Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1994 Feb;70(820):115–117. doi: 10.1136/pgmj.70.820.115

Benign intracranial hypertension after pituitary surgery for Cushing's disease.

V J Parfitt 1, J C Dearlove 1, D Savage 1, H B Griffith 1, M Hartog 1
PMCID: PMC2397640  PMID: 8170882

Abstract

An 11 year old girl underwent successful transsphenoidal pituitary adenomectomy for pituitary-dependent Cushing's syndrome. Three months after operation, just after stopping glucocorticoid replacement therapy, she developed benign intracranial hypertension. This resolved when exogenous glucocorticoids were restarted but occurred again when they were later stopped. On restarting glucocorticoids again, this second episode of intracranial hypertension resolved. This complication may have been due to the large fall in endogenous cortisol production after removal of her adenoma and subsequent persistent mild endogenous hypocortisolism.

Full text

PDF
115

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fischer E. G., Anast C. S. Pseudotumor cerebri following removal of an adrenocorticotropic hormone-secreting pituitary adenoma. Neurosurgery. 1982 Feb;10(2):297–297. doi: 10.1097/00006123-198202000-00023. [DOI] [PubMed] [Google Scholar]
  2. Fishman R. A. The pathophysiology of pseudotumor cerebri. An unsolved puzzle. Arch Neurol. 1984 Mar;41(3):257–258. doi: 10.1001/archneur.1984.04050150035011. [DOI] [PubMed] [Google Scholar]
  3. Hopwood N. J., Kenny F. M. Incidence of Nelson's syndrome after adrenalectomy for Cushing's disease in children: results of a nationwide survey. Am J Dis Child. 1977 Dec;131(12):1353–1356. doi: 10.1001/archpedi.1977.02120250035005. [DOI] [PubMed] [Google Scholar]
  4. Johnston I., Gilday D. L., Hendrick E. B. Experimental effects of steroids and steroid withdrawal on cerebrospinal fluid absorption. J Neurosurg. 1975 Jun;42(6):690–695. doi: 10.3171/jns.1975.42.6.0690. [DOI] [PubMed] [Google Scholar]
  5. Martin N. A., Linfoot J., Wilson C. B. Development of pseudotumor cerebri after the removal of an adrenocorticotropic hormone-secreting pituitary adenoma: case report. Neurosurgery. 1981 Jun;8(6):699–702. doi: 10.1227/00006123-198106000-00011. [DOI] [PubMed] [Google Scholar]
  6. Newman P. K., Snow M., Hudgson P. Benign intracranial hypertension and Cushing's disease. Br Med J. 1980 Jul 12;281(6233):113–113. doi: 10.1136/bmj.281.6233.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Raichle M. E., Grubb R. L., Jr, Phelps M. E., Gado M. H., Caronna J. J. Cerebral hemodynamics and metabolism in pseudotumor cerebri. Ann Neurol. 1978 Aug;4(2):104–111. doi: 10.1002/ana.410040203. [DOI] [PubMed] [Google Scholar]
  8. Sklar F. H., Beyer C. W., Jr, Ramanathan M., Cooper P. R., Clark W. K. Cerebrospinal fluid dynamics in patients with pseudotumor cerebri. Neurosurgery. 1979 Aug;5(2):208–216. doi: 10.1227/00006123-197908000-00003. [DOI] [PubMed] [Google Scholar]
  9. Weissman M. N., Page L. K., Bejar R. L. Cushing's disease in childhood: benign intracranial hypertension after trans-sphenoidal adenomectomy. Case report. Neurosurgery. 1983 Aug;13(2):195–198. doi: 10.1227/00006123-198308000-00017. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES