Abstract
Invasive aspergillosis is a disease of the immunosuppressed patient. We describe two patients with acute lymphoblastic leukaemia who attained complete remission, with partial or complete bone marrow recovery, but who went on to develop fatal invasive aspergillosis contemporaneous with recovery of neutrophil counts. Quantitative recovery of peripheral blood neutrophil counts does not guarantee control of Aspergillus infection, perhaps due to functional neutrophil deficiencies post-chemotherapy, and specific defensive strategies adopted by the organism itself.
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- Bodey G. P., Vartivarian S. Aspergillosis. Eur J Clin Microbiol Infect Dis. 1989 May;8(5):413–437. doi: 10.1007/BF01964057. [DOI] [PubMed] [Google Scholar]
- Cook D. J., Achong M. R., King D. E. Disseminated aspergillosis in an apparently healthy patient. Am J Med. 1990 Jan;88(1):74–76. doi: 10.1016/0002-9343(90)90132-w. [DOI] [PubMed] [Google Scholar]
- Denning D. W., Follansbee S. E., Scolaro M., Norris S., Edelstein H., Stevens D. A. Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med. 1991 Mar 7;324(10):654–662. doi: 10.1056/NEJM199103073241003. [DOI] [PubMed] [Google Scholar]
- Denning D. W., Stevens D. A. Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis. 1990 Nov-Dec;12(6):1147–1201. doi: 10.1093/clinids/12.6.1147. [DOI] [PubMed] [Google Scholar]
- Eisenstein D. J., Biddinger P. W., Rhodes J. C. Experimental murine invasive pulmonary aspergillosis. Am J Clin Pathol. 1990 Apr;93(4):510–515. doi: 10.1093/ajcp/93.4.510. [DOI] [PubMed] [Google Scholar]
- Klimowski L. L., Rotstein C., Cummings K. M. Incidence of nosocomial aspergillosis in patients with leukemia over a twenty-year period. Infect Control Hosp Epidemiol. 1989 Jul;10(7):299–305. doi: 10.1086/646032. [DOI] [PubMed] [Google Scholar]
- Robertson M. D., Kerr K. M., Seaton A. Killing of Aspergillus fumigatus spores by human lung macrophages: a paradoxical effect of heat-labile serum components. J Med Vet Mycol. 1989;27(5):295–302. doi: 10.1080/02681218980000401. [DOI] [PubMed] [Google Scholar]
- Robertson M. D., Seaton A., Raeburn J. A. Phagocytic cell responses to Aspergillus fumigatus. FEMS Microbiol Immunol. 1989 Apr;1(5):305–306. doi: 10.1111/j.1574-6968.1989.tb02401.x. [DOI] [PubMed] [Google Scholar]
- Spreadbury C. L., Krausz T., Pervez S., Cohen J. Invasive aspergillosis: clinical and pathological features of a new animal model. J Med Vet Mycol. 1989;27(1):5–15. doi: 10.1080/02681218980000021. [DOI] [PubMed] [Google Scholar]
- Stein D. K., Sugar A. M. Fungal infections in the immunocompromised host. Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4 Suppl):221S–228S. doi: 10.1016/0732-8893(89)90140-5. [DOI] [PubMed] [Google Scholar]
- Weiss S. J. Tissue destruction by neutrophils. N Engl J Med. 1989 Feb 9;320(6):365–376. doi: 10.1056/NEJM198902093200606. [DOI] [PubMed] [Google Scholar]
- Zimmerli W., Zarth A., Gratwohl A., Speck B. Neutrophil function and pyogenic infections in bone marrow transplant recipients. Blood. 1991 Jan 15;77(2):393–399. [PubMed] [Google Scholar]