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. 1991 May;65(5):2707–2710. doi: 10.1128/jvi.65.5.2707-2710.1991

Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.

M Equestre 1, D Genovese 1, F Cavalieri 1, L Fiore 1, R Santoro 1, R Perez Bercoff 1
PMCID: PMC240633  PMID: 1850043

Abstract

Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.

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Selected References

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