Abstract
This study was carried out on 70 patients with haematological or solid malignancies who were receiving chemotherapy and/or radiotherapy. Forty-one patients were randomly assigned to receive fluconazole, 400 mg/day, while they were neutropenic. Systemic fungal infection developed in four of the 41 patients (9%) receiving prophylaxis in comparison to nine of 29 patients (31%) not receiving prophylaxis. The incidence of systemic fungal infection was significantly different between the groups receiving prophylaxis and those not receiving it (p < 0.05). Fluconazole was found to be effective for preventing systemic fungal infections in neutropenic patients with cancer.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bodey G. P. Infection in cancer patients. A continuing association. Am J Med. 1986 Jul 28;81(1A):11–26. doi: 10.1016/0002-9343(86)90510-3. [DOI] [PubMed] [Google Scholar]
- Goodman J. L., Winston D. J., Greenfield R. A., Chandrasekar P. H., Fox B., Kaizer H., Shadduck R. K., Shea T. C., Stiff P., Friedman D. J. A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med. 1992 Mar 26;326(13):845–851. doi: 10.1056/NEJM199203263261301. [DOI] [PubMed] [Google Scholar]
- Graybill J. R. New antifungal agents. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):402–412. doi: 10.1007/BF01964056. [DOI] [PubMed] [Google Scholar]
- Meunier F. Candidiasis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):438–447. doi: 10.1007/BF01964058. [DOI] [PubMed] [Google Scholar]
- Richet H. M., Andremont A., Tancrede C., Pico J. L., Jarvis W. R. Risk factors for candidemia in patients with acute lymphocytic leukemia. Rev Infect Dis. 1991 Mar-Apr;13(2):211–215. doi: 10.1093/clinids/13.2.211. [DOI] [PubMed] [Google Scholar]
- Saral R. Candida and Aspergillus infections in immunocompromised patients: an overview. Rev Infect Dis. 1991 May-Jun;13(3):487–492. doi: 10.1093/clinids/13.3.487. [DOI] [PubMed] [Google Scholar]
- Sugar A. M. Empiric treatment of fungal infections in the neutropenic host. Review of the literature and guidelines for use. Arch Intern Med. 1990 Nov;150(11):2258–2264. [PubMed] [Google Scholar]
- Walsh T. J., Lee J., Lecciones J., Rubin M., Butler K., Francis P., Weinberger M., Roilides E., Marshall D., Gress J. Empiric therapy with amphotericin B in febrile granulocytopenic patients. Rev Infect Dis. 1991 May-Jun;13(3):496–503. doi: 10.1093/clinids/13.3.496. [DOI] [PubMed] [Google Scholar]
- Winston D. J., Chandrasekar P. H., Lazarus H. M., Goodman J. L., Silber J. L., Horowitz H., Shadduck R. K., Rosenfeld C. S., Ho W. G., Islam M. Z. Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled, double-blind, multicenter trial. Ann Intern Med. 1993 Apr 1;118(7):495–503. doi: 10.7326/0003-4819-118-7-199304010-00003. [DOI] [PubMed] [Google Scholar]