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. 1992 Mar;66(3):1804–1808. doi: 10.1128/jvi.66.3.1804-1808.1992

Simian virus 40 (SV40) small t antigen inhibits SV40 DNA replication in vitro.

M Carbone 1, J Hauser 1, M P Carty 1, K Rundell 1, K Dixon 1, A S Levine 1
PMCID: PMC240946  PMID: 1310784

Abstract

We describe a biochemical function of simian virus 40 small t antigen, the inhibition of simian virus 40 large T antigen-mediated viral DNA replication in an in vitro replication system. Our results suggest that in this system, small t antigen prevents protein phosphatase 2A-mediated activation of large T antigen.

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Selected References

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