Abstract
We describe a young woman with primary adrenal insufficiency, hypoparathyroidism (autoimmune polyglandular syndrome type 1), Graves disease, vitiligo, and alopecia universalis. Five years after the diagnosis, she presented with recurrent ophthalmological and neurological disorders as features of Vogt-Koyanagi-Harada syndrome. A marked therapeutic response was noted on systemic high-dose corticosteroid treatment. To the best of our knowledge, such a spectre of autoimmune diseases has not been reported previously.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ahonen P., Koskimies S., Lokki M. L., Tiilikainen A., Perheentupa J. The expression of autoimmune polyglandular disease type I appears associated with several HLA-A antigens but not with HLA-DR. J Clin Endocrinol Metab. 1988 Jun;66(6):1152–1157. doi: 10.1210/jcem-66-6-1152. [DOI] [PubMed] [Google Scholar]
- Brun J. M. Les polyendocrinopathies juvéniles auto-immunes. Ann Endocrinol (Paris) 1978;39(6):463–481. [PubMed] [Google Scholar]
- Jaggarao N., Voth D., Jacobsen J. The Vogt-Koyanagi-Harada syndrome: association with hypothyroidism and diabetes mellitus. Postgrad Med J. 1989 Aug;65(766):587–588. doi: 10.1136/pgmj.65.766.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kogiso M., Tanouchi Y., Miki S., Mimura Y. Characterization of T-cell subsets, soluble interleukin-2 receptors and interleukin-6 in Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol. 1992;36(1):37–43. [PubMed] [Google Scholar]
- Peserico A., Rigon F., Semenzato G., Caretto A., Pasini C. V., Betterle C. Vitiligo and polyglandular autoimmune disease with autoantibodies to melanin-producing cells. A new syndrome? Arch Dermatol. 1981 Nov;117(11):751–752. [PubMed] [Google Scholar]
- Snyder D. A., Tessler H. H. Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1980 Jul;90(1):69–75. [PubMed] [Google Scholar]
- Weetman A. P. Autoimmunity to steroid-producing cells and familial polyendocrine autoimmunity. Baillieres Clin Endocrinol Metab. 1995 Jan;9(1):157–174. doi: 10.1016/s0950-351x(95)80899-x. [DOI] [PubMed] [Google Scholar]
- Zhang X. Y., Wang X. M., Hu T. S. Profiling human leukocyte antigens in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1992 May 15;113(5):567–572. doi: 10.1016/s0002-9394(14)74731-2. [DOI] [PubMed] [Google Scholar]