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. 1991 Apr;67(786):358–361. doi: 10.1136/pgmj.67.786.358

Prevalence of anticardiolipin antibodies in the elderly British population.

K K Chakravarty 1, R E Gray 1, M Webley 1, M A Byron 1, J Wozniak 1
PMCID: PMC2398833  PMID: 2068029

Abstract

In a cross-sectional study of 100 healthy elderly individuals, anticardiolipin antibodies (aCL) were measured using an ELISA technique. aCL were not detected in the majority of subjects (63%), and in the remaining 37% titres were within the laboratory reference range (mean +5 standard deviations) previously determined for adults of all ages. In contrast, significant titres of IgM rheumatoid factor were found in 10%, antimitochondrial antibody in 13%, antinuclear factor in 5%, anti-smooth muscle antibody in 18%, antiparietal cell antibody in 10%, and antireticulin antibody in 1%. Antibodies to single or double-stranded DNA were not detected in any subject. We conclude that, although other auto-antibodies may be present in the healthy aging population in Britain, abnormally elevated levels of aCL antibody do not occur, and when present may be an indicator of autoimmune-mediated pathology.

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Selected References

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  1. Alarcón-Segovia D., Sanchez-Guerrero J. Primary antiphospholipid syndrome. J Rheumatol. 1989 Apr;16(4):482–488. [PubMed] [Google Scholar]
  2. Asherson R. A., Derksen R. H., Harris E. N., Bingley P. J., Hoffbrand B. I., Gharavi A. E., Kater L., Hughes G. R. Large vessel occlusion and gangrene in systemic lupus erythematosus and "lupus-like" disease. A report of six cases. J Rheumatol. 1986 Aug;13(4):740–747. [PubMed] [Google Scholar]
  3. Asherson R. A., Harris E. N. Anticardiolipin antibodies--clinical associations. Postgrad Med J. 1986 Dec;62(734):1081–1087. doi: 10.1136/pgmj.62.734.1081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Asherson R. A., Khamashta M. A., Ordi-Ros J., Derksen R. H., Machin S. J., Barquinero J., Outt H. H., Harris E. N., Vilardell-Torres M., Hughes G. R. The "primary" antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore) 1989 Nov;68(6):366–374. [PubMed] [Google Scholar]
  5. Asherson R. A., Mercey D., Phillips G., Sheehan N., Gharavi A. E., Harris E. N., Hughes G. R. Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis. 1987 Aug;46(8):605–611. doi: 10.1136/ard.46.8.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Boey M. L., Colaco C. B., Gharavi A. E., Elkon K. B., Loizou S., Hughes G. R. Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 8;287(6398):1021–1023. doi: 10.1136/bmj.287.6398.1021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bouchez B., Arnott G., Hatron P. Y., Wattel A., Devulder B. Chorée et lupus érythémateux disséminé avec anticoagulant circulant. Trois cas. Rev Neurol (Paris) 1985;141(8-9):571–577. [PubMed] [Google Scholar]
  8. Colaço C. B., Scadding G. K., Lockhart S. Anti-cardiolipin antibodies in neurological disorders: cross-reaction with anti-single stranded DNA activity. Clin Exp Immunol. 1987 May;68(2):313–319. [PMC free article] [PubMed] [Google Scholar]
  9. Gastineau D. A., Kazmier F. J., Nichols W. L., Bowie E. J. Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases. Am J Hematol. 1985 Jul;19(3):265–275. doi: 10.1002/ajh.2830190308. [DOI] [PubMed] [Google Scholar]
  10. Glueck H. I., Kant K. S., Weiss M. A., Pollak V. E., Miller M. A., Coots M. Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med. 1985 Aug;145(8):1389–1395. [PubMed] [Google Scholar]
  11. Harris E. N., Gharavi A. E., Asherson R. A., Boey M. L., Hughes G. R. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol. 1984 Jan-Mar;2(1):47–51. [PubMed] [Google Scholar]
  12. Harris E. N., Gharavi A. E., Boey M. L., Patel B. M., Mackworth-Young C. G., Loizou S., Hughes G. R. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet. 1983 Nov 26;2(8361):1211–1214. doi: 10.1016/s0140-6736(83)91267-9. [DOI] [PubMed] [Google Scholar]
  13. Harris E. N., Gharavi A. E., Hughes G. R. Anti-phospholipid antibodies. Clin Rheum Dis. 1985 Dec;11(3):591–609. [PubMed] [Google Scholar]
  14. Hughes G. R. An immune mechanism in thrombosis. Q J Med. 1988 Oct;68(258):753–754. [PubMed] [Google Scholar]
  15. Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
  16. Hughes G. R. The Prosser-White oration 1983. Connective tissue disease and the skin. Clin Exp Dermatol. 1984 Nov;9(6):535–544. doi: 10.1111/j.1365-2230.1984.tb00856.x. [DOI] [PubMed] [Google Scholar]
  17. Hughes G. R. Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 15;287(6399):1088–1089. doi: 10.1136/bmj.287.6399.1088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hull R. G., Harris E. N., Gharavi A. E., Tincani A., Asherson R. A., Valesini G., Denman A. M., Froude G., Hughes G. R. Anticardiolipin antibodies: occurrence in Behçet's syndrome. Ann Rheum Dis. 1984 Oct;43(5):746–748. doi: 10.1136/ard.43.5.746. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Levine S. R., Welch K. M. Cerebrovascular ischemia associated with lupus anticoagulant. Stroke. 1987 Jan-Feb;18(1):257–263. doi: 10.1161/01.str.18.1.257. [DOI] [PubMed] [Google Scholar]
  20. Loizou S., McCrea J. D., Rudge A. C., Reynolds R., Boyle C. C., Harris E. N. Measurement of anti-cardiolipin antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol. 1985 Dec;62(3):738–745. [PMC free article] [PubMed] [Google Scholar]
  21. Mackworth-Young C. G., Loizou S., Walport M. J. Primary antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorder. Ann Rheum Dis. 1989 May;48(5):362–367. doi: 10.1136/ard.48.5.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mackworth-Young C. G., Melia W. M., Harris E. N., Gharavi A. E., Sivathondan Y., Derue G., Sherlock S., Hughes G. R. The Budd-Chiari syndrome. Possible pathogenetic role of anti-phospholipid antibodies. J Hepatol. 1986;3(1):83–86. doi: 10.1016/s0168-8278(86)80150-7. [DOI] [PubMed] [Google Scholar]
  23. Manoussakis M. N., Tzioufas A. G., Silis M. P., Pange P. J., Goudevenos J., Moutsopoulos H. M. High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin Exp Immunol. 1987 Sep;69(3):557–565. [PMC free article] [PubMed] [Google Scholar]

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