Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1994 Jun;70(824):457–458. doi: 10.1136/pgmj.70.824.457

Reversible digital clubbing in acute myeloid leukaemia.

S Bhandari 1, M A Wodzinski 1, J T Reilly 1
PMCID: PMC2397729  PMID: 8029171

Abstract

A 43 year old woman presented with acute myeloid leukaemia, marked finger and toe clubbing, and a hilar mass. Biopsy of the hilar mass was not technically possible, but it almost certainly represented a granulocytic sarcoma since chemotherapy induced rapid resolution of the mass along with reversal of the clubbing and remission of the leukaemia. Relapse of the leukaemia 21 months later was associated with return of the clubbing. It is hypothesized that an abnormal circulation within the granulocytic sarcoma may have accounted for the development of clubbing.

Full text

PDF
457

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atkinson M. K., McElwain T. J., Peckham M. J., Thomas P. P. Hypertrophic pulmonary osteoarthropathy in Hodgkin's disease: reversal with chemotherapy. Cancer. 1976 Oct;38(4):1729–1734. doi: 10.1002/1097-0142(197610)38:4<1729::aid-cncr2820380446>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  2. CALVERT R. J., SMITH E. Metastatic acropachy in lymphatic leukemia. Blood. 1955 May;10(5):545–549. [PubMed] [Google Scholar]
  3. COURY C. Hippocration fingers and hypertrophic osteoarthropathy. A study of 350 cases. Br J Dis Chest. 1960;54:202–209. doi: 10.1016/s0007-0971(60)80001-0. [DOI] [PubMed] [Google Scholar]
  4. Dickinson C. J., Martin J. F. Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet. 1987 Dec 19;2(8573):1434–1435. doi: 10.1016/s0140-6736(87)91132-9. [DOI] [PubMed] [Google Scholar]
  5. Garaventa A., Dallorso S., Savioli C., Rosanda C., De Bernardi B. Granulocytic sarcoma presenting as an isolated mediastinal mass. A difficult diagnostic problem. Acta Paediatr Scand. 1989 May;78(3):473–475. doi: 10.1111/j.1651-2227.1989.tb11115.x. [DOI] [PubMed] [Google Scholar]
  6. Muss H. B., Moloney W. C. Chloroma and other myeloblastic tumors. Blood. 1973 Nov;42(5):721–728. [PubMed] [Google Scholar]
  7. Neiman R. S., Barcos M., Berard C., Bonner H., Mann R., Rydell R. E., Bennett J. M. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer. 1981 Sep 15;48(6):1426–1437. doi: 10.1002/1097-0142(19810915)48:6<1426::aid-cncr2820480626>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  8. Papavasiliou C., Pavlatou M., Pappas J. Nasopharyngeal cancer in patients under the age of thirty years. Cancer. 1977 Nov;40(5):2312–2316. doi: 10.1002/1097-0142(197711)40:5<2312::aid-cncr2820400545>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  9. Swirsky D. M., Li Y. S., Matthews J. G., Flemans R. J., Rees J. K., Hayhoe F. G. 8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features. Br J Haematol. 1984 Feb;56(2):199–213. doi: 10.1111/j.1365-2141.1984.tb03948.x. [DOI] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES