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. 1981;59(3):397–406.

Pharmacology of 8-aminoquinolines

R S Grewal
PMCID: PMC2396079  PMID: 6976847

Abstract

The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs—pentaquine, isopentaquine, and primaquine —of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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