Abstract
We have administered octreotide, 100 micrograms tid, to a 27-year-old man with Nelson's syndrome. After seven days of therapy, adrenocorticotropin levels fell to 54% of initial values, and some shrinkage of the tumour was observed. This study indicates that octreotide therapy may have a role in the treatment of Nelson's syndrome.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Lamberts S. W., Oosterom R., Verleun T., Bons E. G., Uitterlinden P. A met-enkephalin analog inhibits adrenocorticotropin secretion by cultured pituitary cells from a patient with Nelson's syndrome. J Clin Endocrinol Metab. 1981 Nov;53(5):1084–1086. doi: 10.1210/jcem-53-5-1084. [DOI] [PubMed] [Google Scholar]
- Lamberts S. W., Uitterlinden P., Klijn J. M. The effect of the long-acting somatostatin analogue SMS 201-995 on ACTH secretion in Nelson's syndrome and Cushing's disease. Acta Endocrinol (Copenh) 1989 Jun;120(6):760–766. doi: 10.1530/acta.0.1200760. [DOI] [PubMed] [Google Scholar]
- Lamberts S. W., Zuyderwijk J., den Holder F., van Koetsveld P., Hofland L. Studies on the conditions determining the inhibitory effect of somatostatin on adrenocorticotropin, prolactin and thyrotropin release by cultured rat pituitary cells. Neuroendocrinology. 1989 Jul;50(1):44–50. doi: 10.1159/000125200. [DOI] [PubMed] [Google Scholar]
- Shibasaki T., Masui H. Effects of various neuropeptides on the secretion of proopiomelanocortin-derived peptides by a cultured pituitary adenoma causing Nelson's syndrome. J Clin Endocrinol Metab. 1982 Nov;55(5):872–876. doi: 10.1210/jcem-55-5-872. [DOI] [PubMed] [Google Scholar]
- Tyrrell J. B., Lorenzi M., Gerich J. E., Forsham P. H. Inhibition by somatostatin of ACTH secretion in Nelson's syndrome. J Clin Endocrinol Metab. 1975 Jun;40(6):1125–1127. doi: 10.1210/jcem-40-6-1125. [DOI] [PubMed] [Google Scholar]
- Utas C., Kelestimur F., Boyaci A., Saglam A. Control of plasma glucose with somatostatin analogue (SMS 201-995) during surgical removal of insulinomas. Postgrad Med J. 1993 Dec;69(818):920–921. doi: 10.1136/pgmj.69.818.920. [DOI] [PMC free article] [PubMed] [Google Scholar]