and protective effect of exogenous administration. Infect Immun. 1991 Mar;59(3):868–872. doi: 10.1128/iai.59.3.868-872.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Cenci E., Mencacci A., Spaccapelo R., Tonnetti L., Mosci P., Enssle K. H., Puccetti P., Romani L., Bistoni F. T helper cell type 1 (Th1)- and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 development. J Infect Dis. 1995 May;171(5):1279–1288. doi: 10.1093/infdis/171.5.1279. [DOI] [PubMed] [Google Scholar]
  72. Cenci E., Romani L., Mencacci A., Spaccapelo R., Schiaffella E., Puccetti P., Bistoni F. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur J Immunol. 1993 May;23(5):1034–1038. doi: 10.1002/eji.1830230508. [DOI] [PubMed] [Google Scholar]
  73. Cenci E., Romani L., Vecchiarelli A., Puccetti P., Bistoni F. Role of L3T4+ lymphocytes in protective immunity to systemic Candida albicans infection in mice. Infect Immun. 1989 Nov;57(11):3581–3587. doi: 10.1128/iai.57.11.3581-3587.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Cenci E., Romani L., Vecchiarelli A., Puccetti P., Bistoni F. T cell subsets and IFN-gamma production in resistance to systemic candidosis in immunized mice. J Immunol. 1990 Jun 1;144(11):4333–4339. [PubMed] [Google Scholar]
  75. Chakir J., Côté L., Coulombe C., Deslauriers N. Differential pattern of infection and immune response during experimental oral candidiasis in BALB/c and DBA/2 (H-2d) mice. Oral Microbiol Immunol. 1994 Apr;9(2):88–94. doi: 10.1111/j.1399-302x.1994.tb00040.x. [DOI] [PubMed] [Google Scholar]
  76. Cheers C., Waller R. Activated macrophages in congenitally athymic "nude mice" and in lethally irradiate mice. J Immunol. 1975 Sep;115(3):844–847. [PubMed] [Google Scholar]
  77. Chensue S. W., Warmington K. S., Hershey S. D., Terebuh P. D., Othman M., Kunkel S. L. Evolving T cell responses in murine schistosomiasis. Th2 cells mediate secondary granulomatous hypersensitivity and are regulated by CD8+ T cells in vivo. J Immunol. 1993 Aug 1;151(3):1391–1400. [PubMed] [Google Scholar]
  78. Cockayne A., Odds F. C. Interactions of Candida albicans yeast cells, germ tubes and hyphae with human polymorphonuclear leucocytes in vitro. J Gen Microbiol. 1984 Mar;130(3):465–471. doi: 10.1099/00221287-130-3-465. [DOI] [PubMed] [Google Scholar]
  79. Cohen I. R., Young D. B. Autoimmunity, microbial immunity and the immunological homunculus. Immunol Today. 1991 Apr;12(4):105–110. doi: 10.1016/0167-5699(91)90093-9. [DOI] [PubMed] [Google Scholar]
  80. Coker L. A., 3rd, Mercadal C. M., Rouse B. T., Moore R. N. Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis. J Leukoc Biol. 1992 Mar;51(3):305–306. doi: 10.1002/jlb.51.3.305. [DOI] [PubMed] [Google Scholar]
  81. Costantino P. J., Gare N. F., Warmington J. R. Humoral immune responses to systemic Candida albicans infection in inbred mouse strains. Immunol Cell Biol. 1995 Apr;73(2):125–133. doi: 10.1038/icb.1995.20. [DOI] [PubMed] [Google Scholar]
  82. Croft M., Carter L., Swain S. L., Dutton R. W. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med. 1994 Nov 1;180(5):1715–1728. doi: 10.1084/jem.180.5.1715. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Cuff C. F., Packer B. J., Rogers T. J. A further characterization of Candida albicans-induced suppressor B-cell activity. Immunology. 1989 Sep;68(1):80–86. [PMC free article] [PubMed] [Google Scholar]
  84. Cuff C. F., Packer B., Rivas V., Rogers C. M., Cassone A., Donnelly R., Rogers T. J. Induction of immunosuppressive B-lymphocytes with components of Candida albicans. Adv Exp Med Biol. 1988;239:367–378. doi: 10.1007/978-1-4757-5421-6_35. [DOI] [PubMed] [Google Scholar]
  85. Cuff C. F., Rogers C. M., Lamb B. J., Rogers T. J. Induction of suppressor cells in vitro by Candida albicans. Cell Immunol. 1986 Jun;100(1):47–56. doi: 10.1016/0008-8749(86)90005-5. [DOI] [PubMed] [Google Scholar]
  86. Cuff C. F., Taub D. D., Rogers T. J. The induction of T-suppressor cells with a soluble extract of Candida albicans. Cell Immunol. 1989 Aug;122(1):71–82. doi: 10.1016/0008-8749(89)90149-4. [DOI] [PubMed] [Google Scholar]
  87. Cutler J. E. Acute systemic candidiasis in normal and congenitally thymic-deficient (nude) mice. J Reticuloendothel Soc. 1976 Feb;19(2):121–124. [PubMed] [Google Scholar]
  88. Cutler J. E., Lloyd R. K. Enhanced antibody responses induced by Candida albicans in mice. Infect Immun. 1982 Dec;38(3):1102–1108. doi: 10.1128/iai.38.3.1102-1108.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Danley D. L., Hilger A. E. Stimulation of oxidative metabolism in murine polymorphonuclear leukocytes by unopsonized fungal cells: evidence for a mannose-specific mechanism. J Immunol. 1981 Aug;127(2):551–556. [PubMed] [Google Scholar]
  90. Danley D. L., Polakoff J. Rapid killing of monocytes in vitro by Candida albicans yeast cells. Infect Immun. 1986 Jan;51(1):307–313. doi: 10.1128/iai.51.1.307-313.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Decker T., Baccarini M., Lohmann-Matthes M. L. Liver-associated macrophage precursors as natural cytotoxic effectors against Candida albicans and Yac-1 cells. Eur J Immunol. 1986 Jun;16(6):693–699. doi: 10.1002/eji.1830160618. [DOI] [PubMed] [Google Scholar]
  92. Decker T., Lohmann-Matthes M. L., Baccarini M. Heterogeneous activity of immature and mature cells of the murine monocyte-macrophage lineage derived from different anatomical districts against yeast-phase Candida albicans. Infect Immun. 1986 Nov;54(2):477–486. doi: 10.1128/iai.54.2.477-486.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  93. Desmond F. B., Eastcott D. F., Anyon C. P. A study of candida in one thousand and seven women. N Z Med J. 1971 Jan;73(464):9–13. [PubMed] [Google Scholar]
  94. Diamond R. D., Haudenschild C. C. Monocyte-mediated serum-independent damage to hyphal and pseudohyphal forms of Candida albicans in vitro. J Clin Invest. 1981 Jan;67(1):173–182. doi: 10.1172/JCI110010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Diamond R. D., Lyman C. A., Wysong D. R. Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro. J Clin Invest. 1991 Feb;87(2):711–720. doi: 10.1172/JCI115050. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Djeu J. Y., Blanchard D. K., Halkias D., Friedman H. Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor. J Immunol. 1986 Nov 1;137(9):2980–2984. [PubMed] [Google Scholar]
  97. Djeu J. Y., Blanchard D. K. Regulation of human polymorphonuclear neutrophil (PMN) activity against Candida albicans by large granular lymphocytes via release of a PMN-activating factor. J Immunol. 1987 Oct 15;139(8):2761–2767. [PubMed] [Google Scholar]
  98. Djeu J. Y., Blanchard D. K., Richards A. L., Friedman H. Tumor necrosis factor induction by Candida albicans from human natural killer cells and monocytes. J Immunol. 1988 Dec 1;141(11):4047–4052. [PubMed] [Google Scholar]
  99. Djeu J. Y. Cytokines and anti-fungal immunity. Adv Exp Med Biol. 1992;319:217–223. doi: 10.1007/978-1-4615-3434-1_22. [DOI] [PubMed] [Google Scholar]
  100. Djeu J. Y., Liu J. H., Wei S., Rui H., Pearson C. A., Leonard W. J., Blanchard D. K. Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2. J Immunol. 1993 Feb 1;150(3):960–970. [PubMed] [Google Scholar]
  101. Djeu J. Y., Matsushima K., Oppenheim J. J., Shiotsuki K., Blanchard D. K. Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8. J Immunol. 1990 Mar 15;144(6):2205–2210. [PubMed] [Google Scholar]
  102. Djeu J. Y., Serbousek D., Blanchard D. K. Release of tumor necrosis factor by human polymorphonuclear leukocytes. Blood. 1990 Oct 1;76(7):1405–1409. [PubMed] [Google Scholar]
  103. Domer J. E. Candida cell wall mannan: a polysaccharide with diverse immunologic properties. Crit Rev Microbiol. 1989;17(1):33–51. doi: 10.3109/10408418909105721. [DOI] [PubMed] [Google Scholar]
  104. Domer J. E., Garner R. E., Befidi-Mengue R. N. Mannan as an antigen in cell-mediated immunity (CMI) assays and as a modulator of mannan-specific CMI. Infect Immun. 1989 Mar;57(3):693–700. doi: 10.1128/iai.57.3.693-700.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Domer J. E., Human L. G., Andersen G. B., Rudbach J. A., Asherson G. L. Abrogation of suppression of delayed hypersensitivity induced by Candida albicans-derived mannan by treatment with monophosphoryl lipid A. Infect Immun. 1993 May;61(5):2122–2130. doi: 10.1128/iai.61.5.2122-2130.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Domer J. E. Intragastric colonization of infant mice with Candida albicans induces systemic immunity demonstrable upon challenge as adults. J Infect Dis. 1988 May;157(5):950–958. doi: 10.1093/infdis/157.5.950. [DOI] [PubMed] [Google Scholar]
  107. Domer J. E., Stashak P. W., Elkins K., Prescott B., Caldes G., Baker P. J. Separation of immunomodulatory effects of mannan from Candida albicans into stimulatory and suppressive components. Cell Immunol. 1986 Sep;101(2):403–414. doi: 10.1016/0008-8749(86)90153-x. [DOI] [PubMed] [Google Scholar]
  108. Domer J., Elkins K., Ennist D., Baker P. Modulation of immune responses by surface polysaccharides of Candida albicans. Rev Infect Dis. 1988 Jul-Aug;10 (Suppl 2):S419–S422. doi: 10.1093/cid/10.supplement_2.s419. [DOI] [PubMed] [Google Scholar]
  109. Dunstone M. The common infectious diseases in Australia. A report from the australian general practitioner morbidity and prescribing survey. Med J Aust. 1976 Jan 17;1(3):57–60. [PubMed] [Google Scholar]
  110. Durandy A., Fischer A., Le Deist F., Drouhet E., Griscelli C. Mannan-specific and mannan-induced T-cell suppressive activity in patients with chronic mucocutaneous candidiasis. J Clin Immunol. 1987 Sep;7(5):400–409. doi: 10.1007/BF00917018. [DOI] [PubMed] [Google Scholar]
  111. Edwards J. E., Jr, Rotrosen D., Fontaine J. W., Haudenschild C. C., Diamond R. D. Neutrophil-mediated protection of cultured human vascular endothelial cells from damage by growing Candida albicans hyphae. Blood. 1987 May;69(5):1450–1457. [PubMed] [Google Scholar]
  112. Ekenna O., Sherertz R. J. Factors affecting colonization and dissemination of Candida albicans from the gastrointestinal tract of mice. Infect Immun. 1987 Jul;55(7):1558–1563. doi: 10.1128/iai.55.7.1558-1563.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  113. Enelow R. I., Sullivan G. W., Carper H. T., Mandell G. L. Cytokine-induced human multinucleated giant cells have enhanced candidacidal activity and oxidative capacity compared with macrophages. J Infect Dis. 1992 Sep;166(3):664–668. doi: 10.1093/infdis/166.3.664. [DOI] [PubMed] [Google Scholar]
  114. Enweani I. B., Ogbonna C. I., Kozak W. The incidence of candidiasis amongst the asymptomatic female students of the University of Jos, Nigeria. Mycopathologia. 1987 Sep;99(3):135–141. doi: 10.1007/BF00437435. [DOI] [PubMed] [Google Scholar]
  115. Fabian I., Kletter Y., Mor S., Geller-Bernstein C., Ben-Yaakov M., Volovitz B., Golde D. W. Activation of human eosinophil and neutrophil functions by haematopoietic growth factors: comparisons of IL-1, IL-3, IL-5 and GM-CSF. Br J Haematol. 1992 Feb;80(2):137–143. doi: 10.1111/j.1365-2141.1992.tb08890.x. [DOI] [PubMed] [Google Scholar]
  116. Fabian I., Shapira E., Gadish M., Kletter Y., Nagler A., Flidel O., Slavin S. Effects of human interleukin 3, macrophage and granulocyte-macrophage colony-stimulating factor on monocyte function following autologous bone marrow transplantation. Leuk Res. 1992 Jun-Jul;16(6-7):703–709. doi: 10.1016/0145-2126(92)90021-x. [DOI] [PubMed] [Google Scholar]
  117. Ferrante A. Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release. Infect Immun. 1989 Jul;57(7):2115–2122. doi: 10.1128/iai.57.7.2115-2122.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Ferrick D. A., Schrenzel M. D., Mulvania T., Hsieh B., Ferlin W. G., Lepper H. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature. 1995 Jan 19;373(6511):255–257. doi: 10.1038/373255a0. [DOI] [PubMed] [Google Scholar]
  119. Fidel P. L., Jr, Lynch M. E., Conaway D. H., Tait L., Sobel J. D. Mice immunized by primary vaginal Candida albicans infection develop acquired vaginal mucosal immunity. Infect Immun. 1995 Feb;63(2):547–553. doi: 10.1128/iai.63.2.547-553.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Fidel P. L., Jr, Lynch M. E., Redondo-Lopez V., Sobel J. D., Robinson R. Systemic cell-mediated immune reactivity in women with recurrent vulvovaginal candidiasis. J Infect Dis. 1993 Dec;168(6):1458–1465. doi: 10.1093/infdis/168.6.1458. [DOI] [PubMed] [Google Scholar]
  121. Fidel P. L., Jr, Lynch M. E., Sobel J. D. Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis. Infect Immun. 1993 Oct;61(10):4202–4207. doi: 10.1128/iai.61.10.4202-4207.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Fidel P. L., Jr, Lynch M. E., Sobel J. D. Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect Immun. 1993 May;61(5):1990–1995. doi: 10.1128/iai.61.5.1990-1995.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Fidel P. L., Jr, Lynch M. E., Sobel J. D. Circulating CD4 and CD8 T cells have little impact on host defense against experimental vaginal candidiasis. Infect Immun. 1995 Jul;63(7):2403–2408. doi: 10.1128/iai.63.7.2403-2408.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  124. Fidel P. L., Jr, Lynch M. E., Sobel J. D. Effects of preinduced Candida-specific systemic cell-mediated immunity on experimental vaginal candidiasis. Infect Immun. 1994 Mar;62(3):1032–1038. doi: 10.1128/iai.62.3.1032-1038.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. Fischer A., Ballet J. J., Griscelli C. Specific inhibition of in vitro Candida-induced lymphocyte proliferation by polysaccharidic antigens present in the serum of patients with chronic mucocutaneous candidiasis. J Clin Invest. 1978 Nov;62(5):1005–1013. doi: 10.1172/JCI109204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Fong T. A., Mosmann T. R. Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines. J Immunol. 1990 Mar 1;144(5):1744–1752. [PubMed] [Google Scholar]
  127. Franklyn K. M., Warmington J. R., Ott A. K., Ashman R. B. An immunodominant antigen of Candida albicans shows homology to the enzyme enolase. Immunol Cell Biol. 1990 Jun;68(Pt 3):173–178. doi: 10.1038/icb.1990.24. [DOI] [PubMed] [Google Scholar]
  128. Futenma M., Kawakami K., Saito A. Production of tumor necrosis factor-alpha in granulocytopenic mice with pulmonary candidiasis and its modification with granulocyte colony-stimulating factor. Microbiol Immunol. 1995;39(6):411–417. doi: 10.1111/j.1348-0421.1995.tb02221.x. [DOI] [PubMed] [Google Scholar]
  129. Gajewski T. F., Schell S. R., Nau G., Fitch F. W. Regulation of T-cell activation: differences among T-cell subsets. Immunol Rev. 1989 Oct;111:79–110. doi: 10.1111/j.1600-065x.1989.tb00543.x. [DOI] [PubMed] [Google Scholar]
  130. Garner R. E., Childress A. M., Human L. G., Domer J. E. Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells. Infect Immun. 1990 Aug;58(8):2613–2620. doi: 10.1128/iai.58.8.2613-2620.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Garner R. E., Domer J. E. Lack of effect of Candida albicans mannan on development of protective immune responses in experimental murine candidiasis. Infect Immun. 1994 Feb;62(2):738–741. doi: 10.1128/iai.62.2.738-741.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Garner R. E., Kuruganti U., Czarniecki C. W., Chiu H. H., Domer J. E. In vivo immune responses to Candida albicans modified by treatment with recombinant murine gamma interferon. Infect Immun. 1989 Jun;57(6):1800–1808. doi: 10.1128/iai.57.6.1800-1808.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Garner R. E., Rubanowice K., Sawyer R. T., Hudson J. A. Secretion of TNF-alpha by alveolar macrophages in response to Candida albicans mannan. J Leukoc Biol. 1994 Feb;55(2):161–168. doi: 10.1002/jlb.55.2.161. [DOI] [PubMed] [Google Scholar]
  134. Gatenby P. A. Reduced CD4+ T cells and candidiasis in absence of HIV infection. Lancet. 1989 May 6;1(8645):1027–1028. doi: 10.1016/s0140-6736(89)92677-9. [DOI] [PubMed] [Google Scholar]
  135. Gauchat J. F., Gauchat D., De Weck A. L., Stadler B. M. Cytokine mRNA levels in antigen-stimulated peripheral blood mononuclear cells. Eur J Immunol. 1989 Jun;19(6):1079–1085. doi: 10.1002/eji.1830190618. [DOI] [PubMed] [Google Scholar]
  136. Giger D. K., Domer J. E., Moser S. A., McQuitty J. T., Jr Experimental murine candidiasis: pathological and immune responses in T-lymphocyte-depleted mice. Infect Immun. 1978 Sep;21(3):729–737. doi: 10.1128/iai.21.3.729-737.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Gilmore B. J., Retsinas E. M., Lorenz J. S., Hostetter M. K. An iC3b receptor on Candida albicans: structure, function, and correlates for pathogenicity. J Infect Dis. 1988 Jan;157(1):38–46. doi: 10.1093/infdis/157.1.38. [DOI] [PubMed] [Google Scholar]
  138. Gough P. M., Warnock D. W., Richardson M. D., Mansell N. J., King J. M. IgA and IgG antibodies to Candida albicans in the genital tract secretions of women with or without vaginal candidosis. Sabouraudia. 1984;22(4):265–271. [PubMed] [Google Scholar]
  139. Greenfield R. A., Abrams V. L., Crawford D. L., Kuhls T. L. Effect of abrogation of natural killer cell activity on the course of candidiasis induced by intraperitoneal administration and gastrointestinal candidiasis in mice with severe combined immunodeficiency. Infect Immun. 1993 Jun;61(6):2520–2525. doi: 10.1128/iai.61.6.2520-2525.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Guerder S., Matzinger P. A fail-safe mechanism for maintaining self-tolerance. J Exp Med. 1992 Aug 1;176(2):553–564. doi: 10.1084/jem.176.2.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  141. Gustafson K. S., Vercellotti G. M., Bendel C. M., Hostetter M. K. Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium. J Clin Invest. 1991 Jun;87(6):1896–1902. doi: 10.1172/JCI115214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  142. Hall N. R., McGillis J. P., Spangelo B. L., Goldstein A. L. Evidence that thymosins and other biologic response modifiers can function as neuroactive immunotransmitters. J Immunol. 1985 Aug;135(2 Suppl):806s–811s. [PubMed] [Google Scholar]
  143. Hamilton J. R., Overall J. C., Glasgow L. A. Synergistic effect on mortality in mice with murine cytomegalovirus and Pseudomonas aeruginosa, Staphylococcus aureus, or Candida albicans infections. Infect Immun. 1976 Oct;14(4):982–989. doi: 10.1128/iai.14.4.982-989.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Hamilton J. R., Overall J. C., Jr, Glasgow L. A. Synergistic infection with murine cytomegalovirus and Candida albicans in mice. J Infect Dis. 1977 Jun;135(6):918–924. doi: 10.1093/infdis/135.6.918. [DOI] [PubMed] [Google Scholar]
  145. Hector R. F., Domer J. E., Carrow E. W. Immune responses to Candida albicans in genetically distinct mice. Infect Immun. 1982 Dec;38(3):1020–1028. doi: 10.1128/iai.38.3.1020-1028.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  146. Heinzel F. P., Sadick M. D., Holaday B. J., Coffman R. L., Locksley R. M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 1989 Jan 1;169(1):59–72. doi: 10.1084/jem.169.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  147. Henderson D. C., Rippin J. J. Stimulus-dependent production of cytokines and pterins by peripheral blood mononuclear cells. Immunol Lett. 1995 Feb;45(1-2):29–34. doi: 10.1016/0165-2478(94)00222-d. [DOI] [PubMed] [Google Scholar]
  148. Hidore M. R., Nabavi N., Sonleitner F., Murphy J. W. Murine natural killer cells are fungicidal to Cryptococcus neoformans. Infect Immun. 1991 May;59(5):1747–1754. doi: 10.1128/iai.59.5.1747-1754.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Hilger A. E., Danley D. L. Alteration of polymorphonuclear leukocyte activity by viable Candida albicans. Infect Immun. 1980 Mar;27(3):714–720. doi: 10.1128/iai.27.3.714-720.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  150. Hsieh C. S., Macatonia S. E., O'Garra A., Murphy K. M. T cell genetic background determines default T helper phenotype development in vitro. J Exp Med. 1995 Feb 1;181(2):713–721. doi: 10.1084/jem.181.2.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  151. Huang K. Y., Kind P. D., Jagoda E. M., Goldstein A. L. Thymosin treatment modulates production of interferon. J Interferon Res. 1981;1(3):411–420. doi: 10.1089/jir.1981.1.411. [DOI] [PubMed] [Google Scholar]
  152. Hume D. A., Denkins Y. The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice. Lymphokine Cytokine Res. 1992 Apr;11(2):95–98. [PubMed] [Google Scholar]
  153. Hurley R., De Louvois J. Candida vaginitis. Postgrad Med J. 1979 Sep;55(647):645–647. doi: 10.1136/pgmj.55.647.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Hurley R. Inveterate vaginal thrush. Practitioner. 1975 Dec;215(1290):753–756. [PubMed] [Google Scholar]
  155. Høgåsen A. K., Abrahamsen T. G., Gaustad P. Various Candida and Torulopsis species differ in their ability to induce the production of C3, factor B and granulocyte-macrophage colony-stimulating factor (GM-CSF) in human monocyte cultures. J Med Microbiol. 1995 Apr;42(4):291–298. doi: 10.1099/00222615-42-4-291. [DOI] [PubMed] [Google Scholar]
  156. Høgåsen A. K., Abrahamsen T. G. Increased C3 production in human monocytes after stimulation with Candida albicans is suppressed by granulocyte-macrophage colony-stimulating factor. Infect Immun. 1993 May;61(5):1779–1785. doi: 10.1128/iai.61.5.1779-1785.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Høgåsen A. K., Hestdal K., Høgåsen K., Abrahamsen T. G. Transforming growth factor beta modulates C3 and factor B biosynthesis and complement receptor 3 expression in cultured human monocytes. J Leukoc Biol. 1995 Feb;57(2):287–296. doi: 10.1002/jlb.57.2.287. [DOI] [PubMed] [Google Scholar]
  158. Ishiguro A., Homma M., Sukai T., Higashide K., Torii S., Tanaka K. Immunoblotting analysis of sera from patients with candidal vaginitis and healthy females. J Med Vet Mycol. 1992;30(4):281–292. doi: 10.1080/02681219280000371. [DOI] [PubMed] [Google Scholar]
  159. Jeganathan S., Lin C. C. Denture stomatitis--a review of the aetiology, diagnosis and management. Aust Dent J. 1992 Apr;37(2):107–114. doi: 10.1111/j.1834-7819.1992.tb03046.x. [DOI] [PubMed] [Google Scholar]
  160. Jensen J., Vazquez-Torres A., Balish E. Poly(I.C)-induced interferons enhance susceptibility of SCID mice to systemic candidiasis. Infect Immun. 1992 Nov;60(11):4549–4557. doi: 10.1128/iai.60.11.4549-4557.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  161. Jensen J., Warner T., Balish E. Resistance of SCID mice to Candida albicans administered intravenously or colonizing the gut: role of polymorphonuclear leukocytes and macrophages. J Infect Dis. 1993 Apr;167(4):912–919. doi: 10.1093/infdis/167.4.912. [DOI] [PubMed] [Google Scholar]
  162. Jensen J., Warner T., Balish E. The role of phagocytic cells in resistance to disseminated candidiasis in granulocytopenic mice. J Infect Dis. 1994 Oct;170(4):900–905. doi: 10.1093/infdis/170.4.900. [DOI] [PubMed] [Google Scholar]
  163. Jeremias J., Kalo-Klein A., Witkin S. S. Individual differences in tumour necrosis factor and interleukin-1 production induced by viable and heat-killed Candida albicans. J Med Vet Mycol. 1991;29(3):157–163. doi: 10.1080/02681219180000261. [DOI] [PubMed] [Google Scholar]
  164. Jones-Carson J., Vazquez-Torres A., Balish E. Defective killing of Candida albicans hyphae by neutrophils from beige mice. J Infect Dis. 1995 Jun;171(6):1664–1667. doi: 10.1093/infdis/171.6.1664. [DOI] [PubMed] [Google Scholar]
  165. Jones-Carson J., Vazquez-Torres A., van der Heyde H. C., Warner T., Wagner R. D., Balish E. Gamma delta T cell-induced nitric oxide production enhances resistance to mucosal candidiasis. Nat Med. 1995 Jun;1(6):552–557. doi: 10.1038/nm0695-552. [DOI] [PubMed] [Google Scholar]
  166. Jontell M., Scheynius A., Ohman S. C., Magnusson B. Expression of Class II transplantation antigens by epithelial cells in oral candidosis, oral lichen planus and gingivitis. J Oral Pathol. 1986 Oct;15(9):484–488. doi: 10.1111/j.1600-0714.1986.tb00663.x. [DOI] [PubMed] [Google Scholar]
  167. Jouault T., Bernigaud A., Lepage G., Trinel P. A., Poulain D. The Candida albicans phospholipomannan induces in vitro production of tumour necrosis factor-alpha from human and murine macrophages. Immunology. 1994 Oct;83(2):268–273. [PMC free article] [PubMed] [Google Scholar]
  168. Kagaya K., Fukazawa Y. Murine defense mechanism against Candida albicans infection. II. Opsonization, phagocytosis, and intracellular killing of C. albicans. Microbiol Immunol. 1981;25(8):807–818. doi: 10.1111/j.1348-0421.1981.tb00084.x. [DOI] [PubMed] [Google Scholar]
  169. Kagaya K., Shinoda T., Fukazawa Y. Murine defense mechanism against Candida albicans infection. I. Collaboration of cell-mediated and humoral immunities in protection against systemic C. albicans infection. Microbiol Immunol. 1981;25(7):647–654. doi: 10.1111/j.1348-0421.1981.tb00068.x. [DOI] [PubMed] [Google Scholar]
  170. Kalo-Klein A., Witkin S. S. Candida albicans: cellular immune system interactions during different stages of the menstrual cycle. Am J Obstet Gynecol. 1989 Nov;161(5):1132–1136. doi: 10.1016/0002-9378(89)90649-2. [DOI] [PubMed] [Google Scholar]
  171. Kalo-Klein A., Witkin S. S. Regulation of the immune response to Candida albicans by monocytes and progesterone. Am J Obstet Gynecol. 1991 May;164(5 Pt 1):1351–1354. doi: 10.1016/0002-9378(91)90712-z. [DOI] [PubMed] [Google Scholar]
  172. Karbassi A., Becker J. M., Foster J. S., Moore R. N. Enhanced killing of Candida albicans by murine macrophages treated with macrophage colony-stimulating factor: evidence for augmented expression of mannose receptors. J Immunol. 1987 Jul 15;139(2):417–421. [PubMed] [Google Scholar]
  173. Kawabe Y., Ochi A. Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice. J Exp Med. 1990 Oct 1;172(4):1065–1070. doi: 10.1084/jem.172.4.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  174. Kawai K., Ohashi P. S. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature. 1995 Mar 2;374(6517):68–69. doi: 10.1038/374068a0. [DOI] [PubMed] [Google Scholar]
  175. Kelso A., Troutt A. B., Maraskovsky E., Gough N. M., Morris L., Pech M. H., Thomson J. A. Heterogeneity in lymphokine profiles of CD4+ and CD8+ T cells and clones activated in vivo and in vitro. Immunol Rev. 1991 Oct;123:85–114. doi: 10.1111/j.1600-065x.1991.tb00607.x. [DOI] [PubMed] [Google Scholar]
  176. Khwaja A., Johnson B., Addison I. E., Yong K., Ruthven K., Abramson S., Linch D. C. In vivo effects of macrophage colony-stimulating factor on human monocyte function. Br J Haematol. 1991 Jan;77(1):25–31. doi: 10.1111/j.1365-2141.1991.tb07943.x. [DOI] [PubMed] [Google Scholar]
  177. Kim M. H., Rodey G. E., Good R. A., Chilgren R. A., Quie P. G. Defective candidacidal capacity of polymorphonuclear leukocytes in chronic granulomatous disease of childhood. J Pediatr. 1969 Aug;75(2):300–303. doi: 10.1016/s0022-3476(69)80403-8. [DOI] [PubMed] [Google Scholar]
  178. Kirkpatrick C. H. Chronic mucocutaneous candidiasis. J Am Acad Dermatol. 1994 Sep;31(3 Pt 2):S14–S17. doi: 10.1016/s0190-9622(08)81260-1. [DOI] [PubMed] [Google Scholar]
  179. Kirkpatrick C. H. Chronic mucocutaneous candidiasis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):448–456. doi: 10.1007/BF01964059. [DOI] [PubMed] [Google Scholar]
  180. Kirkpatrick C. H. Host factors in defense against fungal infections. Am J Med. 1984 Oct 30;77(4D):1–12. [PubMed] [Google Scholar]
  181. Klein R. S., Harris C. A., Small C. B., Moll B., Lesser M., Friedland G. H. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med. 1984 Aug 9;311(6):354–358. doi: 10.1056/NEJM198408093110602. [DOI] [PubMed] [Google Scholar]
  182. Kouttab N. M., Goldstein A. L., Lu M., Lu L., Campbell B., Maizel A. L. Production of human B and T cell growth factors is enhanced by thymic hormones. Immunopharmacology. 1988 Sep-Oct;16(2):97–105. doi: 10.1016/0162-3109(88)90018-5. [DOI] [PubMed] [Google Scholar]
  183. Krause W., Matheis H., Wulf K. Fungaemia and funguria after oral administration of Candida albicans. Lancet. 1969 Mar 22;1(7595):598–599. doi: 10.1016/s0140-6736(69)91534-7. [DOI] [PubMed] [Google Scholar]
  184. Kroemer G., Moreno de Alborán I., Gonzalo J. A., Martínez C. Immunoregulation by cytokines. Crit Rev Immunol. 1993;13(2):163–191. [PubMed] [Google Scholar]
  185. Kubo A., Sasada M., Nishimura T., Moriguchi T., Kakita T., Yamamoto K., Uchino H. Oxygen radical generation by polymorphonuclear leucocytes of beige mice. Clin Exp Immunol. 1987 Dec;70(3):658–663. [PMC free article] [PubMed] [Google Scholar]
  186. Kullberg B. J., van 't Wout J. W., Hoogstraten C., van Furth R. Recombinant interferon-gamma enhances resistance to acute disseminated Candida albicans infection in mice. J Infect Dis. 1993 Aug;168(2):436–443. doi: 10.1093/infdis/168.2.436. [DOI] [PubMed] [Google Scholar]
  187. Kurlander R. J., Hoffman M., Kratz S. S., Gates J. Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity. Cell Immunol. 1989 Oct 1;123(1):9–22. doi: 10.1016/0008-8749(89)90264-5. [DOI] [PubMed] [Google Scholar]
  188. Lacasse M., Fortier C., Chakir J., Côté L., Deslauriers N. Acquired resistance and persistence of Candida albicans following oral candidiasis in the mouse: a model of the carrier state in humans. Oral Microbiol Immunol. 1993 Oct;8(5):313–318. doi: 10.1111/j.1399-302x.1993.tb00580.x. [DOI] [PubMed] [Google Scholar]
  189. Lal S., Mitsuyama M., Miyata M., Ogata N., Amako K., Nomoto K. Pulmonary defence mechanism in mice. A comparative role of alveolar macrophages and polymorphonuclear cells against infection with Candida albicans. J Clin Lab Immunol. 1986 Mar;19(3):127–133. [PubMed] [Google Scholar]
  190. Lehmann P. F. Immunology of fungal infections in animals. Vet Immunol Immunopathol. 1985 Oct;10(1):33–69. doi: 10.1016/0165-2427(85)90038-8. [DOI] [PubMed] [Google Scholar]
  191. Lehrer R. I., Cline M. J. Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer. Cancer. 1971 May;27(5):1211–1217. doi: 10.1002/1097-0142(197105)27:5<1211::aid-cncr2820270528>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  192. Lombardi G., Di Massimo A. M., Del Gallo F., Vismara D., Piccolella E., Pugliese O., Colizzi V. Mechanism of action of an antigen nonspecific inhibitory factor produced by human T cells stimulated by MPPS and PPD. Cell Immunol. 1986 Apr 1;98(2):434–443. doi: 10.1016/0008-8749(86)90302-3. [DOI] [PubMed] [Google Scholar]
  193. Lombardi G., Vismara D., Piccolella E., Colizzi V., Asherson G. L. A non-specific inhibitor produced by Candida albicans activated T cells impairs cell proliferation by inhibiting interleukin-1 production. Clin Exp Immunol. 1985 May;60(2):303–310. [PMC free article] [PubMed] [Google Scholar]
  194. Louie A., Baltch A. L., Smith R. P., Franke M. A., Ritz W. J., Singh J. K., Gordon M. A. Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis. Infect Immun. 1994 Jul;62(7):2761–2772. doi: 10.1128/iai.62.7.2761-2772.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  195. Lyon F. L., Hector R. F., Domer J. E. Innate and acquired immune responses against Candida albicans in congenic B10.D2 mice with deficiency of the C5 complement component. J Med Vet Mycol. 1986 Oct;24(5):359–367. doi: 10.1080/02681218680000551. [DOI] [PubMed] [Google Scholar]
  196. Mahanty S., Greenfield R. A., Joyce W. A., Kincade P. W. Inoculation candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun. 1988 Dec;56(12):3162–3166. doi: 10.1128/iai.56.12.3162-3166.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  197. Marconi P., Scaringi L., Tissi L., Boccanera M., Bistoni F., Bonmassar E., Cassone A. Induction of natural killer cell activity by inactivated Candida albicans in mice. Infect Immun. 1985 Oct;50(1):297–303. doi: 10.1128/iai.50.1.297-303.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  198. Marquis G., Montplaisir S., Pelletier M., Auger P., Lapp W. S. Genetics of resistance to infection with Candida albicans in mice. Br J Exp Pathol. 1988 Oct;69(5):651–660. [PMC free article] [PubMed] [Google Scholar]
  199. Marquis G., Montplaisir S., Pelletier M., Mousseau S., Auger P. Strain-dependent differences in susceptibility of mice to experimental candidosis. J Infect Dis. 1986 Nov;154(5):906–909. doi: 10.1093/infdis/154.5.906. [DOI] [PubMed] [Google Scholar]
  200. Maródi L., Forehand J. R., Johnston R. B., Jr Mechanisms of host defense against Candida species. II. Biochemical basis for the killing of Candida by mononuclear phagocytes. J Immunol. 1991 Apr 15;146(8):2790–2794. [PubMed] [Google Scholar]
  201. Maródi L., Johnston R. B., Jr Enhancement of macrophage candidacidal activity by interferon-gamma. Immunodeficiency. 1993;4(1-4):181–185. [PubMed] [Google Scholar]
  202. Maródi L., Káposzta R., Campbell D. E., Polin R. A., Csongor J., Johnston R. B., Jr Candidacidal mechanisms in the human neonate. Impaired IFN-gamma activation of macrophages in newborn infants. J Immunol. 1994 Dec 15;153(12):5643–5649. [PubMed] [Google Scholar]
  203. Maródi L., Schreiber S., Anderson D. C., MacDermott R. P., Korchak H. M., Johnston R. B., Jr Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors. J Clin Invest. 1993 Jun;91(6):2596–2601. doi: 10.1172/JCI116498. [DOI] [PMC free article] [PubMed] [Google Scholar]
  204. Mathur S., Mathur R. S., Goust J. M., Williamson H. O., Fudenberg H. H. Cyclic variations in white cell subpopulations in the human menstrual cycle: correlations with progesterone and estradiol. Clin Immunol Immunopathol. 1979 Jul;13(3):246–253. doi: 10.1016/0090-1229(79)90069-2. [DOI] [PubMed] [Google Scholar]
  205. Mathur S., Melchers J. T., 3rd, Ades E. W., Williamson H. O., Fudenberg H. H. Anti-ovarian and anti-lymphocyte antibodies in patients with chronic vaginal candidiasis. J Reprod Immunol. 1980 Dec;2(5):247–262. doi: 10.1016/0165-0378(80)90038-8. [DOI] [PubMed] [Google Scholar]
  206. Matsumoto M., Matsubara S., Matsuno T., Ono M., Yokota T. Protective effect of recombinant human granulocyte colony-stimulating factor (rG-CSF) against various microbial infections in neutropenic mice. Microbiol Immunol. 1990;34(9):765–773. doi: 10.1111/j.1348-0421.1990.tb01054.x. [DOI] [PubMed] [Google Scholar]
  207. Matthews R. C., Burnie J. P., Howat D., Rowland T., Walton F. Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis. Immunology. 1991 Sep;74(1):20–24. [PMC free article] [PubMed] [Google Scholar]
  208. Matthews R. C., Burnie J. P., Tabaqchali S. Immunoblot analysis of the serological response in systemic candidosis. Lancet. 1984 Dec 22;2(8417-8418):1415–1418. doi: 10.1016/s0140-6736(84)91618-0. [DOI] [PubMed] [Google Scholar]
  209. Matthews R., Burnie J., Smith D., Clark I., Midgley J., Conolly M., Gazzard B. Candida and AIDS: evidence for protective antibody. Lancet. 1988 Jul 30;2(8605):263–266. doi: 10.1016/s0140-6736(88)92547-0. [DOI] [PubMed] [Google Scholar]
  210. Matthews R., Burnie J. The role of hsp90 in fungal infection. Immunol Today. 1992 Sep;13(9):345–348. doi: 10.1016/0167-5699(92)90169-8. [DOI] [PubMed] [Google Scholar]
  211. Mayer C. L., Diamond R. D., Edwards J. E., Jr Recognition of binding sites on Candida albicans by monoclonal antibodies to human leukocyte antigens. Infect Immun. 1990 Nov;58(11):3765–3769. doi: 10.1128/iai.58.11.3765-3769.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  212. Mayer P., Schütze E., Lam C., Kricek F., Liehl E. Recombinant murine granulocyte-macrophage colony-stimulating factor augments neutrophil recovery and enhances resistance to infections in myelosuppressed mice. J Infect Dis. 1991 Mar;163(3):584–590. doi: 10.1093/infdis/163.3.584. [DOI] [PubMed] [Google Scholar]
  213. McNamara M. P., Wiessner J. H., Collins-Lech C., Hahn B. L., Sohnle P. G. Neutrophil death as a defence mechanism against Candida albicans infections. Lancet. 1988 Nov 19;2(8621):1163–1165. doi: 10.1016/s0140-6736(88)90234-6. [DOI] [PubMed] [Google Scholar]
  214. Meech R. J., Smith J. M., Chew T. Pathogenic mechanisms in recurrent genital candidosis in women. N Z Med J. 1985 Jan 23;98(771):1–5. [PubMed] [Google Scholar]
  215. Mencacci A., Romani L., Mosci P., Cenci E., Tonnetti L., Vecchiarelli A., Bistoni F. Low-dose streptozotocin-induced diabetes in mice. II. Susceptibility to Candida albicans infection correlates with the induction of a biased Th2-like antifungal response. Cell Immunol. 1993 Aug;150(1):36–44. doi: 10.1006/cimm.1993.1176. [DOI] [PubMed] [Google Scholar]
  216. Mencacci A., Torosantucci A., Spaccapelo R., Romani L., Bistoni F., Cassone A. A mannoprotein constituent of Candida albicans that elicits different levels of delayed-type hypersensitivity, cytokine production, and anticandidal protection in mice. Infect Immun. 1994 Dec;62(12):5353–5360. doi: 10.1128/iai.62.12.5353-5360.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  217. Mendling W., Koldovsky U. Immunological findings in patients with chronically recurrent vaginal candidosis and new therapeutic approaches. Mycoses. 1989 Aug;32(8):386–390. doi: 10.1111/j.1439-0507.1989.tb02268.x. [DOI] [PubMed] [Google Scholar]
  218. Meuwissen H. J., Rhee M. S., Rynes R. I., Pickering R. J. Phagocytosis, chemoluminescence, and intracellular killing of fungi by phagocytes from subjects with deficiency of the second component of complement. Int Arch Allergy Appl Immunol. 1982;68(1):22–27. doi: 10.1159/000233062. [DOI] [PubMed] [Google Scholar]
  219. Ming W. J., Bersani L., Mantovani A. Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes. J Immunol. 1987 Mar 1;138(5):1469–1474. [PubMed] [Google Scholar]
  220. Miyake T., Takeya K., Nomoto K., Muraoka S. Cellular elements in the resistance to candida infection in mice. I. Contribution of T lymphocytes and phagocytes at various stages of infection. Microbiol Immunol. 1977;21(12):703–725. doi: 10.1111/j.1348-0421.1977.tb00339.x. [DOI] [PubMed] [Google Scholar]
  221. Morelli R., Rosenberg L. T. Role of complement during experimental Candida infection in mice. Infect Immun. 1971 Apr;3(4):521–523. doi: 10.1128/iai.3.4.521-523.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  222. Morelli R., Rosenberg L. T. The role of complement in the phagocytosis of Candida albicans by mouse peripheral blood leukocytes. J Immunol. 1971 Aug;107(2):476–480. [PubMed] [Google Scholar]
  223. Morris L., Troutt A. B., McLeod K. S., Kelso A., Handman E., Aebischer T. Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis. Infect Immun. 1993 Aug;61(8):3459–3465. doi: 10.1128/iai.61.8.3459-3465.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  224. Morrison C. J., Brummer E., Isenberg R. A., Stevens D. A. Activation of murine polymorphonuclear neutrophils for fungicidal activity by recombinant gamma interferon. J Leukoc Biol. 1987 May;41(5):434–440. doi: 10.1002/jlb.41.5.434. [DOI] [PubMed] [Google Scholar]
  225. Mosci P., Vecchiarelli A., Cenci E., Puliti M., Bistoni F. Low-dose streptozotocin-induced diabetes in mice. I. Course of Candida albicans infection. Cell Immunol. 1993 Aug;150(1):27–35. doi: 10.1006/cimm.1993.1175. [DOI] [PubMed] [Google Scholar]
  226. Mosmann T. R., Coffman R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145–173. doi: 10.1146/annurev.iy.07.040189.001045. [DOI] [PubMed] [Google Scholar]
  227. Narayanan R., Joyce W. A., Greenfield R. A. Gastrointestinal candidiasis in a murine model of severe combined immunodeficiency syndrome. Infect Immun. 1991 Jun;59(6):2116–2119. doi: 10.1128/iai.59.6.2116-2119.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  228. Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983 Sep 1;158(3):670–689. doi: 10.1084/jem.158.3.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  229. Nelson R. D., Shibata N., Podzorski R. P., Herron M. J. Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action. Clin Microbiol Rev. 1991 Jan;4(1):1–19. doi: 10.1128/cmr.4.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  230. Nemunaitis J., Meyers J. D., Buckner C. D., Shannon-Dorcy K., Mori M., Shulman H., Bianco J. A., Higano C. S., Groves E., Storb R. Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections. Blood. 1991 Aug 15;78(4):907–913. [PubMed] [Google Scholar]
  231. Neta R., Salvin S. B. Resistance and susceptibility to infection in inbred murine strains. II. Variations in the effect of treatment with thymosin fraction 5 on the release of lymphokines in vivo. Cell Immunol. 1983 Jan;75(1):173–180. doi: 10.1016/0008-8749(83)90316-7. [DOI] [PubMed] [Google Scholar]
  232. Nohmi T., Abe S., Dobashi K., Tansho S., Yamaguchi H. Suppression of anti-Candida activity of murine neutrophils by progesterone in vitro: a possible mechanism in pregnant women's vulnerability to vaginal candidiasis. Microbiol Immunol. 1995;39(6):405–409. doi: 10.1111/j.1348-0421.1995.tb02220.x. [DOI] [PubMed] [Google Scholar]
  233. Nose Y., Komori K., Inouye H., Nomura K., Yamamura M., Tsuji K. Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen. Clin Exp Immunol. 1980 May;40(2):345–350. [PMC free article] [PubMed] [Google Scholar]
  234. Nose Y., Komori K., Inouye H., Nomura K., Yamamura M., Tsuji K. Role of macrophages in T lymphocyte response to Candida allergen in man with special reference to HLA-D and DR. Clin Exp Immunol. 1981 Jul;45(1):152–157. [PMC free article] [PubMed] [Google Scholar]
  235. Nugent K. M., Onofrio J. M. Pulmonary tissue resistance to Candida albicans in normal and in immunosuppressed mice. Am Rev Respir Dis. 1983 Nov;128(5):909–914. doi: 10.1164/arrd.1983.128.5.909. [DOI] [PubMed] [Google Scholar]
  236. Ochi A., Yuh K., Migita K., Kawabe Y. Effects of staphylococcal toxins on T-cell activity in vivo. Chem Immunol. 1992;55:115–136. [PubMed] [Google Scholar]
  237. Oh A. K., Franklyn K., Warmington J. R., Ashman R. B. A Candida-specific antibody in patients with vaginitis. Med J Aust. 1990 Apr 2;152(7):390–391. doi: 10.5694/j.1326-5377.1990.tb125254.x. [DOI] [PubMed] [Google Scholar]
  238. Ohman S. C., Jontell M., Jonsson R. Phenotypic characterization of mononuclear cells and class II antigen expression in angular cheilitis infected by Candida albicans or Staphylococcus aureus. Scand J Dent Res. 1989 Apr;97(2):178–185. doi: 10.1111/j.1600-0722.1989.tb01447.x. [DOI] [PubMed] [Google Scholar]
  239. Orme I. M., Roberts A. D., Griffin J. P., Abrams J. S. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J Immunol. 1993 Jul 1;151(1):518–525. [PubMed] [Google Scholar]
  240. Palma C., Cassone A., Serbousek D., Pearson C. A., Djeu J. Y. Lactoferrin release and interleukin-1, interleukin-6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: relationship to growth inhibition of Candida albicans. Infect Immun. 1992 Nov;60(11):4604–4611. doi: 10.1128/iai.60.11.4604-4611.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  241. Palma C., Serbousek D., Torosantucci A., Cassone A., Djeu J. Y. Identification of a mannoprotein fraction from Candida albicans that enhances human polymorphonuclear leukocyte (PMNL) functions and stimulates lactoferrin in PMNL inhibition of candidal growth. J Infect Dis. 1992 Nov;166(5):1103–1112. doi: 10.1093/infdis/166.5.1103. [DOI] [PubMed] [Google Scholar]
  242. Pankhurst C., Peakman M. Reduced CD4 + T cells and severe oral candidiasis in absence of HIV infection. Lancet. 1989 Mar 25;1(8639):672–672. doi: 10.1016/s0140-6736(89)92176-4. [DOI] [PubMed] [Google Scholar]
  243. Papadimitriou J. M., Ashman R. B. The pathogenesis of acute systemic candidiasis in a susceptible inbred mouse strain. J Pathol. 1986 Dec;150(4):257–265. doi: 10.1002/path.1711500405. [DOI] [PubMed] [Google Scholar]
  244. Parker J. C., Jr, McCloskey J. J., Solanki K. V., Goodman N. L. Candidosis: the most common postmortem cerebral mycosis in an endemic fungal area. Surg Neurol. 1976 Aug;6(2):123–128. [PubMed] [Google Scholar]
  245. Pecyk R. A., Fraser-Smith E. B., Matthews T. R. Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice. Infect Immun. 1989 Oct;57(10):3257–3258. doi: 10.1128/iai.57.10.3257-3258.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  246. Pereira H. A., Hosking C. S. The role of complement and antibody in opsonization and intracellular killing of Candida albicans. Clin Exp Immunol. 1984 Aug;57(2):307–314. [PMC free article] [PubMed] [Google Scholar]
  247. Pernis A., Gupta S., Gollob K. J., Garfein E., Coffman R. L., Schindler C., Rothman P. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science. 1995 Jul 14;269(5221):245–247. doi: 10.1126/science.7618088. [DOI] [PubMed] [Google Scholar]
  248. Peterson P. K., Lee D., Suh H. J., Devalon M., Nelson R. D., Keane W. F. Intracellular survival of Candida albicans in peritoneal macrophages from chronic peritoneal dialysis patients. Am J Kidney Dis. 1986 Feb;7(2):146–152. doi: 10.1016/s0272-6386(86)80136-6. [DOI] [PubMed] [Google Scholar]
  249. Piccolella E., Lombardi G., Morelli R. Generation of suppressor cells in the response of human lymphocytes to a polysaccharide from Candida albicans. J Immunol. 1981 Jun;126(6):2151–2155. [PubMed] [Google Scholar]
  250. Pittet D., Wenzel R. P. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med. 1995 Jun 12;155(11):1177–1184. doi: 10.1001/archinte.155.11.1177. [DOI] [PubMed] [Google Scholar]
  251. Podzorski R. P., Gray G. R., Nelson R. D. Different effects of native Candida albicans mannan and mannan-derived oligosaccharides on antigen-stimulated lymphoproliferation in vitro. J Immunol. 1990 Jan 15;144(2):707–716. [PubMed] [Google Scholar]
  252. Polak-Wyss A. Protective effect of human granulocyte colony stimulating factor (hG-CSF) on Candida infections in normal and immunosuppressed mice. Mycoses. 1991 Mar-Apr;34(3-4):109–118. doi: 10.1111/j.1439-0507.1991.tb00630.x. [DOI] [PubMed] [Google Scholar]
  253. Puccetti P., Mencacci A., Cenci E., Spaccapelo R., Mosci P., Enssle K. H., Romani L., Bistoni F. Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J Infect Dis. 1994 Jun;169(6):1325–1331. doi: 10.1093/infdis/169.6.1325. [DOI] [PubMed] [Google Scholar]
  254. Raponi G., Ghezzi M. C., Mancini C., Filadoro F. Culture filtrates and whole heat-killed Candida albicans stimulate human monocytes to release interleukin-6. New Microbiol. 1993 Jul;16(3):267–274. [PubMed] [Google Scholar]
  255. Raponi G., Ghezzi M. C., Mancini C., Filadoro F. Preincubation of Candida albicans strains with amphotericin B reduces tumor necrosis factor alpha and interleukin-6 release by human monocytes. Antimicrob Agents Chemother. 1993 Sep;37(9):1958–1961. doi: 10.1128/aac.37.9.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  256. Raptopoulou M., Goulis G. Physiological variations of T cells during the menstrual cycle. Clin Exp Immunol. 1977 Jun;28(3):458–460. [PMC free article] [PubMed] [Google Scholar]
  257. Ray T. L., Wuepper K. D. Activation of the alternative (properdin) pathway of complement by Candida albicans and related species. J Invest Dermatol. 1976 Dec;67(6):700–703. doi: 10.1111/1523-1747.ep12598581. [DOI] [PubMed] [Google Scholar]
  258. Ray T. L., Wuepper K. D. Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response. Arch Dermatol. 1978 Apr;114(4):539–543. doi: 10.1001/archderm.114.4.539. [DOI] [PubMed] [Google Scholar]
  259. Redmond H. P., Shou J., Gallagher H. J., Kelly C. J., Daly J. M. Macrophage-dependent candidacidal mechanisms in the murine system. Comparison of murine Kupffer cell and peritoneal macrophage candidacidal mechanisms. J Immunol. 1993 Apr 15;150(8 Pt 1):3427–3433. [PubMed] [Google Scholar]
  260. Rementería A., García-Tobalina R., Sevilla M. J. Nitric oxide-dependent killing of Candida albicans by murine peritoneal cells during an experimental infection. FEMS Immunol Med Microbiol. 1995 Jun;11(3):157–162. doi: 10.1111/j.1574-695X.1995.tb00112.x. [DOI] [PubMed] [Google Scholar]
  261. Richardson M. D., Brownlie C. E., Shankland G. S. Enhanced phagocytosis and intracellular killing of Candida albicans by GM-CSF-activated human neutrophils. J Med Vet Mycol. 1992;30(6):433–441. [PubMed] [Google Scholar]
  262. Richardson M. D., Smith H. Resistance of virulent and attenuated strains of Candida albicans to intracellular killing by human and mouse phagocytes. J Infect Dis. 1981 Dec;144(6):557–564. doi: 10.1093/infdis/144.6.557. [DOI] [PubMed] [Google Scholar]
  263. Rifkind D., Frey J. A. Influence of gonadectomy on Candida albicans urinary tract infection in CFW mice. Infect Immun. 1972 Mar;5(3):332–336. doi: 10.1128/iai.5.3.332-336.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  264. Rigg D., Miller M. M., Metzger W. J. Recurrent allergic vulvovaginitis: treatment with Candida albicans allergen immunotherapy. Am J Obstet Gynecol. 1990 Feb;162(2):332–336. doi: 10.1016/0002-9378(90)90380-p. [DOI] [PubMed] [Google Scholar]
  265. Riipi L., Carlson E. Tumor necrosis factor (TNF) is induced in mice by Candida albicans: role of TNF in fibrinogen increase. Infect Immun. 1990 Sep;58(9):2750–2754. doi: 10.1128/iai.58.9.2750-2754.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  266. Rivas V., Rogers T. J. Studies on the cellular nature of Candida albicans-induced suppression. J Immunol. 1983 Jan;130(1):376–379. [PubMed] [Google Scholar]
  267. Rogers T. J., Balish E., Manning D. D. The role of thymus-dependent cell-mediated immunity in resistance to experimental disseminated candidiasis. J Reticuloendothel Soc. 1976 Oct;20(4):291–298. [PubMed] [Google Scholar]
  268. Rogers T. J., Balish E. Suppression of lymphocyte blastogenesis by Candida albicans. Clin Immunol Immunopathol. 1978 Jul;10(3):298–305. doi: 10.1016/0090-1229(78)90185-x. [DOI] [PubMed] [Google Scholar]
  269. Roilides E., Holmes A., Blake C., Pizzo P. A., Walsh T. J. Effects of granulocyte colony-stimulating factor and interferon-gamma on antifungal activity of human polymorphonuclear neutrophils against pseudohyphae of different medically important Candida species. J Leukoc Biol. 1995 Apr;57(4):651–656. doi: 10.1002/jlb.57.4.651. [DOI] [PubMed] [Google Scholar]
  270. Roilides E., Uhlig K., Venzon D., Pizzo P. A., Walsh T. J. Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans: augmentation by granulocyte colony-stimulating factor and interferon-gamma. J Infect Dis. 1992 Sep;166(3):668–673. doi: 10.1093/infdis/166.3.668. [DOI] [PubMed] [Google Scholar]
  271. Roilides E., Walsh T. J., Pizzo P. A., Rubin M. Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis. 1991 Mar;163(3):579–583. doi: 10.1093/infdis/163.3.579. [DOI] [PubMed] [Google Scholar]
  272. Romagnani S. Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology. Int Arch Allergy Immunol. 1992;98(4):279–285. doi: 10.1159/000236199. [DOI] [PubMed] [Google Scholar]
  273. Romani L., Cenci E., Mencacci A., Spaccapelo R., Grohmann U., Puccetti P., Bistoni F. Gamma interferon modifies CD4+ subset expression in murine candidiasis. Infect Immun. 1992 Nov;60(11):4950–4952. doi: 10.1128/iai.60.11.4950-4952.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  274. Romani L., Mencacci A., Cenci E., Mosci P., Vitellozzi G., Grohmann U., Puccetti P., Bistoni F. Course of primary candidiasis in T cell-depleted mice infected with attenuated variant cells. J Infect Dis. 1992 Dec;166(6):1384–1392. doi: 10.1093/infdis/166.6.1384. [DOI] [PubMed] [Google Scholar]
  275. Romani L., Mencacci A., Cenci E., Spaccapelo R., Mosci P., Puccetti P., Bistoni F. CD4+ subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J Immunol. 1993 Feb 1;150(3):925–931. [PubMed] [Google Scholar]
  276. Romani L., Mencacci A., Cenci E., Spaccapelo R., Schiaffella E., Tonnetti L., Puccetti P., Bistoni F. Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice. Infect Immun. 1993 Sep;61(9):3769–3774. doi: 10.1128/iai.61.9.3769-3774.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  277. Romani L., Mencacci A., Grohmann U., Mocci S., Mosci P., Puccetti P., Bistoni F. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J Exp Med. 1992 Jul 1;176(1):19–25. doi: 10.1084/jem.176.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  278. Romani L., Mencacci A., Tonnetti L., Spaccapelo R., Cenci E., Puccetti P., Wolf S. F., Bistoni F. IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J Immunol. 1994 Dec 1;153(11):5167–5175. [PubMed] [Google Scholar]
  279. Romani L., Mencacci A., Tonnetti L., Spaccapelo R., Cenci E., Wolf S., Puccetti P., Bistoni F. Interleukin-12 but not interferon-gamma production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur J Immunol. 1994 Apr;24(4):909–915. doi: 10.1002/eji.1830240419. [DOI] [PubMed] [Google Scholar]
  280. Romani L., Mocci S., Bietta C., Lanfaloni L., Puccetti P., Bistoni F. Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect Immun. 1991 Dec;59(12):4647–4654. doi: 10.1128/iai.59.12.4647-4654.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  281. Romani L., Mocci S., Cenci E., Mencacci A., Sbaraglia G., Puccetti P., Bistoni F. Antigen-specific cytolysis of infected cells in murine candidiasis. Eur J Epidemiol. 1992 May;8(3):368–376. doi: 10.1007/BF00158570. [DOI] [PubMed] [Google Scholar]
  282. Romani L., Mocci S., Cenci E., Rossi R., Puccetti P., Bistoni F. Candida albicans-specific Ly-2+ lymphocytes with cytolytic activity. Eur J Immunol. 1991 Jun;21(6):1567–1570. doi: 10.1002/eji.1830210636. [DOI] [PubMed] [Google Scholar]
  283. Romani L., Puccetti P., Mencacci A., Cenci E., Spaccapelo R., Tonnetti L., Grohmann U., Bistoni F. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol. 1994 Apr 1;152(7):3514–3521. [PubMed] [Google Scholar]
  284. Romani L., Puccetti P., Mencacci A., Spaccapelo R., Cenci E., Tonnetti L., Bistoni F. Tolerance to staphylococcal enterotoxin B initiated Th1 cell differentiation in mice infected with Candida albicans. Infect Immun. 1994 Sep;62(9):4047–4053. doi: 10.1128/iai.62.9.4047-4053.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  285. Rosati E., Scaringi L., Cornacchione P., Fettucciari K., Sabatini R., Rossi R., Marconi P. Cytokine response to inactivated Candida albicans in mice. Cell Immunol. 1995 May;162(2):256–264. doi: 10.1006/cimm.1995.1077. [DOI] [PubMed] [Google Scholar]
  286. Rosenfeld S. I., Baum J., Steigbigel R. T., Leddy J. P. Hereditary deficiency of the fifth component of complement in man. II. Biological properties of C5-deficient human serum. J Clin Invest. 1976 Jun;57(6):1635–1643. doi: 10.1172/JCI108434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  287. Röcken M., Urban J. F., Shevach E. M. Infection breaks T-cell tolerance. Nature. 1992 Sep 3;359(6390):79–82. doi: 10.1038/359079a0. [DOI] [PubMed] [Google Scholar]
  288. SALVIN S. B., PETERSON R. D., GOOD R. A. THE ROLE OF THE THYMUS IN RESISTANCE TO INFECTION AND ENDOTOXIN TOXICITY. J Lab Clin Med. 1965 Jun;65:1004–1022. [PubMed] [Google Scholar]
  289. Salvin S. B., Neta R. Resistance and susceptibility to infection in inbred murine strains. I. Variations in the response to thymic hormones in mice infected with Candida albicans. Cell Immunol. 1983 Jan;75(1):160–172. doi: 10.1016/0008-8749(83)90315-5. [DOI] [PubMed] [Google Scholar]
  290. Salvin S. B., Tanner E. P. Resistance and susceptibility to infection in inbred murine strains. III. Effect of thymosin on cellular immune responses of alloxan diabetic mice. Clin Exp Immunol. 1984 Jan;55(1):133–139. [PMC free article] [PubMed] [Google Scholar]
  291. Sasada M., Kubo A., Nishimura T., Kakita T., Moriguchi T., Yamamoto K., Uchino H. Candidacidal activity of monocyte-derived human macrophages: relationship between Candida killing and oxygen radical generation by human macrophages. J Leukoc Biol. 1987 Apr;41(4):289–294. doi: 10.1002/jlb.41.4.289. [DOI] [PubMed] [Google Scholar]
  292. Sawyer R. T. Experimental pulmonary candidiasis. Mycopathologia. 1990 Feb;109(2):99–109. doi: 10.1007/BF00436790. [DOI] [PubMed] [Google Scholar]
  293. Sawyer R. T., Harmsen A. G. The relative contribution of resident pulmonary alveolar macrophage and inflammatory polymorphonuclear neutrophils in host resistance to pulmonary infection by Candida albicans. Mycopathologia. 1989 Nov;108(2):95–105. doi: 10.1007/BF00436059. [DOI] [PubMed] [Google Scholar]
  294. Scaringi L., Blasi E., Rosati E., Marconi P., Bistoni F. Fungicidal activity of Candida albicans-induced murine lymphokine-activated killer cells against C. albicans hyphae in vitro. J Gen Microbiol. 1991 Dec;137(12):2851–2856. doi: 10.1099/00221287-137-12-2851. [DOI] [PubMed] [Google Scholar]
  295. Scaringi L., Cornacchione P., Rosati E., Boccanera M., Cassone A., Bistoni F., Marconi P. Induction of LAK-like cells in the peritoneal cavity of mice by inactivated Candida albicans. Cell Immunol. 1990 Sep;129(2):271–287. doi: 10.1016/0008-8749(90)90204-5. [DOI] [PubMed] [Google Scholar]
  296. Scaringi L., Cornacchione P., Rosati E., Fettucciari K., Rossi R., Marconi P. Induction and persistence in vivo of NK/LAK activity by a mannoprotein component of Candida albicans cell wall. Cell Immunol. 1994 May;155(2):265–282. doi: 10.1006/cimm.1994.1121. [DOI] [PubMed] [Google Scholar]
  297. Scaringi L., Rosati E., Cornacchione P., Rossi R., Marconi P. In vivo modulation of lymphokine-activated killer cell activity by cell wall components of Candida albicans. Cell Immunol. 1992 Feb;139(2):438–454. doi: 10.1016/0008-8749(92)90084-3. [DOI] [PubMed] [Google Scholar]
  298. Schneider J., Vicandi J., Regulez P., Quindós G., Pontón J., Cisterna R. Different antibody response against Candida albicans cell wall antigens in cervicovaginal secretions of patients with vulvovaginal candidiasis. Gynecol Obstet Invest. 1990;30(3):174–177. doi: 10.1159/000293258. [DOI] [PubMed] [Google Scholar]
  299. Scott P., Natovitz P., Coffman R. L., Pearce E., Sher A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med. 1988 Nov 1;168(5):1675–1684. doi: 10.1084/jem.168.5.1675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  300. Shankar A. H., Titus R. G. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J Exp Med. 1995 Mar 1;181(3):845–855. doi: 10.1084/jem.181.3.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  301. Sieck T. G., Moors M. A., Buckley H. R., Blank K. J. Protection against murine disseminated candidiasis mediated by a Candida albicans-specific T-cell line. Infect Immun. 1993 Aug;61(8):3540–3543. doi: 10.1128/iai.61.8.3540-3543.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  302. Simark-Mattsson C., Bergenholtz G., Jontell M., Tarkowski A., Dahlgren U. I. T cell receptor V-gene usage in oral lichen planus; increased frequency of T cell receptors expressing V alpha 2 and V beta 3. Clin Exp Immunol. 1994 Dec;98(3):503–507. doi: 10.1111/j.1365-2249.1994.tb05519.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  303. Sinha B. K., Prasad S., Monga D. P. Studies of experimental candidiasis in T-cell-deficient mice. Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jun;265(1-2):203–209. doi: 10.1016/s0176-6724(87)80167-0. [DOI] [PubMed] [Google Scholar]
  304. Smith P. D., Lamerson C. L., Banks S. M., Saini S. S., Wahl L. M., Calderone R. A., Wahl S. M. Granulocyte-macrophage colony-stimulating factor augments human monocyte fungicidal activity for Candida albicans. J Infect Dis. 1990 May;161(5):999–1005. doi: 10.1093/infdis/161.5.999. [DOI] [PubMed] [Google Scholar]
  305. Sobel J. D. Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):924–935. doi: 10.1016/s0002-9378(85)80003-x. [DOI] [PubMed] [Google Scholar]
  306. Sohnle P. G., Collins-Lech C., Wiessner J. H. Antimicrobial activity of an abundant calcium-binding protein in the cytoplasm of human neutrophils. J Infect Dis. 1991 Jan;163(1):187–192. doi: 10.1093/infdis/163.1.187. [DOI] [PubMed] [Google Scholar]
  307. Solomkin J. S., Mills E. L., Giebink G. S., Nelson R. D., Simmons R. L., Quie P. G. Phagocytosis of Candida albicans by human leukocytes: opsonic requirements. J Infect Dis. 1978 Jan;137(1):30–37. doi: 10.1093/infdis/137.1.30. [DOI] [PubMed] [Google Scholar]
  308. Sordelli D. O., Cassino R. J., Macri C. N., Kohan M., Dillon M. H., Pivetta O. H. Phagocytosis of Candida albicans by alveolar macrophages from patients with cystic fibrosis. Clin Immunol Immunopathol. 1982 Feb;22(2):153–158. doi: 10.1016/0090-1229(82)90033-2. [DOI] [PubMed] [Google Scholar]
  309. Spaccapelo R., Romani L., Tonnetti L., Cenci E., Mencacci A., Del Sero G., Tognellini R., Reed S. G., Puccetti P., Bistoni F. TGF-beta is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans. J Immunol. 1995 Aug 1;155(3):1349–1360. [PubMed] [Google Scholar]
  310. Stein D. K., Malawista S. E., Van Blaricom G., Wysong D., Diamond R. D. Cytoplasts generate oxidants but require added neutrophil granule constituents for fungicidal activity against Candida albicans hyphae. J Infect Dis. 1995 Aug;172(2):511–520. doi: 10.1093/infdis/172.2.511. [DOI] [PubMed] [Google Scholar]
  311. Steinbakk M., Naess-Andresen C. F., Lingaas E., Dale I., Brandtzaeg P., Fagerhol M. K. Antimicrobial actions of calcium binding leucocyte L1 protein, calprotectin. Lancet. 1990 Sep 29;336(8718):763–765. doi: 10.1016/0140-6736(90)93237-j. [DOI] [PubMed] [Google Scholar]
  312. Steinshamn S., Bergh K., Waage A. Effects of stem cell factor and granulocyte colony-stimulating factor on granulocyte recovery and Candida albicans infection in granulocytopenic mice. J Infect Dis. 1993 Dec;168(6):1444–1448. doi: 10.1093/infdis/168.6.1444. [DOI] [PubMed] [Google Scholar]
  313. Steinshamn S., Waage A. Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice. Infect Immun. 1992 Oct;60(10):4003–4008. doi: 10.1128/iai.60.10.4003-4008.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  314. Stevenhagen A., van Furth R. Interferon-gamma activates the oxidative killing of Candida albicans by human granulocytes. Clin Exp Immunol. 1993 Jan;91(1):170–175. doi: 10.1111/j.1365-2249.1993.tb03374.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  315. Stobo J. D., Paul S., Van Scoy R. E., Hermans P. E. Suppressor thymus-derived lymphocytes in fungal infection. J Clin Invest. 1976 Feb;57(2):319–328. doi: 10.1172/JCI108283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  316. Sundstrom P., Jensen J., Balish E. Humoral and cellular immune responses to enolase after alimentary tract colonization or intravenous immunization with Candida albicans. J Infect Dis. 1994 Aug;170(2):390–395. doi: 10.1093/infdis/170.2.390. [DOI] [PubMed] [Google Scholar]
  317. Syverson R. E., Buckley H., Gibian J., Ryan G. M., Jr Cellular and humoral immune status in women with chronic Candida vaginitis. Am J Obstet Gynecol. 1979 Jul 15;134(6):624–627. doi: 10.1016/0002-9378(79)90641-0. [DOI] [PubMed] [Google Scholar]
  318. Szabo P., Weksler M. E. Is thymosin alpha 1 a thymic hormone? Clin Immunol Immunopathol. 1992 Dec;65(3):195–200. doi: 10.1016/0090-1229(92)90146-f. [DOI] [PubMed] [Google Scholar]
  319. Tavares D., Ferreira P., Vilanova M., Videira A., Arala-Chaves M. Immunoprotection against systemic candidiasis in mice. Int Immunol. 1995 May;7(5):785–796. doi: 10.1093/intimm/7.5.785. [DOI] [PubMed] [Google Scholar]
  320. Tavares D., Salvador A., Ferreira P., Arala-Chaves M. Immunological activities of a Candida albicans protein which plays an important role in the survival of the microorganism in the host. Infect Immun. 1993 May;61(5):1881–1888. doi: 10.1128/iai.61.5.1881-1888.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  321. Thompson H. L., Wilton J. M. Interaction and intracellular killing of Candida albicans blastospores by human polymorphonuclear leucocytes, monocytes and monocyte-derived macrophages in aerobic and anaerobic conditions. Clin Exp Immunol. 1992 Feb;87(2):316–321. doi: 10.1111/j.1365-2249.1992.tb02994.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  322. Tonnetti L., Spaccapelo R., Cenci E., Mencacci A., Puccetti P., Coffman R. L., Bistoni F., Romani L. Interleukin-4 and -10 exacerbate candidiasis in mice. Eur J Immunol. 1995 Jun;25(6):1559–1565. doi: 10.1002/eji.1830250614. [DOI] [PubMed] [Google Scholar]
  323. Torosantucci A., Bromuro C., Gomez M. J., Ausiello C. M., Urbani F., Cassone A. Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune response to Candida albicans. J Infect Dis. 1993 Aug;168(2):427–435. doi: 10.1093/infdis/168.2.427. [DOI] [PubMed] [Google Scholar]
  324. Torosantucci A., Palma C., Boccanera M., Ausiello C. M., Spagnoli G. C., Cassone A. Lymphoproliferative and cytotoxic responses of human peripheral blood mononuclear cells to mannoprotein constituents of Candida albicans. J Gen Microbiol. 1990 Nov;136(11):2155–2163. doi: 10.1099/00221287-136-11-2155. [DOI] [PubMed] [Google Scholar]
  325. Treseler C. B., Maziarz R. T., Levitz S. M. Biological activity of interleukin-2 bound to Candida albicans. Infect Immun. 1992 Jan;60(1):183–188. doi: 10.1128/iai.60.1.183-188.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  326. Uchida K., Yamamoto Y., Klein T. W., Friedman H., Yamaguchi H. Granulocyte-colony stimulating factor facilitates the restoration of resistance to opportunistic fungi in leukopenic mice. J Med Vet Mycol. 1992;30(4):293–300. doi: 10.1080/02681219280000381. [DOI] [PubMed] [Google Scholar]
  327. Valdez J. C., Mesón O. E., Sirena A., de Alderete N. G. Characteristics of DTH suppressor cells in mice infected with Candida albicans. Mycopathologia. 1987 May;98(2):121–126. doi: 10.1007/BF00437298. [DOI] [PubMed] [Google Scholar]
  328. Vazquez-Torres A., Jones-Carson J., Balish E. Candidacidal activity of macrophages from immunocompetent and congenitally immunodeficient mice. J Infect Dis. 1994 Jul;170(1):180–188. doi: 10.1093/infdis/170.1.180. [DOI] [PubMed] [Google Scholar]
  329. Vazquez-Torres A., Jones-Carson J., Balish E. Nitric oxide production does not directly increase macrophage candidacidal activity. Infect Immun. 1995 Mar;63(3):1142–1144. doi: 10.1128/iai.63.3.1142-1144.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  330. Vazquez-Torres A., Jones-Carson J., Warner T., Balish E. Nitric oxide enhances resistance of SCID mice to mucosal candidiasis. J Infect Dis. 1995 Jul;172(1):192–198. doi: 10.1093/infdis/172.1.192. [DOI] [PubMed] [Google Scholar]
  331. Vecchiarelli A., Cenci E., Puliti M., Blasi E., Puccetti P., Cassone A., Bistoni F. Protective immunity induced by low-virulence Candida albicans: cytokine production in the development of the anti-infectious state. Cell Immunol. 1989 Dec;124(2):334–344. doi: 10.1016/0008-8749(89)90135-4. [DOI] [PubMed] [Google Scholar]
  332. Vecchiarelli A., Dottorini M., Cociani C., Pietrella D., Todisco T., Bistoni F. Mechanism of intracellular candidacidal activity mediated by calcium ionophore in human alveolar macrophages. Am J Respir Cell Mol Biol. 1993 Jul;9(1):19–25. doi: 10.1165/ajrcmb/9.1.19. [DOI] [PubMed] [Google Scholar]
  333. Vecchiarelli A., Mazzolla R., Farinelli S., Cassone A., Bistoni F. Immunomodulation by Candida albicans: crucial role of organ colonization and chronic infection with an attenuated agerminative strain of C. albicans for establishment of anti-infectious protection. J Gen Microbiol. 1988 Sep;134(9):2583–2592. doi: 10.1099/00221287-134-9-2583. [DOI] [PubMed] [Google Scholar]
  334. Vecchiarelli A., Monari C., Baldelli F., Pietrella D., Retini C., Tascini C., Francisci D., Bistoni F. Beneficial effect of recombinant human granulocyte colony-stimulating factor on fungicidal activity of polymorphonuclear leukocytes from patients with AIDS. J Infect Dis. 1995 Jun;171(6):1448–1454. doi: 10.1093/infdis/171.6.1448. [DOI] [PubMed] [Google Scholar]
  335. Vecchiarelli A., Todisco T., Puliti M., Dottorini M., Bistoni F. Modulation of anti-Candida activity of human alveolar macrophages by interferon-gamma or interleukin-1-alpha. Am J Respir Cell Mol Biol. 1989 Jul;1(1):49–55. doi: 10.1165/ajrcmb/1.1.49. [DOI] [PubMed] [Google Scholar]
  336. Walker K. B., Butler R., Colston M. J. Role of Th-1 lymphocytes in the development of protective immunity against Mycobacterium leprae. Analysis of lymphocyte function by polymerase chain reaction detection of cytokine messenger RNA. J Immunol. 1992 Mar 15;148(6):1885–1889. [PubMed] [Google Scholar]
  337. Walsh T. J., Hathorn J. W., Sobel J. D., Merz W. G., Sanchez V., Maret S. M., Buckley H. R., Pfaller M. A., Schaufele R., Sliva C. Detection of circulating candida enolase by immunoassay in patients with cancer and invasive candidiasis. N Engl J Med. 1991 Apr 11;324(15):1026–1031. doi: 10.1056/NEJM199104113241504. [DOI] [PubMed] [Google Scholar]
  338. Wang M., Friedman H., Djeu J. Y. Enhancement of human monocyte function against Candida albicans by the colony-stimulating factors (CSF): IL-3, granulocyte-macrophage-CSF, and macrophage-CSF. J Immunol. 1989 Jul 15;143(2):671–677. [PubMed] [Google Scholar]
  339. Watanabe K., Kagaya K., Yamada T., Fukazawa Y. Mechanism for candidacidal activity in macrophages activated by recombinant gamma interferon. Infect Immun. 1991 Feb;59(2):521–528. doi: 10.1128/iai.59.2.521-528.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  340. Wei S., Blanchard D. K., Liu J. H., Leonard W. J., Djeu J. Y. Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta. J Immunol. 1993 Mar 1;150(5):1979–1987. [PubMed] [Google Scholar]
  341. Wei S., Blanchard D. K., McMillen S., Djeu J. Y. Lymphokine-activated killer cell regulation of T-cell-mediated immunity to Candida albicans. Infect Immun. 1992 Sep;60(9):3586–3595. doi: 10.1128/iai.60.9.3586-3595.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  342. Wei S., Serbousek D., McMillen S., Blanchard D. K., Djeu J. Y. Suppression of human monocyte function against Candida albicans by autologous IL-2-induced lymphokine-activated killer cells. J Immunol. 1991 Jan 1;146(1):337–342. [PubMed] [Google Scholar]
  343. Wey S. B., Mori M., Pfaller M. A., Woolson R. F., Wenzel R. P. Hospital-acquired candidemia. The attributable mortality and excess length of stay. Arch Intern Med. 1988 Dec;148(12):2642–2645. doi: 10.1001/archinte.148.12.2642. [DOI] [PubMed] [Google Scholar]
  344. White J., Herman A., Pullen A. M., Kubo R., Kappler J. W., Marrack P. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 1989 Jan 13;56(1):27–35. doi: 10.1016/0092-8674(89)90980-x. [DOI] [PubMed] [Google Scholar]
  345. Wilson B. D., Sohnle P. G. Neutrophil accumulation and cutaneous responses in experimental cutaneous candidiasis of genetically complement-deficient mice. Clin Immunol Immunopathol. 1988 Feb;46(2):284–293. doi: 10.1016/0090-1229(88)90190-0. [DOI] [PubMed] [Google Scholar]
  346. Witkin S. S., Hirsch J., Ledger W. J. A macrophage defect in women with recurrent Candida vaginitis and its reversal in vitro by prostaglandin inhibitors. Am J Obstet Gynecol. 1986 Oct;155(4):790–795. doi: 10.1016/s0002-9378(86)80022-9. [DOI] [PubMed] [Google Scholar]
  347. Witkin S. S. Inhibition of Candida-induced lymphocyte proliferation by antibody to Candida albicans. Obstet Gynecol. 1986 Nov;68(5):696–699. [PubMed] [Google Scholar]
  348. Witkin S. S., Jeremias J., Ledger W. J. A localized vaginal allergic response in women with recurrent vaginitis. J Allergy Clin Immunol. 1988 Feb;81(2):412–416. doi: 10.1016/0091-6749(88)90909-8. [DOI] [PubMed] [Google Scholar]
  349. Witkin S. S., Yu I. R., Ledger W. J. Inhibition of Candida albicans--induced lymphocyte proliferation by lymphocytes and sera from women with recurrent vaginitis. Am J Obstet Gynecol. 1983 Dec 1;147(7):809–811. doi: 10.1016/0002-9378(83)90044-3. [DOI] [PubMed] [Google Scholar]
  350. Yamamoto Y., Klein T. W., Friedman H., Kimura S., Yamaguchi H. Granulocyte colony-stimulating factor potentiates anti-Candida albicans growth inhibitory activity of polymorphonuclear cells. FEMS Immunol Med Microbiol. 1993 Jun;7(1):15–22. doi: 10.1111/j.1574-695X.1993.tb00376.x. [DOI] [PubMed] [Google Scholar]
  351. Yamamura M., Valdimarsson H. Participation of C3 in intracellular killing of Candida albicans. Scand J Immunol. 1977;6(6-7):591–594. doi: 10.1111/j.1365-3083.1977.tb02137.x. [DOI] [PubMed] [Google Scholar]
  352. Zinkernagel R. M., Blanden R. V. Macrophage activation in mice lacking thymus-derived (T) cells. Experientia. 1975 May 15;31(5):591–593. doi: 10.1007/BF01932477. [DOI] [PubMed] [Google Scholar]
  353. Zinkernagel R. M., Pfau C. J., Hengartner H., Althage A. Susceptibility to murine lymphocytic choriomeningitis maps to class I MHC genes--a model for MHC/disease associations. 1985 Aug 29-Sep 4Nature. 316(6031):814–817. doi: 10.1038/316814a0. [DOI] [PubMed] [Google Scholar]
  354. Zouali M., Drouhet E., Eyquem A. Evaluation of auto-antibodies in chronic mucocutaneous candidiasis without endocrinopathy. Mycopathologia. 1984 Feb 15;84(2-3):87–93. doi: 10.1007/BF00436518. [DOI] [PubMed] [Google Scholar]
  355. Zunino S. J., Hudig D. Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans, although C. albicans blocks NK lysis of K562 cells. Infect Immun. 1988 Mar;56(3):564–569. doi: 10.1128/iai.56.3.564-569.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  356. de Boer J. P., Wolbink G. J., Thijs L. G., Baars J. W., Wagstaff J., Hack C. E. Interplay of complement and cytokines in the pathogenesis of septic shock. Immunopharmacology. 1992 Sep-Oct;24(2):135–148. doi: 10.1016/0162-3109(92)90019-9. [DOI] [PubMed] [Google Scholar]
  357. di Francesco P., Gaziano R., Casalinuovo I. A., Belogi L., Palamara A. T., Favalli C., Garaci E. Combined effect of fluconazole and thymosin alpha 1 on systemic candidiasis in mice immunosuppressed by morphine treatments. Clin Exp Immunol. 1994 Sep;97(3):347–352. doi: 10.1111/j.1365-2249.1994.tb06093.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  358. van 't Wout J. W., Linde I., Leijh P. C., van Furth R. Contribution of granulocytes and monocytes to resistance against experimental disseminated Candida albicans infection. Eur J Clin Microbiol Infect Dis. 1988 Dec;7(6):736–741. doi: 10.1007/BF01975039. [DOI] [PubMed] [Google Scholar]
  359. van 't Wout J. W., Poell R., van Furth R. The role of BCG/PPD-activated macrophages in resistance against systemic candidiasis in mice. Scand J Immunol. 1992 Nov;36(5):713–719. doi: 10.1111/j.1365-3083.1992.tb03132.x. [DOI] [PubMed] [Google Scholar]

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