Skip to main content
PMC home page
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1991 Jan;67(783):42–46. doi: 10.1136/pgmj.67.783.42

The accuracy of creatinine clearance with and without urine collection as a measure of glomerular filtration rate.

D G Waller 1, J S Fleming 1, B Ramsey 1, J Gray 1
PMCID: PMC2398953  PMID: 2057426

Abstract

Conventional creatinine clearances involving urine collections over 2, 4 and 24 hours and creatinine clearance predicted from plasma creatinine concentrations without urine collection were compared to glomerular filtration rate (GFR) estimated by 99mTc DTPA clearance in 171 patients with a wide range of GFR. All creatinine clearance methods involving urine collection had standard errors of the estimate of GFR greater than predictions from formulae. Predictions of creatinine clearance by formulae had coefficients of variation of the estimate of approximately 23% when compared to isotopically determined GFR. Creatinine clearances determined by these equations in patients with stable renal function are an easier and at least as accurate a guide to GFR as methods involving urine collection.

Full text

PDF
42

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjornsson T. D., Cocchetto D. M., McGowan F. X., Verghese C. P., Sedor F. Nomogram for estimating creatinine clearance. Clin Pharmacokinet. 1983 Jul-Aug;8(4):365–369. doi: 10.2165/00003088-198308040-00007. [DOI] [PubMed] [Google Scholar]
  2. Bjornsson T. D. Use of serum creatinine concentrations to determine renal function. Clin Pharmacokinet. 1979 May-Jun;4(3):200–222. doi: 10.2165/00003088-197904030-00003. [DOI] [PubMed] [Google Scholar]
  3. Brochner-Mortensen J., Jensen S., Rodbro P. Assessment of renal function from plasma creatinine in adult patients. Scand J Urol Nephrol. 1977;11(3):263–270. doi: 10.3109/00365597709179963. [DOI] [PubMed] [Google Scholar]
  4. Bröchner-Mortensen J., Rödbro P. Selection of routine method for determination of glomerular filtration rate in adult patients. Scand J Clin Lab Invest. 1976 Jan;36(1):35–43. doi: 10.1080/00365517609068016. [DOI] [PubMed] [Google Scholar]
  5. Brøchner-Mortensen J. Routine methods and their reliability for assessment of glomerular filtration rate in adults, with special reference to total [51Cr]EDTA plasma clearance. Dan Med Bull. 1978 Oct;25(5):181–202. [PubMed] [Google Scholar]
  6. Charleson H. A., Bailey R. R., Stewart A. Quick prediction of creatinine clearance without the necessity of urine collection. N Z Med J. 1980 Dec 10;92(673):425–426. [PubMed] [Google Scholar]
  7. Cocchetto D. M., Tschanz C., Bjornsson T. D. Decreased rate of creatinine production in patients with hepatic disease: implications for estimation of creatinine clearance. Ther Drug Monit. 1983 Jun;5(2):161–168. doi: 10.1097/00007691-198306000-00002. [DOI] [PubMed] [Google Scholar]
  8. Cockcroft D. W., Gault M. H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41. doi: 10.1159/000180580. [DOI] [PubMed] [Google Scholar]
  9. Groth S., Aasted M., Vestergaard B. Screening of kidney function by plasma creatinine and single-sample 51Cr-EDTA clearance determination--a comparison. Scand J Clin Lab Invest. 1989 Dec;49(8):707–710. doi: 10.3109/00365518909091548. [DOI] [PubMed] [Google Scholar]
  10. Hagstam K. E., Nordenfelt I., Svensson L., Svensson S. E. Comparison of different methods for determination of glomerular filtration rate in renal disease. Scand J Clin Lab Invest. 1974 Sep;34(1):31–36. doi: 10.3109/00365517409061818. [DOI] [PubMed] [Google Scholar]
  11. Heierli C., Thölen H., Bartels H. Schätzung des Glomerulumfiltrats furch das Serum-Kreatinin. Dtsch Med Wochenschr. 1972 Jan 21;97(3):67–70. doi: 10.1055/s-0028-1107301. [DOI] [PubMed] [Google Scholar]
  12. Hull J. H., Hak L. J., Koch G. G., Wargin W. A., Chi S. L., Mattocks A. M. Influence of range of renal function and liver disease on predictability of creatinine clearance. Clin Pharmacol Ther. 1981 Apr;29(4):516–521. doi: 10.1038/clpt.1981.72. [DOI] [PubMed] [Google Scholar]
  13. MILLER B. F., LEAF A., MAMBY A. R., MILLER Z. Validity of the endogenous creatinine clearance as a measure of glomerular filtration rate in the diseased human kidney. J Clin Invest. 1952 Mar;31(3):309–313. doi: 10.1172/JCI102607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rehling M., Møller M. L., Thamdrup B., Lund J. O., Trap-Jensen J. Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepenta-acetate, 51Cr-labelled ethylenediaminetetra-acetate and inulin in man. Clin Sci (Lond) 1984 May;66(5):613–619. doi: 10.1042/cs0660613. [DOI] [PubMed] [Google Scholar]
  15. Richardson J. A., Philbin P. E. The one-hour creatinine clearance rate in healthy men. JAMA. 1971 May 10;216(6):987–990. [PubMed] [Google Scholar]
  16. Rolin H. A., 3rd, Hall P. M., Wei R. Inaccuracy of estimated creatinine clearance for prediction of iothalamate glomerular filtration rate. Am J Kidney Dis. 1984 Jul;4(1):48–54. doi: 10.1016/s0272-6386(84)80026-8. [DOI] [PubMed] [Google Scholar]
  17. Smith S. A. Estimation of glomerular filtration rate from the serum creatinine concentration. Postgrad Med J. 1988 Mar;64(749):204–208. doi: 10.1136/pgmj.64.749.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Trollfors B., Alestig K., Jagenburg R. Prediction of glomerular filtration rate from serum creatinine, age, sex and body weight. Acta Med Scand. 1987;221(5):495–498. doi: 10.1111/j.0954-6820.1987.tb01286.x. [DOI] [PubMed] [Google Scholar]
  19. Waller D. G., Keast C. M., Fleming J. S., Ackery D. M. Measurement of glomerular filtration rate with technetium-99m DTPA: comparison of plasma clearance techniques. J Nucl Med. 1987 Mar;28(3):372–377. [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES