Abstract
A 31 year old man first developed steroid-resistant idiopathic membranous glomerulonephritis in 1981. Stable normal renal function was maintained until August 1988 when he suffered a clinical relapse with heavy proteinuria and declining renal function. Immunosuppressive therapy with prednisolone and cyclophosphamide was instituted in an attempt to arrest this relapse. Despite this, he later developed acute renal failure with histological evidence of crescentic transformation of his nephritis. This unusual transformation was not associated with features of systemic vasculitis or positive anti-glomerular basement membrane and anti-neutrophil cytoplasmic antibodies.
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- Abreo K., Abreo F., Mitchell B., Schloemer G. Idiopathic crescentic membranous glomerulonephritis. Am J Kidney Dis. 1986 Oct;8(4):257–261. doi: 10.1016/s0272-6386(86)80036-1. [DOI] [PubMed] [Google Scholar]
- Beregi E., Varga I. Analysis of 260 cases of membranous glomerulonephritis in renal biopsy material. Clin Nephrol. 1974 Nov-Dec;2(6):215–221. [PubMed] [Google Scholar]
- Hill G. S., Robertson J., Grossman R., Perloff L., Barker C. F. An unusual variant of membranous nephropathy with abundant crescent formation and recurrence in the transplanted kidney. Clin Nephrol. 1978 Sep;10(3):114–120. [PubMed] [Google Scholar]
- Klassen J., Elwood C., Grossberg A. L., Milgrom F., Montes M., Sepulveda M., Andres G. A. Evolution of membranous nephropathy into anti-glomerular-basement-membrane glomerulonephritis. N Engl J Med. 1974 Jun 13;290(24):1340–1344. doi: 10.1056/NEJM197406132902403. [DOI] [PubMed] [Google Scholar]
- Kurki P., Helve T., von Bonsdorff M., Törnroth T., Pettersson E., Riska H., Miettinen A. Transformation of membranous glomerulonephritis into crescentic glomerulonephritis with glomerular basement membrane antibodies. Serial determinations of anti-GBM before the transformation. Nephron. 1984;38(2):134–137. doi: 10.1159/000183294. [DOI] [PubMed] [Google Scholar]
- Lockwood C. M., Peters D. K. Plasma exchange in glomerulonephritis and related vasculitides. Annu Rev Med. 1980;31:167–179. doi: 10.1146/annurev.me.31.020180.001123. [DOI] [PubMed] [Google Scholar]
- Mathieson P. W., Turner A. N., Maidment C. G., Evans D. J., Rees A. J. Prednisolone and chlorambucil treatment in idiopathic membranous nephropathy with deteriorating renal function. Lancet. 1988 Oct 15;2(8616):869–872. doi: 10.1016/s0140-6736(88)92470-1. [DOI] [PubMed] [Google Scholar]
- Moorthy A. V., Zimmerman S. W., Burkholder P. M., Harrington A. R. Association of crescentic glomerulonephritis with membranous glomerulonephropathy: a report of three cases. Clin Nephrol. 1976 Jul;6(1):319–325. [PubMed] [Google Scholar]
- Nguyen B. P., Reisin E., Rodriguez F. H., Jr Idiopathic membranous glomerulopathy complicated by crescentic glomerulonephritis and renal vein thrombosis. Am J Kidney Dis. 1988 Oct;12(4):326–328. doi: 10.1016/s0272-6386(88)80229-4. [DOI] [PubMed] [Google Scholar]
- Nicholson G. D., Amin U. F., Alleyne G. A. Membranous glomerulonephropathy with crescents. Clin Nephrol. 1975 Nov;4(5):198–201. [PubMed] [Google Scholar]
- Ponticelli C., Zucchelli P., Passerini P., Cagnoli L., Cesana B., Pozzi C., Pasquali S., Imbasciati E., Grassi C., Redaelli B. A randomized trial of methylprednisolone and chlorambucil in idiopathic membranous nephropathy. N Engl J Med. 1989 Jan 5;320(1):8–13. doi: 10.1056/NEJM198901053200102. [DOI] [PubMed] [Google Scholar]
- West M. L., Jindal K. K., Bear R. A., Goldstein M. B. A controlled trial of cyclophosphamide in patients with membranous glomerulonephritis. Kidney Int. 1987 Oct;32(4):579–584. doi: 10.1038/ki.1987.247. [DOI] [PubMed] [Google Scholar]