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Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1980;58(3):475–483.

Determining the prevalence of tuberculosis infection in populations with non-specific tuberculin sensitivity*

H G ten Dam, K L Hitze
PMCID: PMC2395910  PMID: 6968253

Abstract

In tropical countries, where there is generally a high prevalence of non-specific sensitivity, the tuberculin test is inadequate for detecting tuberculosis infection. A method is proposed by which the prevalence of infection in the population can be determined under such circumstances thus making possible meaningful epidemiological surveillance of the disease. This method compares levels of tuberculin sensitivity in individuals before and after BCG vaccination. If BCG vaccination fails to produce an increase in tuberculin sensitivity, the individual must have been infected with human or bovine tubercle bacilli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Deck F., Guld J. The WHO tuberculin test. Bull Int Union Tuberc. 1964 May;34(1):53–70. [PubMed] [Google Scholar]
  2. Edwards L. B., Palmer C. E. Biology of the mycobacterioses. Identification of the tuberculous-infected by skin tests. Ann N Y Acad Sci. 1968 Sep 5;154(1):140–148. doi: 10.1111/j.1749-6632.1968.tb16704.x. [DOI] [PubMed] [Google Scholar]
  3. GULD J. Quantitative aspects of the intradermal tuberculin test in humans. I. The dose-response function within the range 1-10 tuberculin units, determined by duplicate tests. Acta Tuberc Scand. 1953;28(3-4):222–245. [PubMed] [Google Scholar]
  4. NISSEN-MEYER S. Epidemiologic studies of tuberculin sensitivity. III. Estimation of prevalences of myobacterial infection from results of skin tests with mycobacterial antigens. Am J Hyg. 1960 Sep;72:169–194. [PubMed] [Google Scholar]
  5. Narain R. Interpretation of the repeat tuberculin test. Tubercle. 1968 Mar;49(1):92–103. doi: 10.1016/s0041-3879(68)80011-x. [DOI] [PubMed] [Google Scholar]
  6. Narain R., Vallishayee R. S., Reddy A. V. Value of dual testing with PPD-S and PPD-B. Indian J Med Res. 1978 Aug;68:204–219. [PubMed] [Google Scholar]
  7. PALMER C. E., BATES L. E. Tuberculin sensitivity of tuberculous patients. Bull World Health Organ. 1952;7(2):171–188. [PMC free article] [PubMed] [Google Scholar]
  8. Palmer C. E., Long M. W. Effects of infection with atypical mycobacteria on BCG vaccination and tuberculosis. Am Rev Respir Dis. 1966 Oct;94(4):553–568. doi: 10.1164/arrd.1966.94.4.553. [DOI] [PubMed] [Google Scholar]
  9. ROELSGAARD E., IVERSEN E., BLOCHER C. TUBERCULOSIS IN TROPICAL AFRICA. AN EPIDEMIOLOGICAL STUDY. Bull World Health Organ. 1964;30:459–518. [PMC free article] [PubMed] [Google Scholar]

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