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. 2003 Sep-Dec;7(3-4):149–152. doi: 10.1080/13577140310001644760

Treatment of Epithelioid Sarcoma at the Royal Marsden Hospital

L Livi 1,4,✉, N Shah 2, F Paiar 1, C Fisher 3, I Judson 3, E Moskovic 3, M Thomas 3, C Harmer 3
PMCID: PMC2395532  PMID: 18521379

Abstract

Purpose: The aim of this study was to assess treatment and outcome with respect to clinical and pathological features.

Patients and methods: Thirty-nine patients were identified (range 7–66 years, mean 23). Initial treatment comprised local excision in 11 patients and wide excision in 14. Post-operative external beam radiotherapy was prescribed in 22 patients with a total dose of 60 Gy, delivered in two phases.

Results: The cause-specific survival for the entire group was 79, 63, 56 and 45% at 1, 3, 5 and 10 years, respectively. A distal limb location was associated with a better prognosis than proximal limb location (P = 0.04).

Conclusions: Our data favour treatment with wide functional excision followed by radical dose radiotherapy in attempt to minimize risk of local recurrence, especially when primary tumours are bigger than 3 cm. Our data also suggest the same treatment for local recurrence, when technically possible, to avoid amputation.

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Selected References

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