Abstract
Thrombolysis has been very effective in reducing the morbidity and mortality from acute myocardial infarction. Serious adverse events are not uncommon, however. We describe a case in which a haemopericardium and tamponade developed in a patient with a history of recurrent idiopathic pericarditis and to whom streptokinase had been administered following a suspected myocardial infarction. The case highlights the need for caution in the administration of thrombolytics to patients with a documented history of pericarditis.
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Selected References
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- Belkin R. N., Mark D. B., Aronson L., Szwed H., Califf R. M., Kisslo J. Pericardial effusion after intravenous recombinant tissue-type plasminogen activator for acute myocardial infarction. Am J Cardiol. 1991 Mar 1;67(6):496–500. doi: 10.1016/0002-9149(91)90010-i. [DOI] [PubMed] [Google Scholar]
- Blankenship J. C., Almquist A. K. Cardiovascular complications of thrombolytic therapy in patients with a mistaken diagnosis of acute myocardial infarction. J Am Coll Cardiol. 1989 Nov 15;14(6):1579–1582. doi: 10.1016/0735-1097(89)90402-6. [DOI] [PubMed] [Google Scholar]
- Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet. 1988 Aug 13;2(8607):349–360. [PubMed] [Google Scholar]
- Renkin J., de Bruyne B., Benit E., Joris J. M., Carlier M., Col J. Cardiac tamponade early after thrombolysis for acute myocardial infarction: a rare but not reported hemorrhagic complication. J Am Coll Cardiol. 1991 Jan;17(1):280–285. doi: 10.1016/0735-1097(91)90739-v. [DOI] [PubMed] [Google Scholar]
