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. 1992 Jan;68(795):41–43. doi: 10.1136/pgmj.68.795.41

Mania in association with hydrocortisone replacement for Addison's disease.

E Ur 1, T H Turner 1, T J Goodwin 1, A Grossman 1, G M Besser 1
PMCID: PMC2399305  PMID: 1561189

Abstract

A 32 year old woman with untreated primary adenocortical insufficiency presented with prominent depressive symptoms. Upon treatment with physiological doses of glucocorticoids she developed a self-limiting acute manic illness. We suggest that up-regulation of hippocampal glucocorticoid receptors as a consequence of prolonged hypocortisolaemia resulted in increased cerebral sensitivity to exogenous corticosteroids, which are known to precipitate manic symptoms in some normal individuals when given in supraphysiological doses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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