Abstract
A patient suffering from migraine, whose symptoms were abolished by warfarin therapy, is reported. Warfarin was prescribed for deep vein thrombosis and the frequency of the patient's headache improved remarkably during the anticoagulant therapy. Because of the unusual nature of the response to anticoagulant therapy, warfarin was reintroduced on a double blind (versus placebo) basis and once again abolished the headaches.
Full text
PDF

Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Deshmukh S. V., Meyer J. S. Cyclic changes in platelet dynamics and the pathogenesis and prophylaxis of migraine. Headache. 1977 Jul;17(3):101–108. doi: 10.1111/j.1526-4610.1977.hed1703101.x. [DOI] [PubMed] [Google Scholar]
- Leviton A., Camenga D. Migraine associated with hyper-pre-beta lipoproteinemia. Neurology. 1969 Oct;19(10):963–966. doi: 10.1212/wnl.19.10.963. [DOI] [PubMed] [Google Scholar]
- Narasimhan P. Letter: Decreased sensitivity to oral anticoagulant therapy after attacks of migraine. Lancet. 1974 Nov 9;2(7889):1143–1143. doi: 10.1016/s0140-6736(74)90905-2. [DOI] [PubMed] [Google Scholar]
- Thonnard-Neumann E. Migraine therapy with heparin: pathophysiologic basis. Headache. 1977 Jan;16(6):284–292. doi: 10.1111/j.1526-4610.1976.hed1606284.x. [DOI] [PubMed] [Google Scholar]