Abstract
A controlled field trial comparing the effectiveness of a plain cholera vaccine with that of a vaccine adsorbed to aluminium hydroxide was carried out in a cholera-endemic area of Indonesia during 1973-75. Tetanus toxoid adsorbed to aluminium phosphate was used as the control. In vaccinees aged 1-4 years, the adsorbed cholera vaccine provided about 88% protection for 6 months following vaccination and still provided about 50% protection between 11 and 14 months after vaccination. In the same age group, the plain vaccine provided only 53% protection during the first 6 months and no appreciable protection beyond that period. In those aged 5 years and over, both vaccines provided 50-60% protection throughout the period of observation (14 months). Neither vaccine caused any serious side effects.
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Selected References
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- Mosley W. H., Aziz K. M., Rahman A. S., Chowdhury A. K., Ahmed A. Field trials of monovalent Ogawa and Inaba cholera vaccines in rural Bangladesh--three years of observation. Bull World Health Organ. 1973;49(4):381–387. [PMC free article] [PubMed] [Google Scholar]
- Mosley W. H., Benenson A. S., Barui R. A serological survey for cholera antibodies in rural east Pakistan. 2. A comparison of antibody titres in the innunized and control populationd of a cholera-vaccine field-trial area and the relation of antibody titre to cholera case rate. Bull World Health Organ. 1968;38(3):335–346. [PMC free article] [PubMed] [Google Scholar]
- Mosley W. H., McCormack W. M., Fahimuddin M., Aziz K. M., Rahman A. S., Chowdhury A. K., Martin A. R., Feeley J. C., Phillips R. A. Report of the 1966-67 cholera vaccine field trial in rural East Pakistan. I. Study design and results of the first year of observation. Bull World Health Organ. 1969;40(2):177–185. [PMC free article] [PubMed] [Google Scholar]
- Ogonuki H., Hashizume S., Takashashi B. Preparation and laboratory tests of oil-adjuvant cholera vaccine. Bull World Health Organ. 1967;37(5):729–736. [PMC free article] [PubMed] [Google Scholar]