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. 1996 Dec;72(854):719–724. doi: 10.1136/pgmj.72.854.719

Bladder cancer.

H Y Leung 1, T R Griffiths 1, D E Neal 1
PMCID: PMC2398659  PMID: 9015464

Abstract

Bladder cancer is the fourth most common cancer in England and Wales. The most common presenting symptom is macroscopic haematuria. The management options for superficial and invasive bladder cancer depend on the stage at presentation. Most superficial bladder cancers are managed by transurethral resection and cytoscopic follow-up. The prognosis for patients with invasive bladder cancer is less good. The role of chemical, radiotherapeutic and surgical intervention are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abel P. D., Hall R. R., Williams G. Should pT1 transitional cell cancers of the bladder still be classified as superficial? Br J Urol. 1988 Sep;62(3):235–239. doi: 10.1111/j.1464-410x.1988.tb04325.x. [DOI] [PubMed] [Google Scholar]
  2. Bloom H. J., Hendry W. F., Wallace D. M., Skeet R. G. Treatment of T3 bladder cancer: controlled trial of pre-operative radiotherapy and radical cystectomy versus radical radiotherapy. Br J Urol. 1982 Apr;54(2):136–151. doi: 10.1111/j.1464-410x.1982.tb13537.x. [DOI] [PubMed] [Google Scholar]
  3. Bouffioux C. Intravesical adjuvant treatment in superficial bladder cancer. A review of the question after 15 years of experience with the EORTC GU group. Scand J Urol Nephrol Suppl. 1991;138:167–177. [PubMed] [Google Scholar]
  4. Brendler C. B., Steinberg G. D., Marshall F. F., Mostwin J. L., Walsh P. C. Local recurrence and survival following nerve-sparing radical cystoprostatectomy. J Urol. 1990 Nov;144(5):1137–1141. doi: 10.1016/s0022-5347(17)39675-1. [DOI] [PubMed] [Google Scholar]
  5. Britton J. P. Effectiveness of haematuria clinics. Br J Urol. 1993 Mar;71(3):247–252. doi: 10.1111/j.1464-410x.1993.tb15936.x. [DOI] [PubMed] [Google Scholar]
  6. Burchill S. A., Neal D. E., Lunec J. Frequency of H-ras mutations in human bladder cancer detected by direct sequencing. Br J Urol. 1994 May;73(5):516–521. doi: 10.1111/j.1464-410x.1994.tb07636.x. [DOI] [PubMed] [Google Scholar]
  7. Daly A. K., Thomas D. J., Cooper J., Pearson W. R., Neal D. E., Idle J. R. Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. BMJ. 1993 Aug 21;307(6902):481–482. doi: 10.1136/bmj.307.6902.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Duncan W., Quilty P. M. The results of a series of 963 patients with transitional cell carcinoma of the urinary bladder primarily treated by radical megavoltage X-ray therapy. Radiother Oncol. 1986 Dec;7(4):299–310. doi: 10.1016/s0167-8140(86)80059-7. [DOI] [PubMed] [Google Scholar]
  9. Filmer R. B., Spencer J. R. Malignancies in bladder augmentations and intestinal conduits. J Urol. 1990 Apr;143(4):671–678. doi: 10.1016/s0022-5347(17)40055-3. [DOI] [PubMed] [Google Scholar]
  10. Greene L. F., Hanash K. A., Farrow G. M. Benign papilloma or papillary carcinoma of the bladder? J Urol. 1973 Aug;110(2):205–207. doi: 10.1016/s0022-5347(17)60161-7. [DOI] [PubMed] [Google Scholar]
  11. Hall R. R., Parmar M. K., Richards A. B., Smith P. H. Proposal for changes in cystoscopic follow up of patients with bladder cancer and adjuvant intravesical chemotherapy. BMJ. 1994 Jan 22;308(6923):257–260. doi: 10.1136/bmj.308.6923.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hautmann R. E., Egghart G., Frohneberg D., Miller K. The ileal neobladder. J Urol. 1988 Jan;139(1):39–42. doi: 10.1016/s0022-5347(17)42283-x. [DOI] [PubMed] [Google Scholar]
  13. Lamm D. L., van der Meijden P. M., Morales A., Brosman S. A., Catalona W. J., Herr H. W., Soloway M. S., Steg A., Debruyne F. M. Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer. J Urol. 1992 Mar;147(3):596–600. doi: 10.1016/s0022-5347(17)37316-0. [DOI] [PubMed] [Google Scholar]
  14. Lilien O. M., Camey M. 25-year experience with replacement of the human bladder (Camey procedure). J Urol. 1984 Nov;132(5):886–891. doi: 10.1016/s0022-5347(17)49934-4. [DOI] [PubMed] [Google Scholar]
  15. Loehrer P. J., Sr, Einhorn L. H., Elson P. J., Crawford E. D., Kuebler P., Tannock I., Raghavan D., Stuart-Harris R., Sarosdy M. F., Lowe B. A. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol. 1992 Jul;10(7):1066–1073. doi: 10.1200/JCO.1992.10.7.1066. [DOI] [PubMed] [Google Scholar]
  16. Lutzeyer W., Rübben H., Dahm H. Prognostic parameters in superficial bladder cancer: an analysis of 315 cases. J Urol. 1982 Feb;127(2):250–252. doi: 10.1016/s0022-5347(17)53725-8. [DOI] [PubMed] [Google Scholar]
  17. Malkowicz S. B., Nichols P., Lieskovsky G., Boyd S. D., Huffman J., Skinner D. G. The role of radical cystectomy in the management of high grade superficial bladder cancer (PA, P1, PIS and P2) J Urol. 1990 Sep;144(3):641–645. doi: 10.1016/s0022-5347(17)39544-7. [DOI] [PubMed] [Google Scholar]
  18. Montie J. E., Straffon R. A., Stewart B. H. Radical cystectomy without radiation therapy for carcinoma of the bladder. J Urol. 1984 Mar;131(3):477–482. doi: 10.1016/s0022-5347(17)50458-9. [DOI] [PubMed] [Google Scholar]
  19. Neal D. E., Sharples L., Smith K., Fennelly J., Hall R. R., Harris A. L. The epidermal growth factor receptor and the prognosis of bladder cancer. Cancer. 1990 Apr 1;65(7):1619–1625. doi: 10.1002/1097-0142(19900401)65:7<1619::aid-cncr2820650728>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  20. Oosterlinck W., Kurth K. H., Schröder F., Bultinck J., Hammond B., Sylvester R. A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized trial comparing transurethral resection followed by a single intravesical instillation of epirubicin or water in single stage Ta, T1 papillary carcinoma of the bladder. J Urol. 1993 Apr;149(4):749–752. doi: 10.1016/s0022-5347(17)36198-0. [DOI] [PubMed] [Google Scholar]
  21. Pagano F., Bassi P., Galetti T. P., Meneghini A., Milani C., Artibani W., Garbeglio A. Results of contemporary radical cystectomy for invasive bladder cancer: a clinicopathological study with an emphasis on the inadequacy of the tumor, nodes and metastases classification. J Urol. 1991 Jan;145(1):45–50. doi: 10.1016/s0022-5347(17)38244-7. [DOI] [PubMed] [Google Scholar]
  22. Parmar M. K., Freedman L. S., Hargreave T. B., Tolley D. A. Prognostic factors for recurrence and followup policies in the treatment of superficial bladder cancer: report from the British Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party). J Urol. 1989 Aug;142(2 Pt 1):284–288. doi: 10.1016/s0022-5347(17)38731-1. [DOI] [PubMed] [Google Scholar]
  23. Presti J. C., Jr, Reuter V. E., Galan T., Fair W. R., Cordon-Cardo C. Molecular genetic alterations in superficial and locally advanced human bladder cancer. Cancer Res. 1991 Oct 1;51(19):5405–5409. [PubMed] [Google Scholar]
  24. Shipley W. U. Review of factors predicting improved tumor control and survival from invasive bladder carcinoma following external beam radiation therapy. Prog Clin Biol Res. 1988;260:437–446. [PubMed] [Google Scholar]
  25. Skinner D. G., Daniels J. R., Russell C. A., Lieskovsky G., Boyd S. D., Nichols P., Kern W., Sakamoto J., Krailo M., Groshen S. The role of adjuvant chemotherapy following cystectomy for invasive bladder cancer: a prospective comparative trial. J Urol. 1991 Mar;145(3):459–467. doi: 10.1016/s0022-5347(17)38368-4. [DOI] [PubMed] [Google Scholar]
  26. Skinner D. G., Lieskovsky G. Contemporary cystectomy with pelvic node dissection compared to preoperative radiation therapy plus cystectomy in management of invasive bladder cancer. J Urol. 1984 Jun;131(6):1069–1072. doi: 10.1016/s0022-5347(17)50809-5. [DOI] [PubMed] [Google Scholar]
  27. Skinner E. C., Lieskovsky G., Skinner D. G. Radical cystectomy in the elderly patient. J Urol. 1984 Jun;131(6):1065–1068. doi: 10.1016/s0022-5347(17)50808-3. [DOI] [PubMed] [Google Scholar]
  28. Steiner M. S., Morton R. A., Marshall F. F. Vitamin B12 deficiency in patients with ileocolic neobladders. J Urol. 1993 Feb;149(2):255–257. doi: 10.1016/s0022-5347(17)36049-4. [DOI] [PubMed] [Google Scholar]
  29. Sternberg C. N., Yagoda A., Scher H. I., Watson R. C., Ahmed T., Weiselberg L. R., Geller N., Hollander P. S., Herr H. W., Sogani P. C. Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol. 1985 Mar;133(3):403–407. doi: 10.1016/s0022-5347(17)48996-8. [DOI] [PubMed] [Google Scholar]
  30. Tolley D. A., Hargreave T. B., Smith P. H., Williams J. L., Grigor K. M., Parmar M. K., Freedman L. S., Uscinska B. M. Effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: interim report from the Medical Research Council Subgroup on Superficial Bladder Cancer (Urological Cancer Working Party). Br Med J (Clin Res Ed) 1988 Jun 25;296(6639):1759–1761. doi: 10.1136/bmj.296.6639.1759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Utz D. C., Hanash K. A., Farrow G. M. The plight of the patient with carcinoma in situ of the bladder. J Urol. 1970 Feb;103(2):160–164. doi: 10.1016/s0022-5347(17)61913-x. [DOI] [PubMed] [Google Scholar]
  32. Wright C., Mellon K., Johnston P., Lane D. P., Harris A. L., Horne C. H., Neal D. E. Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder. Br J Cancer. 1991 Jun;63(6):967–970. doi: 10.1038/bjc.1991.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Wright C., Thomas D., Mellon K., Neal D. E., Horne C. H. Expression of retinoblastoma gene product and p53 protein in bladder carcinoma: correlation with Ki67 index. Br J Urol. 1995 Feb;75(2):173–179. doi: 10.1111/j.1464-410x.1995.tb07306.x. [DOI] [PubMed] [Google Scholar]

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