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. 1993 Apr;67(4):2367–2369. doi: 10.1128/jvi.67.4.2367-2369.1993

Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus.

O Ofori-Anyinam 1, R Vrijsen 1, P Kronenberger 1, A Boeyé 1
PMCID: PMC240400  PMID: 8383247

Abstract

R 78206 (a pyridazinamine derivative) inhibits the formation of poliovirus eclipse particles. Its effect on the intracellular location of poliovirus was studied by separating subcellular fractions in iso-osmotic Nycodenz gradients. The compound did not inhibit internalization of intact virus into small lipid vesicles, but it did inhibit the release of virus from these vesicles and its entry into lysosomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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