Skip to main content
Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 1993 Aug;69(814):656–658. doi: 10.1136/pgmj.69.814.656

Sclerosing cholangitis associated with Crohn's disease and autoimmune haemolytic anaemia.

O Eilam 1, E Goldin 1, D Shouval 1, T Gimon 1, C Brautbar 1
PMCID: PMC2399701  PMID: 8234117

Abstract

A middle-aged man was found to have autoimmune haemolytic anaemia. Seven years after the first manifestations of the anaemia, he developed jaundice without haemolysis and a diagnosis of primary sclerosing cholangitis was made by endoscopic retrograde cholangiography. Crohn's colitis was later confirmed by X-rays and colonoscopy. This association is unique to the best of our knowledge and suggests that genetic and immunological mechanisms may be involved in the pathogenesis of these diseases.

Full text

PDF
656

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Airoldi M., Giornazzi L., Rosetta A., Stefanetti C. Anticorpi antieritrocitari con e senza emolisi nella colite ulcerosa. Presentazione di due casi. Recenti Prog Med. 1986 Nov;77(11):527–529. [PubMed] [Google Scholar]
  2. Altman A. R., Maltz C., Janowitz H. D. Autoimmune hemolytic anemia in ulcerative colitis: report of three cases, review of the literature, and evaluation of modes of therapy. Dig Dis Sci. 1979 Apr;24(4):282–285. doi: 10.1007/BF01296541. [DOI] [PubMed] [Google Scholar]
  3. Aresu G., Miescher P. A., Mereu S., Pascalis L., Pia G. L'associazione ciclosporina A-fluocortolone nella terapia della rettocolite ulcerosa. Valutazione degli effetti benefici osservati in un caso complicato da grave anemia immunoemolitica. Clin Ter. 1987 Aug 15;122(3):163–170. [PubMed] [Google Scholar]
  4. Arner O., Brohult J., Engstedt L., Karlson R., Sällström T. Autoimmune hemolytic anemia in ulcerative colitis, cured by colectomy. Report of a case. Acta Med Scand. 1971 Apr;189(4):275–277. doi: 10.1111/j.0954-6820.1971.tb04375.x. [DOI] [PubMed] [Google Scholar]
  5. Bardana E. J., Jr, Pirofsky B. Autoimmune hemolytic anemia and ulcerative colitis: a multisystem immunodeficiency disease? Int Arch Allergy Appl Immunol. 1970;37(3):325–336. doi: 10.1159/000230794. [DOI] [PubMed] [Google Scholar]
  6. Basista M. H., Roe D. C. A case presentation of hemolytic anemia in ulcerative colitis and review of the literature. Am J Gastroenterol. 1986 Oct;81(10):990–992. [PubMed] [Google Scholar]
  7. Chapman R. W., Arborgh B. A., Rhodes J. M., Summerfield J. A., Dick R., Scheuer P. J., Sherlock S. Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut. 1980 Oct;21(10):870–877. doi: 10.1136/gut.21.10.870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goldstone A. H. Letter: Autoimmune haemolytic anaemia in ulcerative colitis. Br Med J. 1974 Jun 8;2(5918):556–556. doi: 10.1136/bmj.2.5918.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gorst D. W., Leyland M. J., Delamore I. W. Autoimmune haemolytic anaemia and ulcerative colitis. Postgrad Med J. 1975 Jun;51(596):409–411. doi: 10.1136/pgmj.51.596.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Helzberg J. H., Petersen J. M., Boyer J. L. Improved survival with primary sclerosing cholangitis. A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology. 1987 Jun;92(6):1869–1875. doi: 10.1016/0016-5085(87)90618-4. [DOI] [PubMed] [Google Scholar]
  11. Keene W. R. Uncommon abnormalities of blood associated with chronic ulcerative colitis. Med Clin North Am. 1966 Mar;50(2):535–541. [PubMed] [Google Scholar]
  12. Lang B., Weber S., Maas D. Die autoimmunhämolytische Anämie bei Colitis ulcerosa. Bericht über 7 Fälle, mögliche Behandlung und Literaturübersicht. Schweiz Med Wochenschr. 1985 Jun 29;115(26):897–902. [PubMed] [Google Scholar]
  13. Lillemoe K. D., Pitt H. A., Cameron J. L. Sclerosing cholangitis. Adv Surg. 1988;21:65–92. [PubMed] [Google Scholar]
  14. Moeller D. D. Sclerosing cholangitis associated with autoimmune hemolytic anemia and hyperthyroidism. Am J Gastroenterol. 1985 Feb;80(2):122–125. [PubMed] [Google Scholar]
  15. Ormerod T. P. Observations on the incidence and cause of anaemia in ulcerative colitis. Gut. 1967 Apr;8(2):107–114. doi: 10.1136/gut.8.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Poulsen L. O., Freund L., Lylloff K., Grunnet N. Positive Coombs' test associated with ulcerative colitis. A prevalence study. Acta Med Scand. 1988;223(1):75–78. doi: 10.1111/j.0954-6820.1988.tb15767.x. [DOI] [PubMed] [Google Scholar]
  17. Prochazka E. J., Terasaki P. I., Park M. S., Goldstein L. I., Busuttil R. W. Association of primary sclerosing cholangitis with HLA-DRw52a. N Engl J Med. 1990 Jun 28;322(26):1842–1844. doi: 10.1056/NEJM199006283222603. [DOI] [PubMed] [Google Scholar]
  18. Raya Muñoz J., Díez Ruiz A., Bonetti A., Bermúdez García J. M., Salmerón Escobar J., Soto Mas J., Peña Yañez A. Colitis ulcerosa asociada a anemia hemolítica autoinmune, trombosis arterial y necrosis dérmica. Rev Esp Enferm Apar Dig. 1983 Nov;64(5):435–440. [PubMed] [Google Scholar]
  19. Schrumpf E., Fausa O., Førre O., Dobloug J. H., Ritland S., Thorsby E. HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease. Scand J Gastroenterol. 1982 Mar;17(2):187–191. doi: 10.3109/00365528209182038. [DOI] [PubMed] [Google Scholar]
  20. Thomas M., Homberg J. C., Huguet C., Ricordeau P. Anemie hemolytique auto-immune au cours d'une rectocolite hemorragique. Guerison par proctectomie. Nouv Presse Med. 1972 Nov 25;1(42):2825–2825. [PubMed] [Google Scholar]
  21. Wiesner R. H., LaRusso N. F., Ludwig J., Dickson E. R. Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology. 1985 Jan;88(1 Pt 1):108–114. doi: 10.1016/s0016-5085(85)80141-4. [DOI] [PubMed] [Google Scholar]
  22. Wodzinski M. A., Lawrence A. C. Severe Coombs positive autoimmune haemolytic anaemia associated with ulcerative colitis. Postgrad Med J. 1985 Mar;61(713):261–262. doi: 10.1136/pgmj.61.713.261. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Postgraduate Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES