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. 1991 Jan;65(1):457–460. doi: 10.1128/jvi.65.1.457-460.1991

Atypical dissemination of the highly neurotropic Borna disease virus during persistent infection in cyclosporine A-treated, immunosuppressed rats.

L Stitz 1, D Schilken 1, K Frese 1
PMCID: PMC240537  PMID: 1985209

Abstract

In adult rats infected with Borna disease virus, the virus was found exclusively in the brain, whereas in cyclosporine A-treated rats, infectious virus was also detected in peripheral nerve fibers and, unexpectedly, in adjacent organ-specific cells. In contrast to untreated virus-infected rats, no major histocompatibility complex class II expression was found in the brain of cyclosporine A-treated animals.

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Selected References

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