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In the preparation of this address I have freely availed myself of the rich mine of material contained in the works of Tigerstedt (Die Physiologie des Kreislanges, 1893). Von Bezold (Die Innervation des Herzens. 1863), and the well-known textbooks of Foster and Schäfer. In particular I gratefully acknowledge much valuable help and counsel from my colleague, Dr. T. G. Brodie.