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. 1991 Jun;65(6):3349–3353. doi: 10.1128/jvi.65.6.3349-3353.1991

Transgenic thymocytes are refractory to transformation by the human T-cell leukemia virus type I tax gene.

M I Nerenberg 1, T Minor 1, J Price 1, D N Ernst 1, T Shinohara 1, H Schwarz 1
PMCID: PMC240995  PMID: 2033674

Abstract

Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.

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Selected References

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