Skip to main content
PMC home page
Sarcoma logoLink to Sarcoma
. 1997 Jun;1(2):109–111. doi: 10.1080/13577149778399

Disseminating Adamantinoma of the Tibia

Albert N Van Geel 1,2,✉, Hans M Hazelbag 3, Rob Slingerland 4, Margit I Vermeulen 1
PMCID: PMC2395358  PMID: 18521211

Abstract

Patient. This report describes a patient with a primary long bone adamantinoma. The lesion was initially wrongly diagnosed as fibrous dysplasia and the patient was treated by curettage. At second local recurrence, the tumour had progressed from an osteofibrous dysplasia-like to a full-blown classic adamantinoma, with metastatic potential to the lungs 19 years after the initial treatment. Lung metastasectomy by sternotomy was carried out twice in a period of over 3.5 years. The patient is currently alive without evidence of other metastatic disease.

Discussion. From the files of the Netherlands Committee on Bone Tumors, another five patients with lung metastaseswere studied. All types of adamantinoma should be treated by complete en bloc resection. For patients with metastatic spread to the lungs, close radiological follow-up and excision of tumour nodules seems to be the only logic treatment modality.

Full Text

The Full Text of this article is available as a PDF (97.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bambirra E. A., Nogueira A. M., Miranda D. Adamantinoma of the soft tissue of the leg. Arch Pathol Lab Med. 1983 Sep;107(9):500–501. [PubMed] [Google Scholar]
  2. Bloem J. L., van der Heul R. O., Schuttevaer H. M., Kuipers D. Fibrous dysplasia vs adamantinoma of the tibia: differentiation based on discriminant analysis of clinical and plain film findings. AJR Am J Roentgenol. 1991 May;156(5):1017–1023. doi: 10.2214/ajr.156.5.2017924. [DOI] [PubMed] [Google Scholar]
  3. Cohn B. T., Brahms M. A., Froimson A. I. Metastasis of adamantinoma sixteen years after knee disarticulation. Report of a case. J Bone Joint Surg Am. 1986 Jun;68(5):772–776. [PubMed] [Google Scholar]
  4. Czerniak B., Rojas-Corona R. R., Dorfman H. D. Morphologic diversity of long bone adamantinoma. The concept of differentiated (regressing) adamantinoma and its relationship to osteofibrous dysplasia. Cancer. 1989 Dec 1;64(11):2319–2334. doi: 10.1002/1097-0142(19891201)64:11<2319::aid-cncr2820641123>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  5. Hazelbag H. M., Fleuren G. J., Cornelisse C. J., van den Broek L. J., Taminiau A. H., Hogendoorn P. C. DNA aberrations in the epithelial cell component of adamantinoma of long bones. Am J Pathol. 1995 Dec;147(6):1770–1779. [PMC free article] [PubMed] [Google Scholar]
  6. Hazelbag H. M., Taminiau A. H., Fleuren G. J., Hogendoorn P. C. Adamantinoma of the long bones. A clinicopathological study of thirty-two patients with emphasis on histological subtype, precursor lesion, and biological behavior. J Bone Joint Surg Am. 1994 Oct;76(10):1482–1499. doi: 10.2106/00004623-199410000-00008. [DOI] [PubMed] [Google Scholar]
  7. Hazelbag H. M., Van den Broek L. J., Fleuren G. J., Taminiau A. H., Hogendoorn P. C. Distribution of extracellular matrix components in adamantinoma of long bones suggests fibrous-to-epithelial transformation. Hum Pathol. 1997 Feb;28(2):183–188. doi: 10.1016/s0046-8177(97)90104-0. [DOI] [PubMed] [Google Scholar]
  8. Keeney G. L., Unni K. K., Beabout J. W., Pritchard D. J. Adamantinoma of long bones. A clinicopathologic study of 85 cases. Cancer. 1989 Aug 1;64(3):730–737. doi: 10.1002/1097-0142(19890801)64:3<730::aid-cncr2820640327>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  9. Knapp R. H., Wick M. R., Scheithauer B. W., Unni K. K. Adamantinoma of bone. An electron microscopic and immunohistochemical study. Virchows Arch A Pathol Anat Histopathol. 1982;398(1):75–86. doi: 10.1007/BF00585615. [DOI] [PubMed] [Google Scholar]
  10. Lokich J. Metastatic adamantinoma of bone to lung. A case report of the natural history and the use of chemotherapy and radiation therapy. Am J Clin Oncol. 1994 Apr;17(2):157–159. [PubMed] [Google Scholar]
  11. Mills S. E., Rosai J. Adamantinoma of the pretibial soft tissue. Clinicopathologic features, differential diagnosis, and possible relationship to intraosseous disease. Am J Clin Pathol. 1985 Jan;83(1):108–114. doi: 10.1093/ajcp/83.1.108. [DOI] [PubMed] [Google Scholar]
  12. Moon N. F. Adamantinoma of the appendicular skeleton in children. Int Orthop. 1994;18(6):379–388. doi: 10.1007/BF00187087. [DOI] [PubMed] [Google Scholar]
  13. Moon N. F., Mori H. Adamantinoma of the appendicular skeleton--updated. Clin Orthop Relat Res. 1986 Mar;(204):215–237. [PubMed] [Google Scholar]
  14. Pastorino U., Buyse M., Friedel G., Ginsberg R. J., Girard P., Goldstraw P., Johnston M., McCormack P., Pass H., Putnam J. B., Jr Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 1997 Jan;113(1):37–49. doi: 10.1016/s0022-5223(97)70397-0. [DOI] [PubMed] [Google Scholar]
  15. Perez-Atayde A. R., Kozakewich H. P., Vawter G. F. Adamantinoma of the tibia. An ultrastructural and immunohistochemical study. Cancer. 1985 Mar 1;55(5):1015–1023. doi: 10.1002/1097-0142(19850301)55:5<1015::aid-cncr2820550516>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  16. Rosai J. Adamantinoma of the tibia. Electron microscopic evidence of its epithelial origin. Am J Clin Pathol. 1969 Jun;51(6):786–792. doi: 10.1093/ajcp/51.6.786. [DOI] [PubMed] [Google Scholar]
  17. Rosai J., Pinkus G. S. Immunohistochemical demonstration of epithelial differentiation in adamantinoma of the tibia. Am J Surg Pathol. 1982 Jul;6(5):427–434. doi: 10.1097/00000478-198207000-00004. [DOI] [PubMed] [Google Scholar]
  18. Springfield D. S., Rosenberg A. E., Mankin H. J., Mindell E. R. Relationship between osteofibrous dysplasia and adamantinoma. Clin Orthop Relat Res. 1994 Dec;(309):234–244. [PubMed] [Google Scholar]
  19. Van Schoor J. X., Vallaeys J. H., Joos G. F., Roels H. J., Pauwels R. A., Van Der Straeten M. E. Adamantinoma of the tibia with pulmonary metastases and hypercalcemia. Chest. 1991 Jul;100(1):279–281. doi: 10.1378/chest.100.1.279. [DOI] [PubMed] [Google Scholar]

Articles from Sarcoma are provided here courtesy of Wiley

RESOURCES