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. 2004 Jun-Sep;8(2-3):91–96. doi: 10.1080/1357-7140400001517

Liposarcoma of the Thyroid

A Mitra 1,3,✉, C Fisher 2, P Rhys-Evans 2, C Harmer 2
PMCID: PMC2395612  PMID: 18521401

Abstract

Liposarcoma of the thyroid gland is rare with only 3 cases reported in the English literature. We present a further two patients whom we have recently treated: a 49 year old lady with a myxoid liposarcoma and a 71 year old man with a pleomorphic liposarcoma. Both underwent macroscopic excision of tumour but had positive margins, so were then treated with external beam radiotherapy. The former patient died from metastases 10 months after presentation, the latter remains alive but has developed metastatic disease on follow up at 24 months.

We recommend the use of high dose radiotherapy following radical surgery as margins of excision are usually narrow in this most difficult region. The role of chemotherapy is yet to be established.

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Selected References

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  1. Andrion A., Gaglio A., Dogliani N., Bosco E., Mazzucco G. Liposarcoma of the thyroid gland. Fine-needle aspiration cytology, immunohistology, and ultrastructure. Am J Clin Pathol. 1991 May;95(5):675–679. doi: 10.1093/ajcp/95.5.675. [DOI] [PubMed] [Google Scholar]
  2. Bramwell V., Rouesse J., Steward W., Santoro A., Schraffordt-Koops H., Buesa J., Ruka W., Priario J., Wagener T., Burgers M. Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma--reduced local recurrence but no improvement in survival: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 1994 Jun;12(6):1137–1149. doi: 10.1200/JCO.1994.12.6.1137. [DOI] [PubMed] [Google Scholar]
  3. Cook A. M., Vini L., Harmer C. Squamous cell carcinoma of the thyroid: outcome of treatment in 16 patients. Eur J Surg Oncol. 1999 Dec;25(6):606–609. doi: 10.1053/ejso.1999.0715. [DOI] [PubMed] [Google Scholar]
  4. Edmonson J. H., Ryan L. M., Blum R. H., Brooks J. S., Shiraki M., Frytak S., Parkinson D. R. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J Clin Oncol. 1993 Jul;11(7):1269–1275. doi: 10.1200/JCO.1993.11.7.1269. [DOI] [PubMed] [Google Scholar]
  5. Eeles R. A., Fisher C., A'Hern R. P., Robinson M., Rhys-Evans P., Henk J. M., Archer D., Harmer C. L. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer. 1993 Jul;68(1):201–207. doi: 10.1038/bjc.1993.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harmer C., Bidmead M., Shepherd S., Sharpe A., Vini L. Radiotherapy planning techniques for thyroid cancer. Br J Radiol. 1998 Oct;71(850):1069–1075. doi: 10.1259/bjr.71.850.10211068. [DOI] [PubMed] [Google Scholar]
  7. Jacob R., Gilligan D., Robinson M., Harmer C. Hyper-fractionated radiotherapy for soft tissue sarcoma: results of the second study of hyper-fractionated radiotherapy. Sarcoma. 1999;3(3-4):157–165. doi: 10.1080/13577149977587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nielsen V. T., Knudsen N., Holm I. E. Liposarcoma of the thyroid gland. Tumori. 1986 Oct 31;72(5):499–502. doi: 10.1177/030089168607200508. [DOI] [PubMed] [Google Scholar]
  9. Nutting C. M., Convery D. J., Cosgrove V. P., Rowbottom C., Vini L., Harmer C., Dearnaley D. P., Webb S. Improvements in target coverage and reduced spinal cord irradiation using intensity-modulated radiotherapy (IMRT) in patients with carcinoma of the thyroid gland. Radiother Oncol. 2001 Aug;60(2):173–180. doi: 10.1016/s0167-8140(01)00382-6. [DOI] [PubMed] [Google Scholar]
  10. O'Sullivan Brian, Davis Aileen M., Turcotte Robert, Bell Robert, Catton Charles, Chabot Pierre, Wunder Jay, Kandel Rita, Goddard Karen, Sadura Anna. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet. 2002 Jun 29;359(9325):2235–2241. doi: 10.1016/S0140-6736(02)09292-9. [DOI] [PubMed] [Google Scholar]
  11. Pollack A., Zagars G. K., Goswitz M. S., Pollock R. A., Feig B. W., Pisters P. W. Preoperative vs. postoperative radiotherapy in the treatment of soft tissue sarcomas: a matter of presentation. Int J Radiat Oncol Biol Phys. 1998 Oct 1;42(3):563–572. doi: 10.1016/s0360-3016(98)00277-6. [DOI] [PubMed] [Google Scholar]
  12. Santoro A., Tursz T., Mouridsen H., Verweij J., Steward W., Somers R., Buesa J., Casali P., Spooner D., Rankin E. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J Clin Oncol. 1995 Jul;13(7):1537–1545. doi: 10.1200/JCO.1995.13.7.1537. [DOI] [PubMed] [Google Scholar]
  13. Shiu M. H., Turnbull A. D., Nori D., Hajdu S., Hilaris B. Control of locally advanced extremity soft tissue sarcomas by function-saving resection and brachytherapy. Cancer. 1984 Mar 15;53(6):1385–1392. doi: 10.1002/1097-0142(19840315)53:6<1385::aid-cncr2820530628>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  14. Suit H. D., Proppe K. H., Mankin H. J., Wood W. C. Preoperative radiation therapy for sarcoma of soft tissue. Cancer. 1981 May 1;47(9):2269–2274. doi: 10.1002/1097-0142(19810501)47:9<2269::aid-cncr2820470928>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  15. Suster S., Fisher C. Immunoreactivity for the human hematopoietic progenitor cell antigen (CD34) in lipomatous tumors. Am J Surg Pathol. 1997 Feb;21(2):195–200. doi: 10.1097/00000478-199702000-00009. [DOI] [PubMed] [Google Scholar]

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