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. 1991 May;65(5):2237–2244. doi: 10.1128/jvi.65.5.2237-2244.1991

Pathways of activation of the Epstein-Barr virus productive cycle.

A J Sinclair 1, M Brimmell 1, F Shanahan 1, P J Farrell 1
PMCID: PMC240572  PMID: 1850009

Abstract

The promoter for the 2.8-kb RNA of Epstein-Barr virus encoding BZLF1 and BRLF1 was identified and shown to be activated by both BZLF1 and BRLF1 but not by 12-O-tetradecanoylphorbol-13-acetate. Site-directed mutagenesis suggests that two binding sites for BZLF1 within the promoter contribute to the transactivation by BZLF1. The early kinetics of induction of the 2.8- and 1.0-kb RNAs encoding BZLF1 and BRLF1 in Akata cells treated with anti-immunoglobulin indicate that both RNAs appear within 60 min. The results indicate some likely pathways of activation of Epstein-Barr virus productive cycle gene expression.

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Selected References

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