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. 1992 Dec;66(12):7572–7575. doi: 10.1128/jvi.66.12.7572-7575.1992

Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element.

H P Bogerd 1, L S Tiley 1, B R Cullen 1
PMCID: PMC240472  PMID: 1433531

Abstract

Expression of the structural proteins of human T-cell leukemia virus type I is dependent upon the interaction of the viral Rex trans activator with its highly structured cis-acting RNA target sequence, the 254-nucleotide Rex-response element. Nucleotides critical for Rex binding in vitro have been mapped by modification interference analysis to a discrete 12-nucleotide RNA sequence that is predicted to form a stem-bulge-stem structure. This minimal RNA binding site was sufficient to mediate specific Rex binding in vitro when analyzed in the context of a short RNA probe. The critical importance of this short RNA sequence in mediating Rex function in vivo is supported by its complete conservation among all primate T-cell leukemia virus isolates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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