Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures

Abstract

Correction to: British Journal of Cancer (2003) 88, 613–623; doi:10.1038/sj.bjc.66000681

Reference on p. 614 and in Table 2 (p. 615) to human recombinant arginine decarboxylase is incorrect, as elsewhere in the article. The enzyme was prepared by the overexpression of biosynthetic arginine decarboxylase (speA), originating in Escherichia coli and purified from E. coli TOP 10 as a fusion protein (5xHis::speA) on a nickel-affinity column (Invitrogen).

We wish to apologise to Professor Stephen Boyle (Virginia Polytechnic Institute & State University, Blackburg, VA, USA), who kindly provided the enzyme for Cancer Treatments International, for this regrettable mistake.

DN Wheatley