Abstract
Nitric oxide has been determined to be a potential mediator of the haemodynamic changes associated with sepsis. The haemodynamic eects of nitric oxide can be partially antagonised by methylene blue, through inhibition of the enzyme, guanylate cyclase. The case report presented here demonstrates a beneficial haemodynamic eect of continuous infusion of methylene blue during sepsis. These findings could be extrapolated to other patients or prompt additional research.
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- Blass N., Fung D. Dyed but not dead--methylene blue overdose. Anesthesiology. 1976 Oct;45(4):458–459. doi: 10.1097/00000542-197610000-00020. [DOI] [PubMed] [Google Scholar]
- Burrows G. E. Methylene blue: effects and disposition in sheep. J Vet Pharmacol Ther. 1984 Sep;7(3):225–231. doi: 10.1111/j.1365-2885.1984.tb00904.x. [DOI] [PubMed] [Google Scholar]
- Culo F., Sabolović D., Somogyi L., Marusić M., Berbiguier N., Galey L. Anti-tumoral and anti-inflammatory effects of biological stains. Agents Actions. 1991 Nov;34(3-4):424–428. doi: 10.1007/BF01988739. [DOI] [PubMed] [Google Scholar]
- Daemen-Gubbels C. R., Groeneveld P. H., Groeneveld A. B., van Kamp G. J., Bronsveld W., Thijs L. G. Methylene blue increases myocardial function in septic shock. Crit Care Med. 1995 Aug;23(8):1363–1370. doi: 10.1097/00003246-199508000-00009. [DOI] [PubMed] [Google Scholar]
- Gruetter C. A., Kadowitz P. J., Ignarro L. J. Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite. Can J Physiol Pharmacol. 1981 Feb;59(2):150–156. doi: 10.1139/y81-025. [DOI] [PubMed] [Google Scholar]
- Johnstone M. T., Lam J. Y., Lacoste L., Baribeau J., Théroux P., Waters D. Methylene blue inhibits the antithrombotic effect of nitroglycerin. J Am Coll Cardiol. 1993 Jan;21(1):255–259. doi: 10.1016/0735-1097(93)90745-m. [DOI] [PubMed] [Google Scholar]
- Kilbourn R. G., Cromeens D. M., Chelly F. D., Griffith O. W. NG-methyl-L-arginine, an inhibitor of nitric oxide formation, acts synergistically with dobutamine to improve cardiovascular performance in endotoxemic dogs. Crit Care Med. 1994 Nov;22(11):1835–1840. [PubMed] [Google Scholar]
- Kilbourn R. G., Jubran A., Gross S. S., Griffith O. W., Levi R., Adams J., Lodato R. F. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun. 1990 Nov 15;172(3):1132–1138. doi: 10.1016/0006-291x(90)91565-a. [DOI] [PubMed] [Google Scholar]
- Lösche W., Bosia A., Heller R., Pescarmona G. P., Arese P., Till U. Methylene blue inhibits the arachidonic acid metabolism in human blood platelets. Biomed Biochim Acta. 1988;47(10-11):S100–S103. [PubMed] [Google Scholar]
- Preiser J. C., Lejeune P., Roman A., Carlier E., De Backer D., Leeman M., Kahn R. J., Vincent J. L. Methylene blue administration in septic shock: a clinical trial. Crit Care Med. 1995 Feb;23(2):259–264. doi: 10.1097/00003246-199502000-00010. [DOI] [PubMed] [Google Scholar]
- Schneider F., Lutun P., Hasselmann M., Stoclet J. C., Tempé J. D. Methylene blue increases systemic vascular resistance in human septic shock. Preliminary observations. Intensive Care Med. 1992;18(5):309–311. doi: 10.1007/BF01706481. [DOI] [PubMed] [Google Scholar]
- Sloand E. M., Kessler C. M., McIntosh C. L., Klein H. G. Methylene blue for neutralization of heparin. Thromb Res. 1989 Jun 15;54(6):677–686. doi: 10.1016/0049-3848(89)90132-1. [DOI] [PubMed] [Google Scholar]
- Torres M., Ceballos G., Rubio R. Possible role of nitric oxide in catecholamine secretion by chromaffin cells in the presence and absence of cultured endothelial cells. J Neurochem. 1994 Sep;63(3):988–996. doi: 10.1046/j.1471-4159.1994.63030988.x. [DOI] [PubMed] [Google Scholar]