Abstract
Two patients sustained the rare complication of skin infarction following administration of intravenous streptokinase for acute myocardial infarction. We report evidence that dissolution of thrombus from an unsuspected source and subsequent microembolization of the skin may be responsible for this complication. In patients known to have an aortic aneurysm or ventricular thrombus, careful consideration should be given to the use of intravenous streptokinase following myocardial infarction.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arora R. R., Magun A. M., Grossman M., Katz J. Cholesterol embolization syndrome after intravenous tissue plasminogen activator for acute myocardial infarction. Am Heart J. 1993 Jul;126(1):225–228. doi: 10.1016/s0002-8703(07)80034-2. [DOI] [PubMed] [Google Scholar]
- Arpesani A., Beretta L., Giorgetti P. L., Varesi C., Matturri L. Sindrome da mobilizzazione di materiale ateromasico a seguito di trattamento trombolitico con streptokinasi per infarto miocardico acuto. Minerva Cardioangiol. 1991 Jun;39(6):251–254. [PubMed] [Google Scholar]
- Bednarczyk E. M., Sherlock S. C., Farah M. G., Green J. A. Anaphylactic reaction to streptokinase with first exposure: case report and review of the literature. DICP. 1989 Nov;23(11):869–872. doi: 10.1177/106002808902301106. [DOI] [PubMed] [Google Scholar]
- Blazer D., Degroat T., Kotler M. N., Nakhjavan F., Parameswaran R., McGowan C., Parry W. R. Peripheral embolization during thrombolytic therapy for left atrial thrombus. Am J Cardiol. 1986 Sep 1;58(6):554–555. doi: 10.1016/0002-9149(86)90034-2. [DOI] [PubMed] [Google Scholar]
- Hannaford P., Kay C. R. Back pain and thrombolysis. BMJ. 1992 Apr 4;304(6831):915–915. doi: 10.1136/bmj.304.6831.915. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmström M., Bratt G., Törnebohm E., Rhedin A. S., Lockner D. Fatal pulmonary embolism caused by streptokinase treatment of deep venous thrombosis of the leg? J Intern Med. 1990 Dec;228(6):647–649. doi: 10.1111/j.1365-2796.1990.tb00293.x. [DOI] [PubMed] [Google Scholar]
- Pirson Y., Honhon B., Cosyns J. P., van Ypersele C. Cholesterol embolism in a renal graft after treatment with streptokinase. Br Med J (Clin Res Ed) 1988 Feb 6;296(6619):394–395. doi: 10.1136/bmj.296.6619.394-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz M. W., McDonald G. B. Cholesterol embolization syndrome. Occurrence after intravenous streptokinase therapy for myocardial infarction. JAMA. 1987 Oct 9;258(14):1934–1935. doi: 10.1001/jama.258.14.1934. [DOI] [PubMed] [Google Scholar]
- Shah M., Taylor R. T. Low back pain associated with streptokinase. BMJ. 1990 Nov 24;301(6762):1219–1219. doi: 10.1136/bmj.301.6762.1219-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stafford P. J., Strachan C. J., Vincent R., Chamberlain D. A. Multiple microemboli after disintegration of clot during thrombolysis for acute myocardial infarction. BMJ. 1989 Nov 25;299(6711):1310–1312. doi: 10.1136/bmj.299.6711.1310. [DOI] [PMC free article] [PubMed] [Google Scholar]