Abstract
Patient preference for intravenous or subcutaneous heparin in the treatment of deep venous thrombosis was assessed in a randomized cross-over study. Twenty patients with venographically proven deep venous thrombosis were randomized to receive subcutaneous or intravenous heparin for 3 days followed by 3 days of the other treatment. Discomfort at the injection site, assessed by visual analogue scale, was significantly less for the subcutaneous than the intravenous administration route (P < 0.001), mobility was thought to be better when receiving subcutaneous heparin (P < 0.005) and patients' overall preference was for subcutaneous treatment (P < 0.001).
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Andersson G., Fagrell B., Holmgren K., Johnsson H., Ljungberg B., Nilsson E., Wilhelmsson S., Zetterquist S. Subcutaneous administration of heparin. A randomised comparison with intravenous administration of heparin to patients with deep-vein thrombosis. Thromb Res. 1982 Sep 15;27(6):631–639. doi: 10.1016/0049-3848(82)90001-9. [DOI] [PubMed] [Google Scholar]
- Bentley P. G., Kakkar V. V., Scully M. F., MacGregor I. R., Webb P., Chan P., Jones N. An objective study of alternative methods of heparin administration. Thromb Res. 1980 Apr 1;18(1-2):177–187. doi: 10.1016/0049-3848(80)90182-6. [DOI] [PubMed] [Google Scholar]
- Doyle D. J., Turpie A. G., Hirsh J., Best C., Kinch D., Levine M. N., Gent M. Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis. A randomized trial. Ann Intern Med. 1987 Oct;107(4):441–445. doi: 10.7326/0003-4819-107-4-441. [DOI] [PubMed] [Google Scholar]
- Hommes D. W., Bura A., Mazzolai L., Büller H. R., ten Cate J. W. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. A meta-analysis. Ann Intern Med. 1992 Feb 15;116(4):279–284. doi: 10.7326/0003-4819-116-4-279. [DOI] [PubMed] [Google Scholar]
- Walker M. G., Shaw J. W., Thomson G. J., Cumming J. G., Thomas M. L. Subcutaneous calcium heparin versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: a multicentre prospective randomised trial. Br Med J (Clin Res Ed) 1987 May 9;294(6581):1189–1192. doi: 10.1136/bmj.294.6581.1189. [DOI] [PMC free article] [PubMed] [Google Scholar]