Skip to main content
NCBI home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1984 Jun;47(6):1355–1357. doi: 10.1128/aem.47.6.1355-1357.1984

Mutagenicity of tetramic mycotoxin cyclopiazonic acid.

W G Sorenson, J D Tucker, J P Simpson
PMCID: PMC240247  PMID: 6430233

Abstract

Cyclopiazonic acid was shown to be mutagenic to Salmonella typhimurium TA98 and TA100 in the presence of metabolic activation. The activity of cyclopiazonic acid in the presence of aflatoxin B1 was studied in complete factorial experiments with strain TA98. Both mycotoxins produced significant mutagenic activity and in combination. The activity in combination appeared to be additive rather than synergistic. The specific activity of cyclopiazonic acid was estimated to be approximately 140 revertants per mu mol in strain TA98.

Full text

PDF
1355

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames B. N., Mccann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res. 1975 Dec;31(6):347–364. doi: 10.1016/0165-1161(75)90046-1. [DOI] [PubMed] [Google Scholar]
  2. BUTLER W. H. ACUTE TOXICITY OF AFLATOXIN B-1 IN RATS. Br J Cancer. 1964 Dec;18:756–762. doi: 10.1038/bjc.1964.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gallagher R. T., Richard J. L., Stahr H. M., Cole R. J. Cyclopiazonic acid production by aflatoxigenic and non-aflatoxigenic strains of Aspergillus flavus. Mycopathologia. 1978 Dec 29;66(1-2):31–36. doi: 10.1007/BF00429590. [DOI] [PubMed] [Google Scholar]
  4. Holzapfel C. W. The isolation and structure of cyclopiazonic acid, a toxic metabolite of Penicillium cyclopium Westling. Tetrahedron. 1968 Mar;24(5):2101–2119. doi: 10.1016/0040-4020(68)88113-x. [DOI] [PubMed] [Google Scholar]
  5. Le Bars J. Cyclopiazonic acid production by Penicillium camemberti Thom and natural occurrence of this mycotoxin in cheese. Appl Environ Microbiol. 1979 Dec;38(6):1052–1055. doi: 10.1128/aem.38.6.1052-1055.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Luk K. C., Kobbe B., Townsend J. M. Production of cyclopiazonic acid by Aspergillus flavus Link. Appl Environ Microbiol. 1977 Jan;33(1):211–212. doi: 10.1128/aem.33.1.211-212.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ong T. M. Aflatoxin mutagenesis. Mutat Res. 1975;32(1):35–53. doi: 10.1016/0165-1110(75)90010-x. [DOI] [PubMed] [Google Scholar]
  8. Orth R. Mycotoxins of Aspergillus oryzae strains for use in the food industry as starters and enzyme producing molds. Ann Nutr Aliment. 1977;31(4-6):617–624. [PubMed] [Google Scholar]
  9. Purchase I. F. The acute toxicity of the mycotoxin cyclopiazonic acid to rats. Toxicol Appl Pharmacol. 1971 Jan;18(1):114–123. doi: 10.1016/0041-008x(71)90320-6. [DOI] [PubMed] [Google Scholar]
  10. Wehner F. C., Thiel P. G., van Rensburg S. J., Demasius I. P. Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins. Mutat Res. 1978 Nov;58(2-3):193–203. doi: 10.1016/0165-1218(78)90009-5. [DOI] [PubMed] [Google Scholar]
  11. Wogan G. N., Edwards G. S., Newberne P. M. Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs. Cancer Res. 1971 Dec;31(12):1936–1942. [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES