Table 3.
Named genes induced in 48-h TNF-α-treated chromaffin cells vs. control based on SSH analysis
| Gene | Ratio | Accession no. | Gene ID |
|---|---|---|---|
| Signal transduction | |||
| Nuclear factor of κ-light polypeptide gene enhancer in B-cells inhibitor, α | 2.47 ± 0.51 | NM_020529 | 4792 |
| Calcium modulating ligand | 1.83 ± 0.62 | NM_001745 | 819 |
| Mitogen-inducible gene 6 | 1.81 ± 0.38 | NM_018948 | 54206 |
| Stathmin-like 2 | 1.72 ± 0.26 | AK092187 | 11075 |
| Butyrate-induced transcript 1 | 1.52 ± 0.29 | BC058912 | 51495 |
| Transforming growth factor β receptor I | 1.51 ± 0.17 | BC071181 | 7046 |
| Intercellular signaling | |||
| Vasoactive intestinal polypeptide | 2.23 ± 0.28 | NM_173970 | 280956 |
| Proenkephalin | 1.88 ± 0.65 | NM_174141 | 281387 |
| Neuronal pentraxin | 1.69 ± 0.16 | NM_002522 | 4884 |
| Traffic/secretion | |||
| Secretogranin II (Chromogranin C) | 2.02 ± 0.75 | NM_174176 | 281477 |
| Sec61 γ subunit | 1.57 ± 0.28 | BC051840 | 23480 |
| Spastic paraplegia 3A (autosomal dominant) | 1.56 ± 0.21 | NM_181598 | 51062 |
| Metabolism | |||
| Similar to cytochrome P450 CYP3A24 | 2.40 ± 0.66 | XM_595414 | 517246 |
| Ubiquitin specific peptidase 12 | 1.65 ± 0.19 | AF022789 | 219333 |
| Phosphatidylinositol glycan, class S | 1.60 ± 0.15 | BC001319 | 94005 |
| Ferritin, heavy polypeptide 1 | 1.60 ± 0.41 | AF540563 | 281173 |
| Cellular adhesion/angiogenesis | |||
| Thrombospondin 1 | 1.69 ± 0.39 | NM_003246 | 7057 |
| Morphogenesis | |||
| Decorin | 1.61 ± 0.57 | NM_173906 | 280760 |
| Cell death | |||
| Tumor protein, translationally-controled 1 | 1.57 ± 0.24 | BC052333 | 7178 |
| Unknown function | |||
| VGF nerve growth factor inducible | 2.02 ± 0.37 | NM_003378 | 7425 |
| Selenoprotein K | 1.87 ± 0.22 | BC013162 | 58515 |
| Ribosomal protein L36a pseudogene | 1.59 ± 0.47 | NG_001571 | 207032 |
| LUC7-like 2 | 1.53 ± 0.23 | BC050708 | 51631 |
The GenBank accession no. and the Gene cluster (GeneID) for each gene are indicated. The ratios ± sem were determined from four different experiments.