Skip to main content
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1984 Apr;47(4):868–869. doi: 10.1128/aem.47.4.868-869.1984

Chloramphenicol acetyltransferase should not provide methanogens with resistance to chloramphenicol.

G S Beckler, L A Hook, J N Reeve
PMCID: PMC239778  PMID: 6372691

Abstract

Growth of the four methanogens investigated was inhibited by chloramphenicol-3-acetate; therefore, introduction of chloramphenicol acetyltransferase-encoding genes should not confer chloramphenicol resistance on these methanogens. Reduction of the aryl nitro group of chloramphenicol produced a compound which did not inhibit the growth of these methanogens.

Full text

PDF
868

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. McKellar R. C., Sprott G. D. Solubilization and properties of a particulate hydrogenase from Methanobacterium strain G2R. J Bacteriol. 1979 Jul;139(1):231–238. doi: 10.1128/jb.139.1.231-238.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. O'Brien R. W., Morris J. G. The Ferredoxin-dependent reduction of chloramphenicol by clostridium acetobutylicum. J Gen Microbiol. 1971 Aug;67(3):265–271. doi: 10.1099/00221287-67-3-265. [DOI] [PubMed] [Google Scholar]
  3. Reeve J. N., Trun N. J., Hamilton P. T. Beginning genetics with methanogens. Basic Life Sci. 1982;19:233–244. doi: 10.1007/978-1-4684-4142-0_19. [DOI] [PubMed] [Google Scholar]
  4. SMITH G. N., WORREL C. S. The application of paper-partition chromatography to the analysis of chloramphenicol (chloromycetin) and decomposition products. Arch Biochem. 1950 Aug;28(1):1–9. [PubMed] [Google Scholar]
  5. SMITH G. N., WORREL C. S. The decomposition of chloromycetin (chloramphenicol) by microorganisms. Arch Biochem. 1950 Sep;28(2):232–241. [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES