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. 1996 Feb;72(844):113–114. doi: 10.1136/pgmj.72.844.113

Bleeding in a patient taking Lorenzo's oil: evidence for a vascular defect.

B C Chai 1, W S Etches 1, M W Stewart 1, K Siminoski 1
PMCID: PMC2398367  PMID: 8871463

Abstract

We describe a man with adrenoleukodystrophy receiving Lorenzo's oil (glycerol trioleate and glycerol trierucate) who developed purpura, petechiae, and bleeding. Bleeding time was markedly increased (>20 min), although he had only borderline thrombocytopenia (120 x 10(9)/1) and conventional platelet aggregation studies were normal (except for a borderline response to low concentration collagen), as were results using a new technique employing immobilised von Willebrand factor. Together these results suggest that bleeding in this man resulted from a defect in vascular wall function or in the interaction of platelets with the endothelium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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