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. 1991 Jan;65(1):468–472. doi: 10.1128/jvi.65.1.468-472.1991

Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA.

G Sczakiel 1, M Pawlita 1
PMCID: PMC240540  PMID: 1985211

Abstract

Human T-lymphoid cell lines with constitutive intracellular expression of antisense RNA complementary to a 407-bp sequence of the 5' leader-gag region of human immunodeficiency virus type 1 were established by using a nonretroviral expression vector. In cell lines with antisense RNA expression detectable by Northern (RNA) hybridization, human immunodeficiency virus type 1 replication was inhibited to 88% 10 days postinfection and this inhibition lasted 3 weeks postinfection.

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Selected References

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