Abstract
Purpose. This paper describes the clinical history and radiographic appearance of second malignancies in patients with bilateral retinoblastoma.
Subjects/methods. The imaging studies and clinical data of 14 patients with a history of bilateral retinoblastoma who were treated for second malignancies were reviewed.
Results. A total of 17 tumors were identified in 14 patients during the period 1978–1996. The median age of occurrence of the second malignancy was 17 years (range 10–32 years). Fourteen of the 17 malignancies occurred in the facial structures and three developed in the lower extremities. The histologies included osteosarcoma (n = 5), malignant fibrous histiocytoma (n = 3), high-grade spindle cell sarcoma (n = 3), malignant mesenchymoma (n = 1), leiomyosarcoma (n = 4) and angiosarcoma (n = 1). The tumors were locally aggressive and had a similar appearance to those found in nonretinoblastoma patients. Six of the 14 patients are alive and disease free.
Discussion. Most of the adolescent and young adult retinoblastoma survivors developed second malignancies in the irradiated facial structures but some occurred in distal sites. Radiologically, these tumors do not differ in appearance from those seen in non-retinoblastoma patients with the exception of their location.
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Selected References
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- Abramson D. H., Ellsworth R. M., Kitchin F. D., Tung G. Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? Ophthalmology. 1984 Nov;91(11):1351–1355. doi: 10.1016/s0161-6420(84)34127-6. [DOI] [PubMed] [Google Scholar]
- Abramson D. H., Ellsworth R. M. The surgical management of retinoblastoma. Ophthalmic Surg. 1980 Sep;11(9):596–598. [PubMed] [Google Scholar]
- Eng C., Li F. P., Abramson D. H., Ellsworth R. M., Wong F. L., Goldman M. B., Seddon J., Tarbell N., Boice J. D., Jr Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst. 1993 Jul 21;85(14):1121–1128. doi: 10.1093/jnci/85.14.1121. [DOI] [PubMed] [Google Scholar]
- Hansen M. F., Koufos A., Gallie B. L., Phillips R. A., Fodstad O., Brøgger A., Gedde-Dahl T., Cavenee W. K. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6216–6220. doi: 10.1073/pnas.82.18.6216. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hawkins M. M., Draper G. J., Kingston J. E. Incidence of second primary tumours among childhood cancer survivors. Br J Cancer. 1987 Sep;56(3):339–347. doi: 10.1038/bjc.1987.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kim J. H., Chu F. C., Woodward H. Q., Huvos A. Radiation induced sarcomas of bone following therapeutic radiation. Int J Radiat Oncol Biol Phys. 1983 Jan;9(1):107–110. doi: 10.1016/0360-3016(83)90218-3. [DOI] [PubMed] [Google Scholar]
- Kingston J. E., Hawkins M. M., Draper G. J., Marsden H. B., Kinnier Wilson L. M. Patterns of multiple primary tumours in patients treated for cancer during childhood. Br J Cancer. 1987 Sep;56(3):331–338. doi: 10.1038/bjc.1987.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Knudson A. G., Jr, Meadows A. T., Nichols W. W., Hill R. Chromosomal deletion and retinoblastoma. N Engl J Med. 1976 Nov 11;295(20):1120–1123. doi: 10.1056/NEJM197611112952007. [DOI] [PubMed] [Google Scholar]
- LELE K. P., PENROSE L. S., STALLARD H. B. CHROMOSOME DELETION IN A CASE OF RETINOBLASTOMA. Ann Hum Genet. 1963 Nov;27:171–174. doi: 10.1111/j.1469-1809.1963.tb00209.x. [DOI] [PubMed] [Google Scholar]
- Sagerman R. H., Cassady J. R., Tretter P., Ellsworth R. M. Radiation induced neoplasia following external beam therapy for children with retinoblastoma. Am J Roentgenol Radium Ther Nucl Med. 1969 Mar;105(3):529–535. doi: 10.2214/ajr.105.3.529. [DOI] [PubMed] [Google Scholar]
- Yunis J. J., Ramsay N. Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child. 1978 Feb;132(2):161–163. doi: 10.1001/archpedi.1978.02120270059012. [DOI] [PubMed] [Google Scholar]