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. 1984 Mar;47(3):481–483. doi: 10.1128/aem.47.3.481-483.1984

Averufin, an anthraquinone mycotoxin possessing a potent uncoupling effect on mitochondrial respiration.

K Kawai, Y Nozawa, Y Maebayashi, M Yamazaki, T Hamasaki
PMCID: PMC239706  PMID: 6712217

Abstract

Averufin and averufin dimethylether from Aspergillus versicolor were examined for their uncoupling effects on oxidative phosphorylation in isolated rat liver mitochondria to get insight into the mode of toxic action of averufin. Averufin uncoupled oxidative phosphorylation, causing 50% uncoupling at about 1.5 microM with respect to the decrease in P/O ratio. Averufin dimethylether did not uncouple but inhibited state 3 respiration of mitochondria, which was not released by either 2,4-dinitrophenol or averufin.

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Selected References

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