Skip to main content
NCBI home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1984 Feb;47(2):416–418. doi: 10.1128/aem.47.2.416-418.1984

Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid.

M Gareis, J Bauer, A von Montgelas, B Gedek
PMCID: PMC239684  PMID: 6424567

Abstract

Aspergillus flavus grown on yeast extract-sucrose medium produced higher amounts of aflatoxin B1 in the presence of 0.025% sorbic acid than without this chemical with a maximum at 17 days of incubation. Addition of 0.05 to 0.0125% sorbic acid stimulated T-2 toxin production of Fusarium acuminatum cultures grown on maize meal. The highest amounts of the mycotoxin were detected in 14-day-old cultures containing 0.025% sorbic acid. It is assumed that certain amounts of sorbic acid near the minimal inhibitory concentration reduce the activity of the tricarboxylic acid cycle; this may lead to an accumulation of acetyl coenzyme A, which is an essential intermediate in the biosynthesis of aflatoxin B1 and T-2 toxin.

Full text

PDF
416

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chipley J. R., Uraih N. Inhibition of Aspergillus growth and aflatoxin release by derivatives of benzoic acid. Appl Environ Microbiol. 1980 Aug;40(2):352–357. doi: 10.1128/aem.40.2.352-357.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Davis N. D., Diener U. L., Eldridge D. W. Production of aflatoxins B1 and G1 by Aspergillus flavus in a semisynthetic medium. Appl Microbiol. 1966 May;14(3):378–380. doi: 10.1128/am.14.3.378-380.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Draughon F. A., Ayres J. C. Inhibition of aflatoxin production by selected insecticides. Appl Environ Microbiol. 1981 Apr;41(4):972–976. doi: 10.1128/aem.41.4.972-976.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gupta S. K., Maggon K. K., Venkitasubramanian T. A. Effect of zinc on adenine nucleotide pools in relation to aflatoxin biosynthesis in Aspergillus parasiticus. Appl Environ Microbiol. 1976 Dec;32(6):753–756. doi: 10.1128/aem.32.6.753-756.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hitokoto H., Morozumi S., Wauke T., Sakai S., Kurata H. Inhibitory effects of spices on growth and toxin production of toxigenic fungi. Appl Environ Microbiol. 1980 Apr;39(4):818–822. doi: 10.1128/aem.39.4.818-822.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hitokoto H., Morozumi S., Wauke T., Sakai S., Ueno I. Inhibitory effects of condiments and herbal drugs on the growth and toxin production of toxigenic fungi. Mycopathologia. 1979 Feb 28;66(3):161–167. doi: 10.1007/BF00683965. [DOI] [PubMed] [Google Scholar]
  7. Jarvis B. Symposium on microbial changes in foods. Factors affecting the production of mycotoxins. J Appl Bacteriol. 1971 Mar;34(1):199–213. doi: 10.1111/j.1365-2672.1971.tb02278.x. [DOI] [PubMed] [Google Scholar]
  8. McGinnis M. R., Padhye A. A., Ajello L. Storage of stock cultures of filamentous fungi, yeasts, and some aerobic actinomycetes in sterile distilled water. Appl Microbiol. 1974 Aug;28(2):218–222. doi: 10.1128/am.28.2.218-222.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rabie C. J., Meyer C. J., van Heerden L., Lübben A. Inhibitory effect of molybdenum and vanadium salts on aflatoxin B1 synthesis by Aspergillus flavus. Can J Microbiol. 1981 Sep;27(9):962–967. doi: 10.1139/m81-152. [DOI] [PubMed] [Google Scholar]
  10. Rao H. R., Harein P. K. Inhibition of aflatoxin and zearalenone biosynthesis with dichlorvos. Bull Environ Contam Toxicol. 1973 Aug;10(2):112–115. doi: 10.1007/BF01685882. [DOI] [PubMed] [Google Scholar]
  11. Romer T. R., Boling T. M., MacDonald J. L. Gas-liquid chromatographic determination of T-2 toxin and diacetoxyscirpenol in corn and mixed feeds. J Assoc Off Anal Chem. 1978 Jul;61(4):801–808. [PubMed] [Google Scholar]
  12. Shantha T., Murthy V. S. Influence of tricarboxylic acid cycle intermediates and related metabolites on the biosynthesis of aflatoxin by resting cells of Aspergillus flavus. Appl Environ Microbiol. 1981 Nov;42(5):758–761. doi: 10.1128/aem.42.5.758-761.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stack M. E., Pohland A. E. Collaborative study of a method for chemical confirmation of the identity of aflatoxin. J Assoc Off Anal Chem. 1975 Jan;58(1):110–113. [PubMed] [Google Scholar]
  14. Stewart R. G., Wyatt R. D., Ashmore M. D. The effect of various antifungal agents on aflatoxin production and growth characteristics of Aspergillus parasiticus and Aspergillus flavus in liquid medium. Poult Sci. 1977 Sep;56(5):1630–1635. doi: 10.3382/ps.0561630. [DOI] [PubMed] [Google Scholar]
  15. Uraih N., Chipley J. R. Effects of various acids and salts on growth and aflatoxin production by Aspergillus flavus NRRL 3145. Microbios. 1976;17(67):51–59. [PubMed] [Google Scholar]
  16. YORK G. K., VAUGHN R. H. MECHANISMS IN THE INHIBITION OF MICROORGANISMS BY SORBIC ACID. J Bacteriol. 1964 Aug;88:411–417. doi: 10.1128/jb.88.2.411-417.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES