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. 1992 Dec;66(12):7549–7554. doi: 10.1128/jvi.66.12.7549-7554.1992

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.

L Zhang 1, P M Mohan 1, R Padmanabhan 1
PMCID: PMC240467  PMID: 1433530

Abstract

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

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Selected References

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