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. 1992 Mar;66(3):1484–1488. doi: 10.1128/jvi.66.3.1484-1488.1992

Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.

G Hoffmann-Fezer 1, J Thum 1, C Ackley 1, M Herbold 1, J Mysliwietz 1, S Thefeld 1, K Hartmann 1, W Kraft 1
PMCID: PMC240873  PMID: 1310760

Abstract

T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4(+)-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seropositivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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