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. 1980;58(1):67–71.

Neisseria gonorrhoeae isolates from Ethiopia

1. In vitro susceptibility patterns to five antibiotics*

Messele Gedebou, Alebachew Tassew
PMCID: PMC2395889  PMID: 6769599

Abstract

Five hundred Neisseria gonorrhoeae strains isolated between January 1977 and February 1978 from male patients in Addis Ababa were tested by the agar dilution technique for their susceptibility to penicillin, ampicillin, tetracycline, chloramphenicol, and streptomycin.

The minimal inhibitory concentration (MIC) values of penicillin and ampicillin for the isolates varied from ≤0.005 to 1.28 mg/litre and from ≤0.025 to 0.8 mg/litre respectively. The tetracycline values ranged from ≤0.2 to 3.2 mg/litre and those of chloramphenicol from ≤0.125 to 8.0 mg/litre. Streptomycin concentrations of 10, 20, 40, 50, 100, and 200 mg/litre each inhibited growth of a number of strains. 107 strains (21.4%) were not inhibited, even by a concentration of 200 mg/litre, the highest employed.

Forty-one percent of strains were resistant to penicillin, requiring 0.08 mg/litre or a higher concentration for inhibition, and 58.4% were resistant to ampicillin, inhibition occurring only at concentrations ≥0.2 mg/litre. The percentage of strains resistant to penicillin was significantly lower than that reported 7 years ago (50%). Resistance to tetracycline was shown in 8.2% of strains. None of the 500 strains showed resistance to chloramphenicol. Streptomycin resistance was detected in 43.8% of the strains.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arya O. P., Phillips I. Antibiotic sensitivity of gonococci and treatment of gonorrhoea in Uganda. Br J Vener Dis. 1970 Apr;46(2):149–152. doi: 10.1136/sti.46.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CURTIS F. R., WILKINSON A. E. A comparison of the in vitro sensitivity of gonococci to penicillin with the results of treatment. Br J Vener Dis. 1958 Jun;34(2):70–82. doi: 10.1136/sti.34.2.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dodge R. W., Wallace C. K. Neisseria gonorrhoeae in Ethiopia: I. Antibiotic sensitivity pattern. Ethiop Med J. 1975 Jan;13(1):19–22. [PubMed] [Google Scholar]
  4. Gundersen T., Odegaard K., Gjessing H. C. Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined. Br J Vener Dis. 1969 Sep;45(3):235–237. doi: 10.1136/sti.45.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Moses J. M., Desai M. S., Bhosle C. B., Trasi M. S. Present pattern of antibiotic sensitivity of gonococcal strains isolated in Bombay. Br J Vener Dis. 1971 Aug;47(4):273–278. doi: 10.1136/sti.47.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Nielsen R. Sensitivity of gonococci to antibiotics in strains isolated from "prostitutes" in Copenhagen. Br J Vener Dis. 1970 Apr;46(2):153–155. doi: 10.1136/sti.46.2.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Plorde J. J., Kidan T. G., Wright L. J. Penicillin sensitivity of gonococci in Ethiopia. Br J Vener Dis. 1973 Jun;49(3):260–262. doi: 10.1136/sti.49.3.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. REYN A. Sensitivity of N. gonorrhoeae to antibiotics. Br J Vener Dis. 1961 Jun;37:145–157. doi: 10.1136/sti.37.2.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Reyn A. Antibiotic sensitivity of gonococcal strains isolated in the South-East Asia and Western Pacific regions in 1961-68. Bull World Health Organ. 1969;40(2):257–262. [PMC free article] [PubMed] [Google Scholar]
  10. Reyn A., Bentzon M. W. Relationships between the sensitivities in vitro of Neisseria gonorrhoeae to spiramycin, penicillin, streptomycin, tetracycline, and erythromycin. Br J Vener Dis. 1969 Sep;45(3):223–227. doi: 10.1136/sti.45.3.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sparling P. F. Antibiotic resistance in Neisseria gonorrhoeae. Med Clin North Am. 1972 Sep;56(5):1133–1144. doi: 10.1016/s0025-7125(16)32339-2. [DOI] [PubMed] [Google Scholar]
  12. Stolz E., Zwart H. G., Michel M. F. Sensitivity to ampicillin, penicillin, and tetracyline of gonococci in Rotterdam. Br J Vener Dis. 1974 Jun;50(3):202–207. doi: 10.1136/sti.50.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thayer J. D., Martin J. E., Jr Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis. Public Health Rep. 1966 Jun;81(6):559–562. [PMC free article] [PubMed] [Google Scholar]
  14. Thornsberry C., Kirven L. A. Ampicillin resistance in Haemophilus influenzae as determined by a rapid test for beta-lactamase production. Antimicrob Agents Chemother. 1974 Nov;6(5):653–654. doi: 10.1128/aac.6.5.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Verhagen A. R., Van der Ham M., Heimans A. L., Kranendonk O., Maina A. N. Diminished antibiotic sensitivity of Neisseria gonorrhoeae in urban and rural areas in Kenya. Bull World Health Organ. 1971;45(6):707–717. [PMC free article] [PubMed] [Google Scholar]
  16. Wols-Van der Wielen A. Sensitivity to antibiotics of gonococcal strains isolated from sailors at Rotterdam. Br J Vener Dis. 1971 Jun;47(3):190–191. doi: 10.1136/sti.47.3.190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wright L. J., Kidan T. G., Eng S. C., Plorde J. J. Penicillin sensitivity of Neisseria gonorrhoeae isolated in Addis Ababa. Ethiop Med J. 1970 Jul;8(3):119–122. [PubMed] [Google Scholar]

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