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. 1995 Jan;71(831):24–27. doi: 10.1136/pgmj.71.831.24

Chronic suppurative lung disease with associated vasculitis.

I N Bruce 1, J A McAteer 1, P V Gardiner 1, R J McFarland 1, J M Sloan 1, A L Bell 1
PMCID: PMC2397893  PMID: 7708587

Abstract

We report a patient with chronic bronchiectasis who developed systemic vasculitis. The patient was initially treated with immunosuppression; however, the addition of antibiotic therapy improved control of her vasculitis and the need for immunosuppression was reduced. Chronic bronchial suppuration may have an aetiological role in the pathogenesis of this condition.

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Selected References

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  1. Butland R. J., Cole P., Citron K. M., Turner-Warwick M. Chronic bronchial suppuration and inflammatory bowel disease. Q J Med. 1981;50(197):63–75. [PubMed] [Google Scholar]
  2. Dubost J. J., Souteyrand P., Sauvezie B. Drug-induced vasculitides. Baillieres Clin Rheumatol. 1991 Apr;5(1):119–138. doi: 10.1016/s0950-3579(05)80299-7. [DOI] [PubMed] [Google Scholar]
  3. Efthimiou J., Spickett G., Lane D., Thompson A. Antineutrophil cytoplasmic antibodies, cystic fibrosis, and infection. Lancet. 1991 Apr 27;337(8748):1037–1038. doi: 10.1016/0140-6736(91)92694-w. [DOI] [PubMed] [Google Scholar]
  4. Falk R. J., Terrell R. S., Charles L. A., Jennette J. C. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4115–4119. doi: 10.1073/pnas.87.11.4115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Finnegan M. J., Hinchcliffe J., Russell-Jones D., Neill S., Sheffield E., Jayne D., Wise A., Hodson M. E. Vasculitis complicating cystic fibrosis. Q J Med. 1989 Jul;72(267):609–621. [PubMed] [Google Scholar]
  6. Fradin M. S., Kalb R. E., Grossman M. E. Recurrent cutaneous vasculitis in cystic fibrosis. Pediatr Dermatol. 1987 Aug;4(2):108–111. doi: 10.1111/j.1525-1470.1987.tb00763.x. [DOI] [PubMed] [Google Scholar]
  7. Gorevic P. D., Kassab H. J., Levo Y., Kohn R., Meltzer M., Prose P., Franklin E. C. Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am J Med. 1980 Aug;69(2):287–308. doi: 10.1016/0002-9343(80)90390-3. [DOI] [PubMed] [Google Scholar]
  8. Gross W. L., Hauschild S., Mistry N. The clinical relevance of ANCA in vasculitis. Clin Exp Immunol. 1993 Sep;93 (Suppl 1):7–11. doi: 10.1111/j.1365-2249.1993.tb06215.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hilton A. M., Doyle L. Immunological abnormalities in bronchiectasis with chronic bronchial suppuration. Br J Dis Chest. 1978 Jul;72(3):207–216. doi: 10.1016/0007-0971(78)90043-8. [DOI] [PubMed] [Google Scholar]
  10. Hilton A. M., Hasleton P. S., Bradlow A., Leahy B. C., Cooper K. M., Moore M. Cutaneous vasculitis and immune complexes in severe bronchiectasis. Thorax. 1984 Mar;39(3):185–191. doi: 10.1136/thx.39.3.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Israel H. L. Sulfamethoxazole-trimethoprim therapy for Wegener's granulomatosis. Arch Intern Med. 1988 Oct;148(10):2293–2295. [PubMed] [Google Scholar]
  12. John E. G., Medenis R., Rao S. Cutaneous necrotizing venulitis in patients with cystic fibrosis. J Pediatr. 1980 Sep;97(3):505–505. doi: 10.1016/s0022-3476(80)80226-5. [DOI] [PubMed] [Google Scholar]
  13. Kyle R. A., Gleich G. J., Bayrid E. D., Vaughan J. H. Benign hypergammaglobulinemic purpura of Waldenström. Medicine (Baltimore) 1971 Mar;50(2):113–123. doi: 10.1097/00005792-197103000-00003. [DOI] [PubMed] [Google Scholar]
  14. Moss R. B., Hsu Y. P. Isolation and characterization of circulating immune complexes in cystic fibrosis. Clin Exp Immunol. 1982 Feb;47(2):301–308. [PMC free article] [PubMed] [Google Scholar]
  15. Moss R. B., Lewiston N. J. Immune complexes and humoral response to Pseudomonas aeruginosa in cystic fibrosis. Am Rev Respir Dis. 1980 Jan;121(1):23–29. doi: 10.1164/arrd.1980.121.1.23. [DOI] [PubMed] [Google Scholar]
  16. Mullick F. G., McAllister H. A., Jr, Wagner B. M., Fenoglio J. J., Jr Drug related vasculitis. Clinicopathologic correlations in 30 patients. Hum Pathol. 1979 May;10(3):313–325. doi: 10.1016/s0046-8177(79)80028-3. [DOI] [PubMed] [Google Scholar]
  17. Nielsen H. E., Lundh S., Jacobsen S. V., Høiby N. Hypergammaglobulinemic purpura in cystic fibrosis. Acta Paediatr Scand. 1978 Jul;67(4):443–447. doi: 10.1111/j.1651-2227.1978.tb16351.x. [DOI] [PubMed] [Google Scholar]
  18. Norman D., Elborn J. S., Cordon S. M., Rayner R. J., Wiseman M. S., Hiller E. J., Shale D. J. Plasma tumour necrosis factor alpha in cystic fibrosis. Thorax. 1991 Feb;46(2):91–95. doi: 10.1136/thx.46.2.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pinching A. J., Lockwood C. M., Pussell B. A., Rees A. J., Sweny P., Evans D. J., Bowley N., Peters D. K. Wegener's granulomatosis: observations on 18 patients with severe renal disease. Q J Med. 1983 Autumn;52(208):435–460. [PubMed] [Google Scholar]
  20. Pitcher-Wilmott R. W., Levinsky R. J., Matthew D. J. Circulating soluble immune complexes containing pseudomonas antigens in cystic fibrosis. Arch Dis Child. 1982 Aug;57(8):577–581. doi: 10.1136/adc.57.8.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Savage C. O., Gaskin G., Pusey C. D., Pearson J. D. Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens. Exp Nephrol. 1993 May-Jun;1(3):190–195. [PubMed] [Google Scholar]
  22. Schuger L., Varani J., Marks R. M., Kunkel S. L., Johnson K. J., Ward P. A. Cytotoxicity of tumor necrosis factor-alpha for human umbilical vein endothelial cells. Lab Invest. 1989 Jul;61(1):62–68. [PubMed] [Google Scholar]
  23. Sitara D., Hoffbrand B. I. Chronic bronchial suppuration and antineutrophil cytoplasmic antibody (ANCA) positive systemic vasculitis. Postgrad Med J. 1990 Aug;66(778):669–671. doi: 10.1136/pgmj.66.778.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Solanki T., Neville E. Bronchiectasis and rheumatoid disease: is there an association? Br J Rheumatol. 1992 Oct;31(10):691–693. doi: 10.1093/rheumatology/31.10.691. [DOI] [PubMed] [Google Scholar]
  25. Soter N. A., Mihm M. C., Jr, Colten H. R. Cutaneous necrotizing venulitis in patients with cystic fibrosis. J Pediatr. 1979 Aug;95(2):197–201. doi: 10.1016/s0022-3476(79)80650-2. [DOI] [PubMed] [Google Scholar]
  26. Tanaka E., Tada K., Amitani R., Kuze F. Systemic hypersensitivity vasculitis associated with bronchiectasis. Chest. 1992 Aug;102(2):647–649. doi: 10.1378/chest.102.2.647. [DOI] [PubMed] [Google Scholar]
  27. Walker W. C. Pulmonary infections and rheumatoid arthritis. Q J Med. 1967 Apr;36(142):239–251. [PubMed] [Google Scholar]

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