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. 1993 Sep;69(815):748–750. doi: 10.1136/pgmj.69.815.748

Is clubbing a feature of the anti-phospholipid antibody syndrome?

A W Harris 1, T A Harding 1, M D Gaitonde 1, J D Maxwell 1
PMCID: PMC2399783  PMID: 8255851

Abstract

A patient with the anti-phospholipid antibody syndrome and digital clubbing is described. No recognized cause for the clubbing was found. It is suggested that platelet aggregation and microthrombi formation as a result of anti-phospholipid antibody may be involved in the pathogenesis of the digital clubbing. This may be a new feature of the anti-phospholipid antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alegre V. A., Gastineau D. A., Winkelmann R. K. Skin lesions associated with circulating lupus anticoagulant. Br J Dermatol. 1989 Mar;120(3):419–429. doi: 10.1111/j.1365-2133.1989.tb04170.x. [DOI] [PubMed] [Google Scholar]
  2. Canoso R. T., Sise H. S. Chlorpromazine-induced lupus anticoagulant and associated immunologic abnormalities. Am J Hematol. 1982 Sep;13(2):121–129. doi: 10.1002/ajh.2830130204. [DOI] [PubMed] [Google Scholar]
  3. Dickinson C. J., Martin J. F. Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet. 1987 Dec 19;2(8573):1434–1435. doi: 10.1016/s0140-6736(87)91132-9. [DOI] [PubMed] [Google Scholar]
  4. Elias M., Eldor A. Thromboembolism in patients with the 'lupus'-type circulating anticoagulant. Arch Intern Med. 1984 Mar;144(3):510–515. [PubMed] [Google Scholar]
  5. Fox S. B., Day C. A., Gatter K. C. Association between platelet microthrombi and finger clubbing. Lancet. 1991 Aug 3;338(8762):313–314. doi: 10.1016/0140-6736(91)90452-u. [DOI] [PubMed] [Google Scholar]
  6. Galve E., Ordi J., Barquinero J., Evangelista A., Vilardell M., Soler-Soler J. Valvular heart disease in the primary antiphospholipid syndrome. Ann Intern Med. 1992 Feb 15;116(4):293–298. doi: 10.7326/0003-4819-116-4-293. [DOI] [PubMed] [Google Scholar]
  7. Harris E. N., Asherson R. A., Gharavi A. E., Morgan S. H., Derue G., Hughes G. R. Thrombocytopenia in SLE and related autoimmune disorders: association with anticardiolipin antibody. Br J Haematol. 1985 Feb;59(2):227–230. doi: 10.1111/j.1365-2141.1985.tb02988.x. [DOI] [PubMed] [Google Scholar]
  8. Hughes G. R., Harris N. N., Gharavi A. E. The anticardiolipin syndrome. J Rheumatol. 1986 Jun;13(3):486–489. [PubMed] [Google Scholar]
  9. Hughes G. R. Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br Med J (Clin Res Ed) 1983 Oct 15;287(6399):1088–1089. doi: 10.1136/bmj.287.6399.1088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wiener H. M., Vardinon N., Yust I. Platelet antibody binding and spontaneous aggregation in 21 lupus anticoagulant patients. Vox Sang. 1991;61(2):111–121. doi: 10.1111/j.1423-0410.1991.tb00256.x. [DOI] [PubMed] [Google Scholar]

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