Abstract
Twenty-five patients with squamous cell carcinoma (SCC) of the anus have presented over an 8 year period; 18 were female. Six of 9 patients aged under 50 years were female. Five of these women had been treated for a previous cervical malignancy (2 invasive) and 4 practised anal intercourse; human papillomavirus (HPV) type 16 DNAs were isolated from their arcival anal/cervical paraffin sections. Signals were confined to the nuclei of the invasive anal SCC cells and the transformation zone of the cervix. HPV 6, 11 and 18 DNAs were not identified. Young women with cervical intraepithelial (CIN) III or invasive cervical SCC found in association with HPV infection are at risk of developing anal SCC (P less than 0.001; Fisher's exact).
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Selected References
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- Austin D. F. Etiological clues from descriptive epidemiology: squamous carcinoma of the rectum or anus. Natl Cancer Inst Monogr. 1982;62:89–90. [PubMed] [Google Scholar]
- Cooper H. S., Patchefsky A. S., Marks G. Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. Dis Colon Rectum. 1979 Nov-Dec;22(8):557–558. doi: 10.1007/BF02587005. [DOI] [PubMed] [Google Scholar]
- McCance D. J., Clarkson P. K., Dyson J. L., Walker P. G., Singer A. Human papillomavirus types 6 and 16 in multifocal intraepithelial neoplasias of the female lower genital tract. Br J Obstet Gynaecol. 1985 Nov;92(11):1093–1100. doi: 10.1111/j.1471-0528.1985.tb03018.x. [DOI] [PubMed] [Google Scholar]
- Palmer J. G., Shepherd N. A., Jass J. R., Crawford L. V., Northover J. M. Human papillomavirus type 16 DNA in anal squamous cell carcinoma. Lancet. 1987 Jul 4;2(8549):42–42. doi: 10.1016/s0140-6736(87)93075-3. [DOI] [PubMed] [Google Scholar]
- Pringle J. H., Homer C. E., Warford A., Kendall C. H., Lauder I. In situ hybridization: alkaline phosphatase visualization of biotinylated probes in cryostat and paraffin sections. Histochem J. 1987 Sep;19(9):488–496. doi: 10.1007/BF01675419. [DOI] [PubMed] [Google Scholar]
- Reid R., Stanhope C. R., Herschman B. R., Booth E., Phibbs G. D., Smith J. P. Genital warts and cervical cancer. I. Evidence of an association between subclinical papillomavirus infection and cervical malignancy. Cancer. 1982 Jul 15;50(2):377–387. doi: 10.1002/1097-0142(19820715)50:2<377::aid-cncr2820500236>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Scholefield J. H., Sonnex C., Talbot I. C., Palmer J. G., Whatrup C., Mindel A., Northover J. M. Anal and cervical intraepithelial neoplasia: possible parallel. Lancet. 1989 Sep 30;2(8666):765–769. doi: 10.1016/s0140-6736(89)90830-1. [DOI] [PubMed] [Google Scholar]