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. 1979;57(Suppl):231–238.

Recent developments in the assessment of the immune response to malaria, especially as related to vaccination: Malaria infections in different strains of mice and their correlation with natural killer activity*

Elsie M Eugui, Anthony C Allison
PMCID: PMC2395731  PMID: 317441

Abstract

Different mouse strains show marked variation in susceptibility to murine malaria parasites. Of those studied, strain A mice showed the highest susceptibility, most animals dying from Plasmodium chabaudi infections. In contrast, C57Bl and CBA mice all recovered from P. chabaudi infections and were then resistant to challenge with a virulent strain of P. yoelii. BALB/c mice recovered from P. chabaudi infections but were not uniformly resistant to P. yoelii challenge. B10.A mice, which share haplotypes (H-2a) with strain A mice, were resistant to P. chabaudi infections. Of all the correlates of resistance, one appears to be of special interest: natural killer (NK) activity. This was high in C57Bl mice and in malaria-infected mice considerable increases in spleen cell numbers and in NK activity were observed. In contrast, strain A mice showed low NK activity and in malaria-infected animals spleen cell numbers and NK activity showed little or no increase. It is suggested that NK cells, recruited and activated by T lymphocyte-mediated immune responses to parasite antigens, recruit and activate NK cells and macrophages, and that a product of the reacting cells may produce death of parasites within circulating erythrocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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