Abstract
Purpose: Periosteal osteosarcomas are rare cartilage-rich bone tumours characterized by a juxtacortical eccentric position and are normally regarded oncologically as of intermediate to high grade.Their low incidence is mirrored by a small number of reported cases in the world literature. While there is general agreement that wide surgical excision is required, there is a paucity of evidence regarding adjuvant therapy. Previous reports have not indicated any consistent approach to this to allow appraisal.
Patients and methods: We report 17 cases treated at our centre over 16 years. Our policy was to use chemotherapy when the tumour showed any features of high grade.
Results: To date, no deaths have resulted from recurrence or metastasis of the tumour although there have been two deaths from other causes.
Discussion: Comparison of survival with existing studies is made to draw conclusions regarding future treatment of this condition in terms of surgical and adjuvant approaches.
Full Text
The Full Text of this article is available as a PDF (598.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bertoni F., Boriani S., Laus M., Campanacci M. Periosteal chondrosarcoma and periosteal osteosarcoma. Two distinct entities. J Bone Joint Surg Br. 1982;64(3):370–376. doi: 10.1302/0301-620X.64B3.7096408. [DOI] [PubMed] [Google Scholar]
- Bramwell V. H., Burgers M., Sneath R., Souhami R., van Oosterom A. T., Voûte P. A., Rouesse J., Spooner D., Craft A. W., Somers R. A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup. J Clin Oncol. 1992 Oct;10(10):1579–1591. doi: 10.1200/JCO.1992.10.10.1579. [DOI] [PubMed] [Google Scholar]
- Campanacci M., Giunti A. Periosteal osteosarcoma. Review of 41 cases, 22 with long-term follow-up. Ital J Orthop Traumatol. 1976 Apr;2(1):23–35. [PubMed] [Google Scholar]
- Enneking W. F. A system of staging musculoskeletal neoplasms. Clin Orthop Relat Res. 1986 Mar;(204):9–24. [PubMed] [Google Scholar]
- Grimer R. J., Carter S. R., Tillman R. M., Sneath R. S., Walker P. S., Unwin P. S., Shewell P. C. Endoprosthetic replacement of the proximal tibia. J Bone Joint Surg Br. 1999 May;81(3):488–494. doi: 10.1302/0301-620x.81b3.9234. [DOI] [PubMed] [Google Scholar]
- Hall R. B., Robinson L. H., Malawar M. M., Dunham W. K. Periosteal osteosarcoma. Cancer. 1985 Jan 1;55(1):165–171. doi: 10.1002/1097-0142(19850101)55:1<165::aid-cncr2820550126>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Kabukcuoglu Y., Grimer R. J., Tillman R. M., Carter S. R. Endoprosthetic replacement for primary malignant tumors of the proximal femur. Clin Orthop Relat Res. 1999 Jan;(358):8–14. [PubMed] [Google Scholar]
- Kleihues P., Schäuble B., zur Hausen A., Estève J., Ohgaki H. Tumors associated with p53 germline mutations: a synopsis of 91 families. Am J Pathol. 1997 Jan;150(1):1–13. [PMC free article] [PubMed] [Google Scholar]
- LICHTENSTEIN L. Tumors of periosteal origin. Cancer. 1955 Sep-Oct;8(5):1060–1069. doi: 10.1002/1097-0142(1955)8:5<1060::aid-cncr2820080533>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Masterson E. L., Ferracini R., Davis A. M., Wunder J. S., Bell R. S. The geometric osteotomy: joint preservation in juxta-articular surface bone neoplasms. Sarcoma. 1997;1(3-4):167–174. doi: 10.1080/13577149778263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meister P., Konrad E., Lob G., Janka G., Keyl W., Stürz H. Osteosarcoma: histological evaluation and grading. Arch Orthop Trauma Surg. 1979 Jul 31;94(2):91–98. doi: 10.1007/BF00433573. [DOI] [PubMed] [Google Scholar]
- Ritts G. D., Pritchard D. J., Unni K. K., Beabout J. W., Eckardt J. J. Periosteal osteosarcoma. Clin Orthop Relat Res. 1987 Jun;(219):299–307. [PubMed] [Google Scholar]
- Roberts P., Chan D., Grimer R. J., Sneath R. S., Scales J. T. Prosthetic replacement of the distal femur for primary bone tumours. J Bone Joint Surg Br. 1991 Sep;73(5):762–769. doi: 10.1302/0301-620X.73B5.1894662. [DOI] [PubMed] [Google Scholar]
- Souhami R. L., Craft A. W., Van der Eijken J. W., Nooij M., Spooner D., Bramwell V. H., Wierzbicki R., Malcolm A. J., Kirkpatrick A., Uscinska B. M. Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. Lancet. 1997 Sep 27;350(9082):911–917. doi: 10.1016/S0140-6736(97)02307-6. [DOI] [PubMed] [Google Scholar]
- Unni K. K., Dahlin D. C., Beabout J. W. Periosteal osteogenic sarcoma. Cancer. 1976 May;37(5):2476–2485. doi: 10.1002/1097-0142(197605)37:5<2476::aid-cncr2820370541>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
- Unni K. K., Dahlin D. C. Grading of bone tumors. Semin Diagn Pathol. 1984 Aug;1(3):165–172. [PubMed] [Google Scholar]
- Unwin P. S., Cannon S. R., Grimer R. J., Kemp H. B., Sneath R. S., Walker P. S. Aseptic loosening in cemented custom-made prosthetic replacements for bone tumours of the lower limb. J Bone Joint Surg Br. 1996 Jan;78(1):5–13. [PubMed] [Google Scholar]
- Weeden S., Grimer R. J., Cannon S. R., Taminiau A. H., Uscinska B. M., European Osteosarcoma Intergroup The effect of local recurrence on survival in resected osteosarcoma. Eur J Cancer. 2001 Jan;37(1):39–46. doi: 10.1016/s0959-8049(00)00362-2. [DOI] [PubMed] [Google Scholar]